Evidence map›Paper›PMID 26576323›Full record

ArticleACS catalysis2015

Activation of Two Sequential H-transfers in the Thymidylate Synthase Catalyzed Reaction.

Zahidul Islam, Timothy S Strutzenberg, Ananda K Ghosh, Amnon Kohen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS catalysis, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Noncovalent Intermediate of Thymidylate Synthase: Fact or Fiction?Journal of the American Chemical Society · 2016
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Zahidul IslamThe Department of Chemistry, The University of Iowa, Iowa City, IA 52242, U.S.A.
Timothy S StrutzenbergThe Department of Chemistry, The University of Iowa, Iowa City, IA 52242, U.S.A.
Ananda K GhoshThe Department of Chemistry, The University of Iowa, Iowa City, IA 52242, U.S.A.
Amnon KohenThe Department of Chemistry, The University of Iowa, Iowa City, IA 52242, U.S.A.
University of Iowa · US

Funding

PREDOCTORAL TRAINING PROGRAM IN BIOTECHNOLOGYT32GM008365 · NIGMS · UNIVERSITY OF IOWA · PI KERNS, ROBERT JOHN · 1990 to 2021
$3.8M
Tunneling and dynamic studies with DHFRR01GM065368 · NIGMS · UNIVERSITY OF IOWA · PI CHEATUM, CHRISTOPHER M · 2002 to 2017
$3.5M
NIGMS NIH HHS R01 GM065368NIGMS NIH HHS T32 GM008365
6 · The paper itself

Abstract

Thymidylate synthase (TSase) catalyzes the

Indexed as

C-H bond activationDonor and acceptor distancesKinetic Isotope EffectPhenomenological modelsQM/MM calculationsThymidylate SynthaseTunneling ready state

Identifiers

PMID26576323
PMCPMC4643671
OpenAlexW2437715850

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.