ArticleMolecular plant pathology2016
Comparison of gene activation by two TAL effectors from Xanthomonas axonopodis pv. manihotis reveals candidate host susceptibility genes in cassava.
Article in Molecular plant pathology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- Genome Evolution in Plant Pathogenic Bacteria.Genome biology and evolution · 2026Review
- Targeting dCas9-SunTag to a Susceptibility Gene Promoter Is Sufficient for CRISPR Interference.Plant direct · 2026Article
- Proteomic analysis reveals dynamic expression related to malondialdehyde in cassava in response to cassava bacterial blight.Scientific reports · 2025Article
- Activation of three targets by a TAL effector confers susceptibility to bacterial blight of cotton.Nature communications · 2025Article
- CRISPR/Cas9-generated mutations in a sugar transporter gene reduce cassava susceptibility to bacterial blight.Plant physiology · 2024Article
- Improving cassava bacterial blight resistance by editing the epigenome.Nature communications · 2023Article
- Current status and impending progress for cassava structural genomics.Plant molecular biology · 2022Review
- The Cassava NBS-LRR Genes Confer Resistance to Cassava Bacterial Blight.Frontiers in plant science · 2022Article
- Cassava diseases caused by Xanthomonas phaseoli pv. manihotis and Xanthomonas cassavae.Molecular plant pathology · 2021Review
- An ERF121 transcription factor from Brassica oleracea is a target for the conserved TAL-effectors from different Xanthomonas campestris pv. campestris strains.Molecular plant pathology · 2021Article
- Gene tagging via CRISPR-mediated homology-directed repair in cassava.G3 (Bethesda, Md.) · 2021Article
- Microbiome-wide association studies reveal correlations between the structure and metabolism of the rhizosphere microbiome and disease resistance in cassava.Plant biotechnology journal · 2021Article
- TAL Effector Repertoires of Strains ofMicroorganisms · 2021Article
- Genome-Scale Metabolic Model ofFrontiers in genetics · 2020Article
- Engineering Disease-Resistant Cassava.Cold Spring Harbor perspectives in biology · 2019Review
- Sequence-specific nucleases as tools for enhancing disease resistance in crops.Transgenic research · 2019Article
- The role of type III effectors from Xanthomonas axonopodis pv. manihotis in virulence and suppression of plant immunity.Molecular plant pathology · 2018Article
- TALE-induced bHLH transcription factors that activate a pectate lyase contribute to water soaking in bacterial spot of tomato.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Xanthomonas axonopodis pv. manihotis (Xam) employs transcription activator-like (TAL) effectors to promote bacterial growth and symptom formation during infection of cassava. TAL effectors are secreted via the bacterial type III secretion system into plant cells, where they are directed to the nucleus, bind DNA in plant promoters and activate the expression of downstream genes. The DNA-binding activity of TAL effectors is carried out by a central domain which contains a series of repeat variable diresidues (RVDs) that dictate the sequence of bound nucleotides. TAL14Xam668 promotes virulence in Xam strain Xam668 and has been shown to activate multiple cassava genes. In this study, we used RNA sequencing to identify the full target repertoire of TAL14Xam668 in cassava, which includes over 50 genes. A subset of highly up-regulated genes was tested for activation by TAL14CIO151 from Xam strain CIO151. Although TAL14CIO151 and TAL14Xam668 differ by only a single RVD, they display differential activation of gene targets. TAL14CIO151 complements the TAL14Xam668 mutant defect, implying that shared target genes are important for TAL14Xam668 -mediated disease susceptibility. Complementation with closely related TAL effectors is a novel approach to the narrowing down of biologically relevant susceptibility genes of TAL effectors with multiple targets. This study provides an example of how TAL effector target activation by two strains within a single species of Xanthomonas can be dramatically affected by a small change in RVD-nucleotide affinity at a single site, and reflects the parameters of RVD-nucleotide interaction determined using designer TAL effectors in transient systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.