ArticleeLife2015
Tachykinin acts upstream of autocrine Hedgehog signaling during nociceptive sensitization in Drosophila.
Article in eLife, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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Who cites it
56 citing papers in PubMed.
- A Tale of Two States: Similarities and Differences in Neuropeptide Signaling in Larval and Adult Drosophila.The Journal of comparative neurology · 2026Review
- A positive feedback loop between sensory and octopaminergic neurons underlies nociceptive plasticity in Drosophila larvae.PLoS genetics · 2026Article
- Toxins in disguise: Neuropeptide mimicry across animal venoms.General and comparative endocrinology · 2026Review
- ILP4 and InR regulate paclitaxel-induced hypersensitivity differently inMolecular biology of the cell · 2026Article
- Expression and RNAi characterization of neuropeptides underlying developmental regulation in the Colorado potato beetle.Frontiers in insect science · 2026Article
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- From nociception in aneural animals to human suffering: toward a comparative biology of pain.The Journal of experimental biology · 2025Review
- Caterpillars suppress nocifensive behaviours during the quiescent 'sphinx' state.Biology letters · 2025Article
- Neural substrates of cold nociception ineLife · 2025Article
- Heat-off responses of epidermal cells sensitizebioRxiv : the preprint server for biology · 2025Article
- A brief history of insect neuropeptide and peptide hormone research.Cell and tissue research · 2025Review
- Gut-Brain Dialogues in Fruit Fly (Current drug targets · 2025Review
- Involvement of neuronal tachykinin-like receptor at 86C iniScience · 2023Article
- Threat gates visual aversion via theta activity in Tachykinergic neurons.Nature communications · 2023Article
- The insulin receptor regulates the persistence of mechanical nociceptive sensitization in flies and mice.Biology open · 2023Article
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- Article
- Persistent nociceptor hyperactivity as a painful evolutionary adaptation.Trends in neurosciences · 2023Review
- Nociception in fruit fly larvae.Frontiers in pain research (Lausanne, Switzerland) · 2023Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Pain signaling in vertebrates is modulated by neuropeptides like Substance P (SP). To determine whether such modulation is conserved and potentially uncover novel interactions between nociceptive signaling pathways we examined SP/Tachykinin signaling in a Drosophila model of tissue damage-induced nociceptive hypersensitivity. Tissue-specific knockdowns and genetic mutant analyses revealed that both Tachykinin and Tachykinin-like receptor (DTKR99D) are required for damage-induced thermal nociceptive sensitization. Electrophysiological recording showed that DTKR99D is required in nociceptive sensory neurons for temperature-dependent increases in firing frequency upon tissue damage. DTKR overexpression caused both behavioral and electrophysiological thermal nociceptive hypersensitivity. Hedgehog, another key regulator of nociceptive sensitization, was produced by nociceptive sensory neurons following tissue damage. Surprisingly, genetic epistasis analysis revealed that DTKR function was upstream of Hedgehog-dependent sensitization in nociceptive sensory neurons. Our results highlight a conserved role for Tachykinin signaling in regulating nociception and the power of Drosophila for genetic dissection of nociception.
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