ArticleMolecular biology and evolution2016
Genomic Characterization of a South American Phytophthora Hybrid Mandates Reassessment of the Geographic Origins of Phytophthora infestans.
Article in Molecular biology and evolution, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Oomycete plant pathogens: biology, pathogenesis and emerging control strategies.Nature reviews. Microbiology · 2026Review
- Developing a crop- wild-reservoir pathogen system to understand pathogen evolution and emergence.eLife · 2025Article
- A pangenome analysis reveals the center of origin and evolutionary history of Phytophthora infestans and 1c clade species.PloS one · 2025Article
- Evolution of Phytophthora infestans on its potato host since the Irish potato famine.Nature communications · 2024Article
- Reconstructing historic and modern potato late blight outbreaks using text analytics.Scientific reports · 2024Article
- Plant NLR immunity activation and execution: a biochemical perspective.Open biology · 2024Review
- Comparative Analyses of Complete Peronosporaceae (Oomycota) Mitogenome Sequences-Insights into Structural Evolution and Phylogeny.Genome biology and evolution · 2022Article
- Global historic pandemics caused by the FAM-1 genotype of Phytophthora infestans on six continents.Scientific reports · 2021Article
- The persistent threat of emerging plant disease pandemics to global food security.Proceedings of the National Academy of Sciences of the United States of America · 2021Review
- Population Structure of Phytophthora infestans from a Single Location in Poland Over a Long Period of Time in Context of Weather Conditions.Microbial ecology · 2021Article
- The mitogenome of Phytophthora agathidicida: Evidence for a not so recent arrival of the "kauri killing" Phytophthora in New Zealand.PloS one · 2021Article
- Variola virus genome sequenced from an eighteenth-century museum specimen supports the recent origin of smallpox.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- The Recovery, Interpretation and Use of Ancient Pathogen Genomes.Current biology : CB · 2020Review
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- Pathogen enrichment sequencing (PenSeq) enables population genomic studies in oomycetes.The New phytologist · 2019Article
- Insights into evolving global populations of Phytophthora infestans via new complementary mtDNA haplotype markers and nuclear SSRs.PloS one · 2019Article
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- Large sub-clonal variation in Phytophthora infestans from recent severe late blight epidemics in India.Scientific reports · 2018Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As the oomycete pathogen causing potato late blight disease, Phytophthora infestans triggered the famous 19th-century Irish potato famine and remains the leading cause of global commercial potato crop destruction. But the geographic origin of the genotype that caused this devastating initial outbreak remains disputed, as does the New World center of origin of the species itself. Both Mexico and South America have been proposed, generating considerable controversy. Here, we readdress the pathogen's origins using a genomic data set encompassing 71 globally sourced modern and historical samples of P. infestans and the hybrid species P. andina, a close relative known only from the Andean highlands. Previous studies have suggested that the nuclear DNA lineage behind the initial outbreaks in Europe in 1845 is now extinct. Analysis of P. andina's phased haplotypes recovered eight haploid genome sequences, four of which represent a previously unknown basal lineage of P. infestans closely related to the famine-era lineage. Our analyses further reveal that clonal lineages of both P. andina and historical P. infestans diverged earlier than modern Mexican lineages, casting doubt on recent claims of a Mexican center of origin. Finally, we use haplotype phasing to demonstrate that basal branches of the clade comprising Mexican samples are occupied by clonal isolates collected from wild Solanum hosts, suggesting that modern Mexican P. infestans diversified on Solanum tuberosum after a host jump from a wild species and that the origins of P. infestans are more complex than was previously thought.
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