Evidence map›Paper›PMID 26576546›Full record

Observational studyNeurogenetics2016

COMT Val 158 Met polymorphism is associated with nonverbal cognition following mild traumatic brain injury.

Ethan A Winkler, John K Yue, Thomas W McAllister, Nancy R Temkin, Sam S Oh, Esteban G Burchard, Donglei Hu, Adam R Ferguson, Hester F Lingsma, John F Burke and 17 more

Registry-linked trialOpen access · greenAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Neurogenetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01565551 (Transforming Research and Clinical Knowledge in Traumatic Brain Injury Pilot), which is not on this map. Cited by 24 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 2 pooled it
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01565551 completednot on this map

Transforming Research and Clinical Knowledge in Traumatic Brain Injury Pilot

TypeobservationalSponsorUniversity of California, San FranciscoRan2010 to 2013Enrolled650ConditionsTraumatic Brain InjuryArmsN/A (Observational Study)
3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. DownstreamJournal of neurotrauma · 2019
    Article
  11. Review
  12. Review
  13. Review
  14. Review
  15. Regionally clusteredJournal of neurology, neurosurgery, and psychiatry · 2018
    Article
  16. Placebo Effects in Traumatic Brain Injury.Journal of neurotrauma · 2018
    Review
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 7 institutions in 2 countries.

Ethan A WinklerDepartment of Neurological Surgery, University of California, San Francisco, 1001 Potrero Avenue, Building 1, Room 101, San Francisco, CA, 94110, USA.
John K YueDepartment of Neurological Surgery, University of California, San Francisco, 1001 Potrero Avenue, Building 1, Room 101, San Francisco, CA, 94110, USA.
Thomas W McAllisterDepartment of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA.
Nancy R TemkinDepartments of Neurological Surgery and Biostatistics, University of Washington, Seattle, WA, USA.
Sam S OhDepartment of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, USA.
Esteban G BurchardDepartment of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, USA.
Donglei HuDepartment of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, USA.
Adam R FergusonDepartment of Neurological Surgery, University of California, San Francisco, 1001 Potrero Avenue, Building 1, Room 101, San Francisco, CA, 94110, USA.
Hester F LingsmaDepartment of Public Health, Erasmus Medical Center, Rotterdam, The Netherlands.
John F BurkeDepartment of Neurological Surgery, University of California, San Francisco, 1001 Potrero Avenue, Building 1, Room 101, San Francisco, CA, 94110, USA.
Marco D SoraniDepartment of Neurological Surgery, University of California, San Francisco, 1001 Potrero Avenue, Building 1, Room 101, San Francisco, CA, 94110, USA.
Jonathan RosandDepartment of Neurology, Harvard Medical School, Boston, MA, USA.
Esther L YuhBrain and Spinal Injury Center, San Francisco General Hospital, San Francisco, CA, USA.
Jason BarberDepartments of Neurological Surgery and Biostatistics, University of Washington, Seattle, WA, USA.
Phiroz E TaraporeDepartment of Neurological Surgery, University of California, San Francisco, 1001 Potrero Avenue, Building 1, Room 101, San Francisco, CA, 94110, USA.
Raquel C GardnerDepartment of Neurology, Harvard Medical School, Boston, MA, USA.
Sourabh SharmaDepartment of Neurological Surgery, University of California, San Francisco, 1001 Potrero Avenue, Building 1, Room 101, San Francisco, CA, 94110, USA.
Gabriela G SatrisDepartment of Neurological Surgery, University of California, San Francisco, 1001 Potrero Avenue, Building 1, Room 101, San Francisco, CA, 94110, USA.
Celeste EngDepartment of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, USA.
Ava M PuccioDepartment of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Kevin K W WangCenter for Neuroproteomics and Biomarkers Research, Departments of Psychiatry and Neuroscience, University of Florida, Gainesville, FL, USA.
Pratik MukherjeeBrain and Spinal Injury Center, San Francisco General Hospital, San Francisco, CA, USA.
Alex B ValadkaSeton Brain and Spine Institute, Austin, TX, USA.
David O OkonkwoDepartment of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Ramon Diaz-ArrastiaDepartment of Neurology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Geoffrey T ManleyDepartment of Neurological Surgery, University of California, San Francisco, 1001 Potrero Avenue, Building 1, Room 101, San Francisco, CA, 94110, USA. manleyg@neurosurg.ucsf.edu.
TRACK-TBI Investigators
San Francisco General Hospital · USUniversity of California, San Francisco · USBroad Institute · USUniformed Services University of the Health Sciences · USUniversity of Florida · USUniversity of Pittsburgh Medical Center · USUniversity of Washington · US

