ArticlePaediatric and perinatal epidemiology2016
Prenatal Stress as a Modifier of Associations between Phthalate Exposure and Reproductive Development: results from a Multicentre Pregnancy Cohort Study.
Article in Paediatric and perinatal epidemiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Systematic reviews and meta-analyses of human and animal evidence of prenatal diethylhexyl phthalate exposure and changes in male anogenital distance.Journal of toxicology and environmental health. Part B, Critical reviews · 2018Pooled it
- Associations of endocrine disrupting chemicals with anogenital distance across infancy.The Journal of clinical endocrinology and metabolism · 2026Observational
- Maternal symptoms of depression and anxiety as modifiers of the relationship between prenatal phthalate exposure and infant neurodevelopment in the Atlanta African American maternal-child cohort.Brain, behavior, & immunity - health · 2024Article
- Endocrine-disrupting chemicals: Mainstream recognition of health effects and implications for the practicing internist.Journal of internal medicine · 2024Article
- Prenatal exposures to phthalates and life events stressors in relation to child behavior at age 4-6: A combined cohort analysis.Environment international · 2024Article
- Prenatal phthalate exposure and sex steroid hormones in newborns: Taiwan Maternal and Infant Cohort Study.PloS one · 2024Article
- The intestinal microbiota as mediators between dietary contaminants and host health.Experimental biology and medicine (Maywood, N.J.) · 2023Review
- Environmental Toxicants and the Developing Brain.Biological psychiatry · 2023Review
- A study on the association of placental and maternal urinary phthalate metabolites.Journal of exposure science & environmental epidemiology · 2023Article
- The Joint Effect of Perceived Psychosocial Stress and Phthalate Exposure on Hormonal Concentrations during the Early Stage of Pregnancy: A Cross-Sectional Study.Children (Basel, Switzerland) · 2022Article
- Association of prenatal exposure to ambient air pollution with adverse birth outcomes and effect modification by socioeconomic factors.Environmental research · 2022Article
- Application of 4-way decomposition to the analysis of placental-fetal biomarkers as intermediary variables between maternal body mass index and birthweight.Frontiers in reproductive health · 2022Article
- Perinatal Exposure to Phthalates: From Endocrine to Neurodevelopment Effects.International journal of molecular sciences · 2021Review
- Psychosocial status modifies the effect of maternal blood metal and metalloid concentrations on birth outcomes.Environment international · 2021Article
- Endocrine Disrupting Chemicals and Reproductive Health in Boys and Men.Frontiers in endocrinology · 2021Review
- Interactions between chemicals and non-chemical stressors: The modifying effect of life events on the association between triclocarban, phenols and parabens with gestational length in a Puerto Rican cohort.The Science of the total environment · 2020Article
- Moderate prenatal stress may buffer the impact of Superstorm Sandy on placental genes: Stress in Pregnancy (SIP) Study.PloS one · 2020Article
- Joint impact of phthalate exposure and stressful life events in pregnancy on preterm birth.Environment international · 2019Article
- Joint Impact of Synthetic Chemical and Non-chemical Stressors on Children's Health.Current environmental health reports · 2019Review
- Observational
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundPrenatal phthalate exposure is associated with altered male reproductive tract development, and in particular, shorter anogenital distance (AGD). AGD, a sexually dimorphic index of prenatal androgen exposure, may also be altered by prenatal stress. How these exposures interact to impact AGD is unknown. Here, we examine the extent to which associations between prenatal phthalate exposure and infant AGD are modified by prenatal exposure to stressful life events (SLEs).
methodsPhthalate metabolites [including those of diethylhexyl phthalate (DEHP) and their molar sum (ΣDEHP)] were measured in first trimester urine from 738 pregnant women participating in The Infant Development and the Environment Study (TIDES). Women completed questionnaires on SLEs, and permitted infant AGD measurements at birth. Subjects were classified as 'lower' and 'higher' stress (0 first trimester SLEs vs. 1+).We estimated relationships between phthalate concentrations and AGD (by infant sex and stress group) using adjusted multiple regression interaction models.
resultsIn the lower stress group, first trimester ΣDEHP was inversely associated with two measures of male AGD: anoscrotal distance (AGD-AS; β = -1.78; 95% CI -2.97, -0.59) and anopenile distance (AGD-AP; β = -1.61; 95% CI -3.01, -0.22). By contrast, associations in the higher stress group were mostly positive and non-significant in male infants. No associations were observed in girls.
conclusionsAssociations between prenatal phthalate exposure and altered genital development were only apparent in sons of mothers who reported no SLEs during pregnancy. Prenatal stress and phthalates may interact to shape fetal development in ways that have not been previously explored.
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