ArticleOrganic letters2015
Palladium-Catalyzed Benzylic C-H Arylation of Azaarylmethylamines.
Article in Organic letters, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Synthesis of 1,3-Disubstituted 3-Azabicyclo[3.2.0]heptane Libraries for Fragment-Based Drug Discovery.Organic letters · 2026Article
- α-C-H Functionalization of Benzylamines: A Crucial Yet Challenging Transformation.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Review
- Polar Heterobenzylic C(spJournal of the American Chemical Society · 2023Article
- Palladium-catalyzed benzylic C(spChemical science · 2021Article
- Regio- and chemoselective CspChemical science · 2018Article
- Palladium-Catalyzed Triarylation of spAdvanced synthesis & catalysis · 2018Article
- Arylation of Azaarylmethylamines with Aryl Chlorides and a NiBrAdvanced synthesis & catalysis · 2017Article
- Tandem C(spAdvanced synthesis & catalysis · 2016Article
- Palladium-Catalyzed Selective α-Alkenylation of Pyridylmethyl Ethers with Vinyl Bromides.Organic letters · 2016Article
- Palladium-Catalyzed Benzylic Arylation of Pyridylmethyl Silyl Ethers: One-Pot Synthesis of Aryl(pyridyl)methanols.Organic letters · 2016Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
A direct C-H functionalization approach to produce aryl(azaaryl)methylamines from azaarylmethylamines without directing groups is described. Under conditions where the azaarylmethylamines' C-H is reversibly deprotonated, a Pd(OAc)(2)/NIXANTPHOS-based catalyst couples the resulting carbanions with various aryl halides to provide aryl(azaaryl)methylamines. This umpolung strategy directly provides tertiary amines without protecting or activating groups.
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Registered trials
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