ArticleJournal of cellular and molecular medicine2016
Restoring the youth of aged red blood cells and extending their lifespan in circulation by remodelling membrane sialic acid.
Article in Journal of cellular and molecular medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 52 citations in OpenAlex.
- Automated method for determining the zeta potential of red blood cells via motion tracking in microelectrophoresis.Biochemistry and biophysics reports · 2026Article
- Main events and mechanism of human erythrocyte ageing.Expert reviews in molecular medicine · 2026Review
- Recover aged/damaged erythrocytes and prevent them from aging by remodeling or enhancing their vital proteins: Hb and B3p.Frontiers in cell and developmental biology · 2026Article
- One trigger, two fates: hemolysate shapes neutrophil extracellular traps (NETs) formation in a context-dependent manner.Frontiers in immunology · 2026Article
- Redefining the concept of erythrocyte senescence: is eryptosis fundamentally different from erythrocyte senescence.GeroScience · 2025Review
- Chitosan-Nanomaterials (Basel, Switzerland) · 2025Article
- Chrysin, a glycolytic inhibitor, modulates redox homeostasis during aging via a potent calorie restriction mimetic effect in male wistar rats.Biogerontology · 2025Article
- Cellular determinants influence the red blood cell adsorption efficiency of poly(amine-Science advances · 2025Article
- Relationship between dietary sialic acid intake and serum HbA1c: a population-based study in Xiamen, China.Scientific reports · 2024Article
- Sialic acid in the regulation of blood cell production, differentiation and turnover.Immunology · 2024Review
- Review
- A new role for erythropoietin in the homeostasis of red blood cells.Communications biology · 2024Article
- Curcumin displays a potent caloric restriction mimetic effect in an accelerated senescent model of rat.Biologia futura · 2023Article
- Cell Membrane Biomimetic Nanoparticles with Potential in Treatment of Alzheimer's Disease.Molecules (Basel, Switzerland) · 2023Review
- Modularity of RBC hitchhiking with polymeric nanoparticles: testing the limits of non-covalent adsorption.Journal of nanobiotechnology · 2022Article
- Cell membrane camouflaged biomimetic nanoparticles: Focusing on tumor theranostics.Materials today. Bio · 2022Article
- Oxidative stress activates red cell adhesion to laminin in sickle cell disease.Haematologica · 2021Article
- Red Blood Cell Membrane Bioengineered Zr-89 Labelled Hollow Mesoporous Silica Nanosphere for Overcoming Phagocytosis.Scientific reports · 2019Article
- Glycophorin-C sialylation regulates Lu/BCAM adhesive capacity during erythrocyte aging.Blood advances · 2018Article
- ABO blood groups and galectins: Implications in transfusion medicine and innate immunity.Seminars in immunologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Membrane sialic acid (SA) plays an important role in the survival of red blood cells (RBCs), the age-related reduction in SA content negatively impacts both the structure and function of these cells. We have therefore suggested that remodelling the SA in the membrane of aged cells would help recover cellular functions characteristic of young RBCs. We developed an effective method for the re-sialylation of aged RBCs by which the cells were incubated with SA in the presence of cytidine triphosphate (CTP) and α-2,3-sialytransferase. We found that RBCs could be re-sialylated if they had available SA-binding groups and after the re-sialylation, aged RBCs could restore their membrane SA to the level in young RBCs. Once the membrane SA was restored, the aged RBCs showed recovery of their biophysical and biochemical properties to similar levels as in young RBCs. Their life span in circulation was also extended to twofold. Our findings indicate that remodelling membrane SA not only helps restore the youth of aged RBCs, but also helps recover injured RBCs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.