Evidence map›Paper›PMID 26576862›Full record

SynthesisScientific reports2015

Effectiveness and safety of Glucosamine, chondroitin, the two in combination, or celecoxib in the treatment of osteoarthritis of the knee.

Chao Zeng, Jie Wei, Hui Li, Yi-lun Wang, Dong-xing Xie, Tuo Yang, Shu-guang Gao, Yu-sheng Li, Wei Luo, Guang-hua Lei

Open access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 9 pooled it
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 9 syntheses or guidelines pooled it, 69 citations in OpenAlex.

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  6. Guideline
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  16. Geroprotectors and Skeletal Health: Beyond the Headlines.Frontiers in cell and developmental biology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Chao ZengDepartment of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan Province, China, 410008.
Jie WeiHealth Management Center, Xiangya Hospital, Central South University, Changsha, Hunan Province, China, 410008.
Hui LiDepartment of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan Province, China, 410008.
Yi-lun WangDepartment of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan Province, China, 410008.
Dong-xing XieDepartment of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan Province, China, 410008.
Tuo YangDepartment of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan Province, China, 410008.
Shu-guang GaoDepartment of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan Province, China, 410008.
Yu-sheng LiDepartment of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan Province, China, 410008.
Wei LuoDepartment of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan Province, China, 410008.
Guang-hua LeiDepartment of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan Province, China, 410008.
Central South University · CNXiangya Hospital Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to investigate the effectiveness and safety of glucosamine, chondroitin, the two in combination, or celecoxib in the treatment of knee osteoarthritis (OA). PubMed, Embase and Cochrane Library were searched through from inception to February 2015. A total of 54 studies covering 16427 patients were included. Glucosamine plus chondroitin, glucosamine alone, and celecoxib were all more effective than placebo in pain relief and function improvement. Specifically, celecoxib is most likely to be the best treatment option, followed by the combination group. All treatment options showed clinically significant improvement from baseline pain, but only glucosamine plus chondroitin showed clinically significant improvement from baseline function. In terms of the structure-modifying effect, both glucosamine alone and chondroitin alone achieved a statistically significant reduction in joint space narrowing. Although no significant difference was observed among the five options with respect to the three major adverse effects (withdrawal due to adverse events, serious adverse events and the number of patients with adverse events), the additional classical meta-analysis showed that celecoxib exhibited a higher rate of gastrointestinal adverse effect comparing with the placebo group. The present study provided evidence for the symptomatic efficacy of glucosamine plus chondroitin in the treatment of knee OA.

Indexed as

ArthralgiaCelecoxibChondroitinDrug Therapy, CombinationGlucosamineHumansOdds RatioOsteoarthritis, KneePain ManagementTreatment OutcomeCelecoxibChondroitinGlucosamine

Identifiers

PMID26576862
PMCPMC4649492
OpenAlexW2219147137

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.