Trial reportKorean journal of radiology
Radiofrequency versus Ethanol Ablation for Treating Predominantly Cystic Thyroid Nodules: A Randomized Clinical Trial.
Trial report in Korean journal of radiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 8 syntheses or guidelines pooled it, 123 citations in OpenAlex.
- Ablative Technologies for Thyroid Nodules: A Health Technology Assessment.Ontario health technology assessment series · 2026Pooled it
- A Systematic Review And Meta-Analysis Comparing The Prognoses Of Benign Thyroid Nodules Using Radiofrequency Ablation Versus Lobectomy.Asian Pacific journal of cancer prevention : APJCP · 2025Pooled it
- Pooled it
- Efficacy of Ethanol Ablation for Benign Thyroid Cysts and Predominantly Cystic Nodules: A Systematic Review and Meta-Analysis.Endocrinology and metabolism (Seoul, Korea) · 2021Pooled it
- Pooled it
- Complications Following Radiofrequency Ablation of Benign Thyroid Nodules: A Systematic Review.Chinese medical journal · 2017Pooled it
- Radiofrequency ablation for treatment of benign thyroid nodules: A PRISMA-compliant systematic review and meta-analysis of outcomes.Medicine · 2016Pooled it
- 2017 Thyroid Radiofrequency Ablation Guideline: Korean Society of Thyroid Radiology.Korean journal of radiologyGuideline
- Ethanol ablation of cystic thyroid nodules: institutional experience with one year follow-up.La Radiologia medica · 2026Article
- Single-session radiofrequency ablation for the treatment of benign cystic thyroid nodules: A prospective study.PloS one · 2026Article
- Improved Sealed Venous Indwelling Needle in Ultrasound-Guided Thyroid Cyst Puncture Sclerotherapy: Characteristics and Applications.Radiology research and practice · 2026Article
- The association between volume reduction ratio and time after ultrasound-guided microwave ablation for benign thyroid nodules of different compositions.Quantitative imaging in medicine and surgery · 2025Article
- Article
- Cervical plexus block enhanced pain control for unilateral thermal ablation of thyroid nodules.Gland surgery · 2024Article
- A clinical practice review of percutaneous ethanol injection for thyroid nodules: state of the art for benign, cystic lesions.Gland surgery · 2024Review
- A 6-year single-center prospective follow-up study of the efficacy of radiofrequency ablation for thyroid nodules.Frontiers in endocrinology · 2024Article
- Current role of interventional radiology in thyroid nodules.Frontiers in endocrinology · 2024Review
- Advances in clinical research on ultrasound-guided radiofrequency ablation for papillary thyroid microcarcinoma.Frontiers in oncology · 2024Article
- General Principles for the Safe Performance, Training, and Adoption of Ablation Techniques for Benign Thyroid Nodules: An American Thyroid Association Statement.Thyroid : official journal of the American Thyroid Association · 2023Article
- [Effective and Safe Application of Radiofrequency Ablation for Benign Thyroid Nodules].Journal of the Korean Society of Radiology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo compare single-session radiofrequency ablation (RFA) and ethanol ablation (EA) for treating predominantly cystic thyroid nodules (PCTNs). MATERIALS AND
methodsThis single-blind, randomized trial was approved by the Institutional Review Board of two centers and informed consent was obtained from all patients before enrollment. Fifty patients with a single PCTN (cystic portion less than 90% and greater than 50%) were randomly assigned to be treated by either RFA (25 patients) or EA (25 patients) at two hospitals. The primary outcome was the tumor volume reduction ratio (%) at the six-month follow-up and the superiority margin was set at 13% (RFA minus EA). Analysis was performed primarily in an intention-to-treat manner. The secondary outcomes were the therapeutic success rate, improvement of symptomatic and cosmetic problems, and the number of major complications.
resultsThe mean volume reduction was 87.5 ± 11.5% for RFA (n = 22) and 82.4 ± 28.6% for EA (n = 24) (p = 0.710; mean difference [95% confidence interval], 5.1% [-8.0 to 18.2]), indicating no significant difference. Regarding the secondary outcomes, therapeutic success (p = 0.490), mean symptom (p = 0.205) and cosmetic scores (p = 0.710) showed no difference. There were no major complications in either group (p > 0.99).
conclusionThe therapeutic efficacy of RFA is not superior to that of EA; therefore, EA might be preferable as the first-line treatment for PCTNs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.