Trial reportJournal of endocrinological investigation2016
Preoperative localization of an insulinoma: selective arterial calcium stimulation test performance.
Trial report in Journal of endocrinological investigation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Diagnostic value of ASVS for insulinoma localization: A systematic review and meta-analysis.PloS one · 2019Pooled it
- A Systematic Review of Proinsulin-Secreting Pancreatic Neuroendocrine Tumors.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2017Pooled it
- Minimally Invasive Resection of Occult Insulinomas-Experience from an ENETS Centre of Excellence and Review of the Literature.Cancers · 2025Article
- Case Report: A case of occult insulinoma localized by [Frontiers in endocrinology · 2025Article
- Approach to the Patient: Insulinoma.The Journal of clinical endocrinology and metabolism · 2024Article
- Single center experience in localization of insulinoma by selective intraarterial calcium stimulation angiography - a case series of 15 years.Frontiers in endocrinology · 2024Article
- Surgical Management of Pancreatic Neuroendocrine Tumors.Cancers · 2023Review
- Usefulness of selective arterial calcium injection tests for functional pancreatic neuroendocrine tumors.Scientific reports · 2021Article
- Low-dose Selective Arterial Calcium Stimulation Test for Localizing Insulinoma: A Single-center Experience of Five Consecutive Cases.Internal medicine (Tokyo, Japan) · 2020Article
- Essentials of Insulinoma Localization with Selective Arterial Calcium Stimulation and Hepatic Venous Sampling.Journal of clinical medicine · 2020Review
- Innovative imaging of insulinoma: the end of sampling? A review.Endocrine-related cancer · 2020Review
- Insulin autoimmune syndrome induced by exogenous insulin injection: a four-case series.BMC endocrine disorders · 2019Article
- Imaging of pancreatic neuroendocrine tumors: recent advances, current status, and controversies.Expert review of anticancer therapy · 2018Review
- Arterial stimulation with simultaneous venous sampling for localizing insulinomas.Journal of interventional medicine · 2018Article
- Non-surgical ablative therapies for inoperable benign insulinoma.Journal of endocrinological investigation · 2018Review
- Should the Selective Arterial Secretagogue Injection Test for Insulinoma Localization Be Evaluated at 60 or 120 Seconds?Internal medicine (Tokyo, Japan) · 2017Article
- Molecular imaging in neuroendocrine tumors: recent advances, controversies, unresolved issues, and roles in management.Current opinion in endocrinology, diabetes, and obesity · 2017Review
- Localization of Insulinoma Using 68Ga-DOTATATE PET/CT Scan.The Journal of clinical endocrinology and metabolism · 2017Article
- Insulinoma Due to Multiple Pancreatic Microadenoma Localized by Multimodal Imaging.The Journal of clinical endocrinology and metabolism · 2016Article
- Spontaneous hypoglycemia: diagnostic evaluation and management.Endocrine · 2016Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposePreoperative localization of an insulinoma is recommended to improve the cure rate, but non-invasive procedures can fail to detect the tumour. The objective of the study was to assess the performance of a selective arterial calcium stimulation test in the preoperative localization of insulinomas that were not detected by conventional imaging procedures.
methodsWe conducted a monocenter retrospective case review of 13 patients who had endogenous hyperinsulinism and were treated between 1994 and 2013. Patients were selected on the basis of negative or doubtful non-invasive preoperative imaging. A selective arterial calcium stimulation test was performed by pancreatic and hepatic arteriography with selective intra-arterial calcium stimulation and hepatic venous sampling in order to obtain the plasma insulin measurement. We evaluated the efficacy of the test by comparing the results with an endoscopic ultrasound.
resultsTwelve of the 13 patients underwent surgery, and the presence of an insulinoma was proven in 11 patients by pathological analysis of the tumour. An endoscopic ultrasound was consistent with surgery in 71.4 % of cases, while selective arterial calcium stimulation was consistent with surgery in 90.9 % and allowed detection of an insulinoma in two additional patients with a negative endoscopic ultrasound. One false-negative and one false-positive arterial calcium test were observed. No adverse events were recorded except transient skin flush following calcium injection in one patient.
conclusionThe selective arterial calcium stimulation test is a sensitive diagnostic procedure for localizing insulinomas and may be considered when non-invasive radiological imaging does not allow the detection of an occult insulinoma.
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