ReviewComputational and mathematical methods in medicine2015
Time-Delayed Models of Gene Regulatory Networks.
Review in Computational and mathematical methods in medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- Gene Regulatory Identification Based on the Novel Hybrid Time-Delayed Method.Frontiers in genetics · 2022Article
- Mathematical Modelling of p53 Signalling during DNA Damage Response: A Survey.International journal of molecular sciences · 2021Review
- Effects of noise and time delay on E2F's expression level in a bistable Rb-E2F gene's regulatory network.IET systems biology · 2021Article
- Medium Entropy Reduction and Instability in Stochastic Systems with Distributed Delay.Entropy (Basel, Switzerland) · 2021Article
- Fokker-Planck representations of non-Markov Langevin equations: application to delayed systems.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2019Article
- Gene regulatory networks on transfer entropy (GRNTE): a novel approach to reconstruct gene regulatory interactions applied to a case study for the plant pathogen Phytophthora infestans.Theoretical biology & medical modelling · 2019Article
- Inference of Large-scale Time-delayed Gene Regulatory Network with Parallel MapReduce Cloud Platform.Scientific reports · 2018Article
- HSCVFNT: Inference of Time-Delayed Gene Regulatory Network Based on Complex-Valued Flexible Neural Tree Model.International journal of molecular sciences · 2018Article
- Degradation rate uniformity determines success of oscillations in repressive feedback regulatory networks.Journal of the Royal Society, Interface · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We discuss different mathematical models of gene regulatory networks as relevant to the onset and development of cancer. After discussion of alternative modelling approaches, we use a paradigmatic two-gene network to focus on the role played by time delays in the dynamics of gene regulatory networks. We contrast the dynamics of the reduced model arising in the limit of fast mRNA dynamics with that of the full model. The review concludes with the discussion of some open problems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.