ArticleScientific reports2015
Inner retinal oxygen metabolism in the 50/10 oxygen-induced retinopathy model.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 3 of them syntheses that pooled it.
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Who cites it
39 citing papers in PubMed, 3 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Noninvasive hemoglobin sensing and imaging: optical tools for disease diagnosis.Journal of biomedical optics · 2022Pooled it
- Chorioamnionitis as a risk factor for retinopathy of prematurity: An updated systematic review and meta-analysis.PloS one · 2018Pooled it
- Probiotic supplementation in preterm infants does not affect the risk of retinopathy of prematurity: a meta-analysis of randomized controlled trials.Scientific reports · 2017Pooled it
- Beyond Neovascularization: Light Response Deficits in Oxygen-Induced Retinopathy Models.Investigative ophthalmology & visual science · 2026Review
- Insights on Acute and Chronic Lacquer Cracks as Imaged with Visible Light OCT.Ophthalmology science · 2026Article
- Blood flow analysis of retinal neovascularisations in a VLDLR mouse model using contrast-enhanced optical coherence tomography.Biomedical optics express · 2026Article
- A direct method for imaging gradient levels of retinal hypoxia in a model of retinopathy of prematurity (ROP).BMC ophthalmology · 2026Article
- Imaging of the retinal hypoxia: A journey from oxygen microelectrode to the first hypoxia imaging in the living retina.Progress in retinal and eye research · 2025Review
- Assessing and monitoring abnormal retinal blood circulation for early detection of pre-structural damage and enhanced diabetic retinopathy staging using non-invasive, high-resolution biophotonic imaging technology.Eye (London, England) · 2025Review
- Targeting ATF6 reduces pathological neovascularization and improves visual outcomes in retinal disease models.Scientific reports · 2025Article
- Visible Light Optical Coherence Tomography: Technology and Biomedical Applications.Bioengineering (Basel, Switzerland) · 2025Review
- Visible-light optical coherence tomography and its applications.Neurophotonics · 2025Review
- A Dual-Camera High-Resolution Hyperspectral Imaging System for the Retina.Proceedings of SPIE--the International Society for Optical Engineering · 2025Article
- Imaging Hypoxia to Predict Primary Neuronal Cell Damage in Branch Retinal Artery Occlusion.Microcirculation (New York, N.Y. : 1994) · 2024Article
- Adaptive spectroscopic visible-light optical coherence tomography for clinical retinal oximetry.Communications medicine · 2023Article
- The Development and Clinical Application of Innovative Optical Ophthalmic Imaging Techniques.Frontiers in medicine · 2022Review
- Mingmu Xiaoyao granules regulate the PI3K/Akt/mTOR signaling pathway to reduce anxiety and depression and reverse retinal abnormalities in rats.Frontiers in pharmacology · 2022Article
- An imbalance in autophagy contributes to retinal damage in a rat model of oxygen-induced retinopathy.Journal of cellular and molecular medicine · 2021Article
- Longitudinal deep-brain imaging in mouse using visible-light optical coherence tomography through chronic microprism cranial window.Biomedical optics express · 2019Article
- Designing visible-light optical coherence tomography towards clinics.Quantitative imaging in medicine and surgery · 2019Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Retinopathy of prematurity (ROP) represents a major cause of childhood vision loss worldwide. The 50/10 oxygen-induced retinopathy (OIR) model mimics the findings of ROP, including peripheral vascular attenuation and neovascularization. The oxygen metabolism of the inner retina has not been previously explored in this model. Using visible-light optical coherence tomography (vis-OCT), we measured the oxygen saturation of hemoglobin and blood flow within inner retinal vessels, enabling us to compute the inner retinal oxygen delivery (irDO2) and metabolic rate of oxygen (irMRO2). We compared these measurements between age-matched room-air controls and rats with 50/10 OIR on postnatal day 18. To account for a 61% decrease in the irDO2 in the OIR group, we found an overall statistically significant decrease in retinal vascular density affecting the superficial and deep retinal vascular capillary networks in rats with OIR compared to controls. Furthermore, matching the reduced irDO2, we found a 59% decrease in irMRO2, which we correlated with a statistically significant reduction in retinal thickness in the OIR group, suggesting that the decreased irMRO2 was due to decreased neuronal oxygen utilization. By exploring these biological and metabolic changes in great detail, our study provides an improved understanding of the pathophysiology of OIR model.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.