ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2016
Antiresorptive therapy and risk of mortality and refracture in osteoporosis-related hip fracture: a nationwide study.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.
- Cardiovascular Safety and Effectiveness of Bisphosphonates: From Intervention Trials to Real-Life Data.Nutrients · 2022Pooled it
- The recurrence of osteoporotic fractures among first- and second-generation immigrants in Sweden.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Article
- Article
- Osteoporosis management in patients presenting to the emergency department with fragility fractures: A retrospective observational study.Journal of diabetes and metabolic disorders · 2025Article
- Developing a prediction model for preoperative acute heart failure in elderly hip fracture patients: a retrospective analysis.BMC musculoskeletal disorders · 2024Article
- Mortality and re-fracture rates in low trauma hip fracture.BMC geriatrics · 2024Article
- The Efficiency of Antiosteoporosis Medicine after Intertrochanteric Fracture Surgery: A Retrospective Study of Refracture Rate, Function Recovery, Complications, and Mortality in the Chinese Elderly Population.Surgery journal (New York, N.Y.) · 2024Article
- Age-dependent gender differences in the diagnosis and treatment of osteoporosis during hospitalization in patients with fragility fractures.BMC geriatrics · 2023Article
- Hip fracture incidence and post-fracture mortality in Victoria, Australia: a state-wide cohort study.Archives of osteoporosis · 2023Article
- [Osteoporosis: diagnostics and treatment].Orthopadie (Heidelberg, Germany) · 2023Article
- Exploring the osteoporosis treatment gap after fragility hip fracture at a Tertiary University Medical Center in Thailand.BMC geriatrics · 2023Article
- [Osteoporosis: diagnostics and treatment].Zeitschrift fur Gerontologie und Geriatrie · 2022Article
- Risk factors of primary and recurrent fractures in postmenopausal osteoporotic Chinese patients: A retrospective analysis study.BMC women's health · 2022Article
- [Osteoporosis: diagnostics and treatment].Chirurgie (Heidelberg, Germany) · 2022Article
- A 2-year follow-up of a novel Fracture Liaison Service: can we reduce the mortality in elderly hip fracture patients? A prospective cohort study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2022Article
- Patient-specific risk factors for adverse outcomes following geriatric proximal femur fractures.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2022Review
- Real-World Effectiveness of Anti-Resorptive Treatment in Patients With Incident Fragility Fractures-The STORM Cohort-A Swedish Retrospective Observational Study.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022Observational
- Incidence of different types of subsequent fractures and related mortality in Taiwan.Archives of osteoporosis · 2022Article
- One- and 2-year incidence of osteoporotic fracture: a multi-cohort observational study using routinely collected real-world data.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2022Observational
- All-cause mortality risk in aged femoral intertrochanteric fracture patients.Journal of orthopaedic surgery and research · 2021Article
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledWe analyzed the association of bisphosphonate therapy with mortality and hip refracture incidence among osteoporosis-related hip fracture patients in Austria. Mortality was lower in primarily female bisphosphonate users, while hip refracture incidence was generally elevated relative to controls, indicating beneficial effects of bisphosphonates other than on bone.
introductionThe purpose of this study was to analyze mortality and hip refracture risk in osteoporotic hip fracture patients with and without antiosteoporotic medication.
methodsWe retrospectively analyzed data on 31,668 Austrian patients ≥50 years with a hip fracture between July 2008 and December 2010 for antiosteoporotic drug treatment with respect to outcome parameters all-cause mortality, hip refracture incidence, and hip refracture-free days. Outcomes when bisphosphonate (BP) treatment was begun before or after fracture were compared with an age- and sex-matched hip fracture control without antiosteoporotic medication.
results27.69 % of patients (33.01 % of women, 13.13 % of men) were prescribed antiosteoporotic medication, primarily BPs. Females having initiated BP treatment before first fracture had lower odds for mortality 1 and 3 year(s) post-fracture, whereas hip refracture incidence under pre-fracture BP initiation was generally higher. Treatment that was started after fracture, however, entailed significantly lower mortality hazards for both genders (HR 0.43, 95 %CI 0.36-0.52, p < 0.0001 after 1 year) but significantly higher hip refracture incidence except for patients aged 50-69 years and more hip refracture free days for females. Hip refractures overall amounted to 29.22/1000 patient years differing significantly between women and men (31.03 vs. 23.89, respectively, p < 0.0001), and longer hip refracture free survival was observed for women than for men (499 vs. 466 median days, respectively, p < 0.0001).
conclusionsAlthough BP use is associated with reduced mortality after hip fracture, notably among women, hip refracture incidences are likewise elevated, which is most likely accounted for by a high probability of BP prescription to more comorbid patients suffering from more severe osteoporosis. Concomitantly, through possible effects other than on bone, BPs might be able to curtail mortality. Male hip fracture patients' low treatment frequency in particular reflects underdiagnosis and undertreatment of osteoporosis in Austria.
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