Evidence map›Paper›PMID 26576228›Full record

ArticleOxidative medicine and cellular longevity2015

Insulin Therapy of Nondiabetic Septic Patients Is Predicted by para-Tyrosine/Phenylalanine Ratio and by Hydroxyl Radical-Derived Products of Phenylalanine.

Szilárd Kun, Gergő A Molnár, Eszter Sélley, Lívia Szélig, Lajos Bogár, Csaba Csontos, Attila Miseta, István Wittmann

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oxidative medicine and cellular longevity, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03278730 (Phase 2 Single Center, Randomized, Placebo-controlled, Double-blind, Parallel Group Study to Evaluate Efficacy of Para-Tyrosine Supplementation on the Survival and Clinical Outcome in Patients With Sepsis), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03278730 phase2suspendednot on this mapstarted 2027, after this paper: background citation

Phase 2 Single Center, Randomized, Placebo-controlled, Double-blind, Parallel Group Study to Evaluate Efficacy of Para-Tyrosine Supplementation on the Survival and Clinical Outcome in Patients With Sepsis

TypeinterventionalSponsorUniversity of PecsRan2027 to 2027Enrolled296ConditionsSepsisArmsPara-Tyrosine supplementation, Placebo solution
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Szilárd Kun2nd Department of Medicine and Nephrological Centre, Faculty of Medicine, University of Pécs, Pacsirta Street 1, Pécs 7624, Hungary.
Gergő A Molnár2nd Department of Medicine and Nephrological Centre, Faculty of Medicine, University of Pécs, Pacsirta Street 1, Pécs 7624, Hungary.
Eszter Sélley2nd Department of Medicine and Nephrological Centre, Faculty of Medicine, University of Pécs, Pacsirta Street 1, Pécs 7624, Hungary.
Lívia SzéligDepartment of Anaesthesia and Intensive Care, Faculty of Medicine, University of Pécs, Rákóczi Street 2, Pécs 7623, Hungary.
Lajos BogárDepartment of Anaesthesia and Intensive Care, Faculty of Medicine, University of Pécs, Rákóczi Street 2, Pécs 7623, Hungary.
Csaba CsontosDepartment of Anaesthesia and Intensive Care, Faculty of Medicine, University of Pécs, Rákóczi Street 2, Pécs 7623, Hungary.
Attila MisetaDepartment of Laboratory Medicine, Faculty of Medicine, University of Pécs, Ifjúság Street 13, Pécs 7624, Hungary.
István Wittmann2nd Department of Medicine and Nephrological Centre, Faculty of Medicine, University of Pécs, Pacsirta Street 1, Pécs 7624, Hungary.
University of Pecs · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hydroxyl radical converts Phe to para-, meta-, and ortho-Tyr (p-Tyr, m-Tyr, o-Tyr), while Phe is converted enzymatically to p-Tyr in the kidney and could serve as substrate for gluconeogenesis. Pathological isoforms m- and o-Tyr are supposed to be involved in development of hormone resistances. Role of Phe and the three Tyr isoforms in influencing insulin need was examined in 25 nondiabetic septic patients. Daily insulin dose (DID) and insulin-glucose product (IGP) were calculated. Serum and urinary levels of Phe and Tyr isoforms were determined using a rpHPLC-method. Urinary m-Tyr/p-Tyr ratio was higher in patients with DID and IGP over median compared to those below median (P = 0.005 and P = 0.01, resp.). Urinary m-Tyr and m-Tyr/p-Tyr ratio showed positive correlation with DID (P = 0.009 and P = 0.023, resp.) and with IGP (P = 0.004 and P = 0.008, resp.). Serum Phe was a negative predictor, while serum p-Tyr/Phe ratio was positive predictor of both DID and IGP. Urinary m-Tyr and urinary m-Tyr/p-Tyr, o-Tyr/p-Tyr, and (m-Tyr+o-Tyr)/p-Tyr ratios were positive predictors of both DID and IGP. Phe and Tyr isoforms have a predictive role in carbohydrate metabolism of nondiabetic septic patients. Phe may serve as substrate for renal gluconeogenesis via enzymatically produced p-Tyr, while hydroxyl radical derived Phe products may interfere with insulin action.

Indexed as

AgedAged, 80 and overCarbohydrate MetabolismChromatography, High Pressure LiquidFemaleGlucoseHumansHydroxyl RadicalInsulinIsomerismMaleMiddle AgedPhenylalanineShock, SepticTyrosineGlucoseHydroxyl RadicalInsulinPhenylalanineTyrosine

Identifiers

PMID26576228
PMCPMC4630663
OpenAlexW1768938649

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.