ArticlePigment cell & melanoma research2016
Genetic variants in the vitamin D pathway genes VDBP and RXRA modulate cutaneous melanoma disease-specific survival.
Article in Pigment cell & melanoma research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 24 citations in OpenAlex.
- Review
- Vitamin D binding protein (VDBP) hijacks twist1 to inhibit vasculogenic mimicry in hepatocellular carcinoma.Theranostics · 2024Article
- Modifiable risk factors linked to the development of rheumatoid arthritis: evidence, immunological mechanisms and prevention.Frontiers in immunology · 2023Review
- Vitamin D Binding Protein (VDBP) and Its Gene Polymorphisms-The Risk of Malignant Tumors and Other Diseases.International journal of molecular sciences · 2020Review
- DBP rs16846876 and rs12512631 polymorphisms are associated with progression to AIDS naïve HIV-infected patients: a retrospective study.Journal of biomedical science · 2019Article
- Improved survival prognostication of node-positive malignant melanoma patients utilizing shotgun proteomics guided by histopathological characterization and genomic data.Scientific reports · 2019Article
- Repurposing vitamin D for treatment of human malignanciesActa pharmaceutica Sinica. B · 2019Review
- DeltaNp63-dependent super enhancers define molecular identity in pancreatic cancer by an interconnected transcription factor network.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Genetic variants in RORA and DNMT1 associated with cutaneous melanoma survival.International journal of cancer · 2018Article
- The interaction between vitamin D receptor polymorphisms and sun exposure around time of diagnosis influences melanoma survival.Pigment cell & melanoma research · 2018Article
- Genetic variants in the metzincin metallopeptidase family genes predict melanoma survival.Molecular carcinogenesis · 2018Article
- Genetic variants in the genes encoding rho GTPases and related regulators predict cutaneous melanoma-specific survival.International journal of cancer · 2017Article
- Genetic variants in the integrin signaling pathway genes predict cutaneous melanoma survival.International journal of cancer · 2017Article
- Vitamin D and Cancer Risk and Mortality: State of the Science, Gaps, and Challenges.Epidemiologic reviews · 2017Review
- No prognostic value added by vitamin D pathway SNPs to current prognostic system for melanoma survival.PloS one · 2017Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
Abstract
Single nucleotide polymorphisms (SNPs) in the vitamin D pathway genes have been implicated in cutaneous melanoma (CM) risk, but their role in CM disease-specific survival (DSS) remains obscure. We comprehensively analyzed the prognostic roles of 2669 common SNPs in the vitamin D pathway genes using data from a published genome-wide association study (GWAS) at The University of Texas M.D. Anderson Cancer Center (MDACC) and then validated the SNPs of interest in another GWAS from the Nurses' Health Study and Health Professionals Follow-up Study. Among the 2669 SNPs, 203 were significantly associated with DSS in MDACC dataset (P < 0.05 and false-positive report probability < 0.2), of which 18 were the tag SNPs. In the replication, two of these 18 SNPs showed nominal significance: the VDBP rs12512631 T > C was associated with a better DSS [combined hazards ratio (HR) = 0.66]; and the same for RXRA rs7850212 C > A (combined HR = 0.38), which were further confirmed by the Fine and Gray competing-risks regression model. Further bioinformatics analyses indicated that these loci may modulate corresponding gene methylation status.
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