ArticleScientific reports2015
Structural insights into HetR-PatS interaction involved in cyanobacterial pattern formation.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Coordination of NProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Co-option of an ancestral peptidase controls developmental patterning in multicellular cyanobacteria.iScience · 2026Article
- PatU3 plays a central role in coordinating cell division and differentiation in pattern formation of filamentous cyanobacterium Nostoc sp. PCC 7120.Science China. Life sciences · 2023Article
- Terminal heterocyst differentiation in the Anabaena patA mutant as a result of post-transcriptional modifications and molecular leakage.PLoS computational biology · 2022Article
- Interaction network among factors involved in heterocyst-patterning in cyanobacteria.Molecular genetics and genomics : MGG · 2022Article
- Mathematical models of nitrogen-fixing cell patterns in filamentous cyanobacteria.Frontiers in cell and developmental biology · 2022Review
- Heterocyst Development and Diazotrophic Growth ofLife (Basel, Switzerland) · 2020Article
- HetL, HetR and PatS form a reaction-diffusion system to control pattern formation in the cyanobacteriumeLife · 2020Article
- Expression from DIF1-motif promoters of hetR and patS is dependent on HetZ and modulated by PatU3 during heterocyst differentiation.PloS one · 2020Article
- Article
- Preventing Accidental Heterocyst Development in Cyanobacteria.Journal of bacteriology · 2019Article
- The Pkn22 Kinase ofFrontiers in microbiology · 2019Article
- Manipulation of Pattern of Cell Differentiation in aLife (Basel, Switzerland) · 2018Article
- The Ser/Thr Kinase PknH Is Essential for Maintaining Heterocyst Pattern in the CyanobacteriumLife (Basel, Switzerland) · 2018Article
- Role of PatS and cell type on the heterocyst spacing pattern in a filamentous branching cyanobacterium.FEMS microbiology letters · 2017Article
- Formation and maintenance of nitrogen-fixing cell patterns in filamentous cyanobacteria.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
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19 authors.
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Abstract
The one-dimensional pattern of heterocyst in the model cyanobacterium Anabaena sp. PCC 7120 is coordinated by the transcription factor HetR and PatS peptide. Here we report the complex structures of HetR binding to DNA, and its hood domain (HetRHood) binding to a PatS-derived hexapeptide (PatS6) at 2.80 and 2.10 Å, respectively. The intertwined HetR dimer possesses a couple of novel HTH motifs, each of which consists of two canonical α-helices in the DNA-binding domain and an auxiliary α-helix from the flap domain of the neighboring subunit. Two PatS6 peptides bind to the lateral clefts of HetRHood, and trigger significant conformational changes of the flap domain, resulting in dissociation of the auxiliary α-helix and eventually release of HetR from the DNA major grove. These findings provide the structural insights into a prokaryotic example of Turing model.
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