Evidence map›Paper›PMID 26576276›Full record

ArticleClinical case reports2015

Can stapedius reflex testing objectively measure muscle function in Pompe patients?

Max J Hilz, Ulrich Hoppe, Sebastian Moeller, Ruihao Wang, Julia Koehn

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical case reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 91% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Max J HilzDepartment of Neurology, University of Erlangen-Nuremberg Schwabachanlage 6, D-91054, Erlangen, Germany.
Ulrich HoppeDepartment of Audiology, University of Erlangen-Nuremberg Waldstraße 1, D-91054, Erlangen, Germany.
Sebastian MoellerDepartment of Neurology, University of Erlangen-Nuremberg Schwabachanlage 6, D-91054, Erlangen, Germany.
Ruihao WangDepartment of Neurology, University of Erlangen-Nuremberg Schwabachanlage 6, D-91054, Erlangen, Germany.
Julia KoehnDepartment of Neurology, University of Erlangen-Nuremberg Schwabachanlage 6, D-91054, Erlangen, Germany.
Friedrich-Alexander-Universität Erlangen-Nürnberg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We assessed the value of stapedius reflex testing as an objective measurement of striated muscle function in four patients with Pompe disease. Common tests of disease severity and efficacy of enzyme replacement therapy (ERT) yield highly variable results that depend on patient cooperation and day-to-day performance, whereas stapedius reflex thresholds improved in seven of eight ears after 2 years of ERT.

Indexed as

Enzyme replacement therapymuscle functionPompe diseasestapedius reflex testing

Identifiers

PMID26576276
PMCPMC4641478
OpenAlexW2164238215

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.