Evidence map›Paper›PMID 26575853›Full record

ReviewCurrent opinion in organ transplantation2016

Direct and indirect allograft recognition: pathways dictating graft rejection mechanisms.

Christine M Lin, Ronald G Gill

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current opinion in organ transplantation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed.

  1. Article
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  3. Review
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  6. Review
  7. Impact of Organ Donor Pretreatment With Anti-Thymocyte Globulin in a Murine Model of Allogenic Kidney Transplantation.Transplant international : official journal of the European Society for Organ Transplantation · 2024
    Article
  8. Review
  9. Review
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  11. Article
  12. Review
  13. Review
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  16. Review
  17. Article
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Christine M LinaDivision of Pulmonary Sciences and Critical Care Medicine, Department of Medicine bDepartment of Surgery and Immunology, University of Colorado Denver, Denver, Colorado, USA.
Ronald G Gill

Funding

Islet transplantation in autoimmune diabetesR01DK099187 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI GILL, RONALD G · 2014 to 2016
$912k
NIDDK NIH HHS R01 DK 099187NIDDK NIH HHS R01 DK099187
6 · The paper itself

Abstract

purpose of reviewThe T cell-dependent recognition of allogeneic tissues and organs is complicated by the fact that both donor and host antigen-presenting cells can present donor antigens to host T cells. As such, these pathways result in T cells that can be restricted to either donor ('direct') or host ('indirect') major histocompatibility complex (MHC). These pathways are well recognized, but how these distinct patterns actually dictate allograft recognition is less clear. Thus, the purpose of the review is to summarize results from preclinical animal models in an attempt to clarify the distinct forms of allograft rejection dictated by these recognition pathways. RECENT

findingsCD4 and CD8 donor MHC-restricted T cells are sufficient to reject allografts by a T-cell receptor-mediated direct ('cognate') interaction using a defined array of effector molecules. Conversely, 'noncognate' host MHC-restricted CD4 T cells must interact with intermediate host-type antigen-presenting cells and so greatly amplify the response by triggering antibody and inflammatory responses. SUMMARY: Importantly, 'cognate' CD4 and CD8 T cells have strikingly similar requirements for rejection, suggesting that this effector mechanism is dictated by the nature of allograft recognition rather than by T-cell subset. Conversely, 'noncognate' allograft recognition drives an increasingly appreciated role for inciting innate immunity in mediating allograft injury.

Indexed as

Graft RejectionAllograftsAnimalsAntigen-Presenting CellsHumansT-LymphocytesTransplantation, Homologous

Identifiers

PMID26575853
PMCPMC4701596

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.