Funding

VARC CoreP30AG044281 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Alexander Keliimoeanu Smith · 2013 to 2026
$19.9M
Transforming Research and Clinical Knowledge in Traumatic Brain InjuryU01NS086090 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DIAZ-ARRASTIA, RAMON, GIACINO, JOSEPH THOMAS · 2013 to 2017
$19.1M
Transforming Traumatic Brain Injury Research and Clinical CareRC2NS069409 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MANLEY, GEOFFREY T · 2009 to 2011
$4.3M
Traumatic Brain Injury and The Aging Brain: Predictors of Clinical TrajectoriesK23NS095755 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GARDNER, RAQUEL C. · 2015 to 2019
$872k
NIA NIH HHS P30 AG044281NINDS NIH HHS K23 NS095755NINDS NIH HHS RC2 NS069409NINDS NIH HHS RC2NS069409NINDS NIH HHS RC2 NS069409-02S1NINDS NIH HHS U01 NS086090NINDS NIH HHS U01 NS086090-01
6 · The paper itself

Abstract

Mild traumatic brain injury (mTBI) results in variable clinical outcomes, which may be influenced by genetic variation. A single-nucleotide polymorphism in catechol-o-methyltransferase (COMT), an enzyme which degrades catecholamine neurotransmitters, may influence cognitive deficits following moderate and/or severe head trauma. However, this has been disputed, and its role in mTBI has not been studied. Here, we utilize the Transforming Research and Clinical Knowledge in Traumatic Brain Injury Pilot (TRACK-TBI Pilot) study to investigate whether the COMT Val (158) Met polymorphism influences outcome on a cognitive battery 6 months following mTBI--Wechsler Adult Intelligence Test Processing Speed Index Composite Score (WAIS-PSI), Trail Making Test (TMT) Trail B minus Trail A time, and California Verbal Learning Test, Second Edition Trial 1-5 Standard Score (CVLT-II). All patients had an emergency department Glasgow Coma Scale (GCS) of 13-15, no acute intracranial pathology on head CT, and no polytrauma as defined by an Abbreviated Injury Scale (AIS) score of ≥3 in any extracranial region. Results in 100 subjects aged 40.9 (SD 15.2) years (COMT Met (158) /Met (158) 29 %, Met (158) /Val (158) 47 %, Val (158) /Val (158) 24 %) show that the COMT Met (158) allele (mean 101.6 ± SE 2.1) associates with higher nonverbal processing speed on the WAIS-PSI when compared to Val (158) /Val (158) homozygotes (93.8 ± SE 3.0) after controlling for demographics and injury severity (mean increase 7.9 points, 95 % CI [1.4 to 14.3], p = 0.017). The COMT Val (158) Met polymorphism did not associate with mental flexibility on the TMT or with verbal learning on the CVLT-II. Hence, COMT Val (158) Met may preferentially modulate nonverbal cognition following uncomplicated mTBI.Registry: ClinicalTrials.gov Identifier NCT01565551.

Indexed as

Amino Acid SubstitutionCognitionPolymorphism, Single NucleotideAdultBrain InjuriesCatechol O-MethyltransferaseCognition DisordersFemaleGenetic Association StudiesHumansMaleMethionineMiddle AgedMutation, MissenseNeuropsychological TestsPilot ProjectsCatechol O-MethyltransferaseCOMT protein, humanMethionineValineCognitive functionGenetic factorsHuman studiesOutcome measuresTraumatic brain injury

Identifiers

PMID26576546
PMCPMC4988810
OpenAlexW2275287493

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.