ArticleOxidative medicine and cellular longevity2015
Dandelion Extracts Protect Human Skin Fibroblasts from UVB Damage and Cellular Senescence.
Article in Oxidative medicine and cellular longevity, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 49 citations in OpenAlex.
- Bioactive Compounds from Dandelion (Foods (Basel, Switzerland) · 2026Review
- Molecular mechanisms of traditional Chinese medicine in skin aging: a narrative review.Frontiers in pharmacology · 2026Review
- In Vitro Antioxidant, Photoprotective, and Volatile Compound Profile of Supercritical COPlants (Basel, Switzerland) · 2025Article
- Pre-treatment with caffeic acid-phthalimide prevents UVB-induced oxidative stress and cytotoxicity.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2025Article
- Antioxidant and Anti-Inflammatory Effects of CrudeAntioxidants (Basel, Switzerland) · 2025Article
- Taraxasterol attenuates inflammatory responses in a 2,4-dinitrochlorobenzene-induced atopic dermatitis mouse model via inactivation of the MAPK and NF-κB pathways.Journal of molecular histology · 2025Article
- Mechanistic Role of Methanolic Extract of Taraxacum officinale Roots as Cardioprotective Against Ischemia-Reperfusion Injury-Induced Myocardial Infarction in Rats.Applied biochemistry and biotechnology · 2023Article
- Monochrome Camera Conversion: Effect on Sensitivity for Multispectral Imaging (Ultraviolet, Visible, and Infrared).Journal of imaging · 2022Article
- Protective effects of galangin against HAging · 2021Article
- Antioxidant Bioactivity of Extracts from Beach Cast Leaves ofMarine drugs · 2021Article
- Ursodeoxycholic Acid May Inhibit Environmental Aging-Associated Hyperpigmentation.Antioxidants (Basel, Switzerland) · 2021Article
- Anti-Photoaging Effect of Korean Mint (Preventive nutrition and food science · 2019Article
- HOxidative medicine and cellular longevity · 2019Article
- Dihydrocaffeic Acid Prevents UVB-Induced Oxidative Stress Leading to the Inhibition of Apoptosis and MMP-1 Expression via p38 Signaling Pathway.Oxidative medicine and cellular longevity · 2019Article
- Experimental study of the protective effect of mesosilica-supported 5-hydroxymethylfurfural on UV-induced aging of human dermal fibroblasts.RSC advances · 2018Article
- Fluorofenidone inhibits UV-A induced senescence in human dermal fibroblasts via the mammalian target of rapamycin-dependent SIRT1 pathway.The Journal of dermatology · 2018Article
- Inositol Derivatives and Phenolic Compounds from the Roots of Taraxacum coreanum.Molecules (Basel, Switzerland) · 2017Article
- Wound Healing Activity of Extracts and Formulations ofInternational journal of preventive medicine · 2017Article
- Article
- Impact on Autophagy and Ultraviolet B Induced Responses of Treatment with the MTOR Inhibitors Rapamycin, Everolimus, Torin 1, and pp242 in Human Keratinocytes.Oxidative medicine and cellular longevity · 2017Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ultraviolet (UV) irradiation causes damage in skin by generating excessive reactive oxygen species (ROS) and induction of matrix metalloproteinases (MMPs), leading to skin photoageing. Dandelion extracts have long been used for traditional Chinese medicine and native American medicine to treat cancers, hepatitis, and digestive diseases; however, less is known on the effects of dandelion extracts in skin photoageing. Here we found that dandelion leaf and flower extracts significantly protect UVB irradiation-inhibited cell viability when added before UVB irradiation or promptly after irradiation. Dandelion leaf and flower extracts inhibited UVB irradiation-stimulated MMP activity and ROS generation. Dandelion root extracts showed less action on protecting HDFs from UVB irradiation-induced MMP activity, ROS generation, and cell death. Furthermore, dandelion leaf and flower but not root extracts stimulated glutathione generation and glutathione reductase mRNA expression in the presence or absence of UVB irradiation. We also found that dandelion leaf and flower extracts help absorb UVB irradiation. In addition, dandelion extracts significantly protected HDFs from H2O2-induced cellular senescence. In conclusion, dandelion extracts especially leaf and flower extracts are potent protective agents against UVB damage and H2O2-induced cellular senescence in HDFs by suppressing ROS generation and MMP activities and helping UVB absorption.
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