ArticlePloS one2015
Acute Heat Stress and Reduced Nutrient Intake Alter Intestinal Proteomic Profile and Gene Expression in Pigs.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 56 citations in OpenAlex.
- Integrated Transcriptome and Metabolome Analysis of the Porcine Small Intestine During Weaning.Genes · 2025Article
- Effect of heat stress on pig production and its mitigation strategies: a review.Tropical animal health and production · 2025Review
- Multi-tissue metabolic and transcriptomic responses to a short-term heat stress in swine.BMC genomics · 2024Article
- Translocation of gut microbes to epididymal white adipose tissue drives lipid metabolism disorder under heat stress.Science China. Life sciences · 2023Article
- Comparative analysis of whole blood transcriptomics between European and local Caribbean pigs in response to feed restriction in a tropical climate.BMC genomics · 2023Article
- The microbiome buffers tadpole hosts from heat stress: a hologenomic approach to understand host-microbe interactions under warming.The Journal of experimental biology · 2023Article
- Chronic heat stress induces the disorder of gut transport and immune function associated with endoplasmic reticulum stress in growing pigs.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2022Article
- Article
- The impact of Zearalenone on heat-stressed skeletal muscle in pigs.Journal of animal science · 2022Article
- Heat stress-induced mucosal barrier dysfunction is potentially associated with gut microbiota dysbiosis in pigs.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2022Article
- Alterations in intestinal microbiota composition coincide with impaired intestinal morphology and dysfunctional ileal immune response in growing-finishing pigs under constant chronic heat stress.Journal of animal science and biotechnology · 2022Article
- Effects of temperature on proliferation of myoblasts from donor piglets with different thermoregulatory maturities.BMC molecular and cell biology · 2021Article
- Heat stress on microbiota composition, barrier integrity, and nutrient transport in gut, production performance, and its amelioration in farm animals.Journal of animal science and technology · 2021Review
- Heat Stress Reduces Metabolic Rate While Increasing Respiratory Exchange Ratio in Growing Pigs.Animals : an open access journal from MDPI · 2021Article
- Transcriptome Analysis Identifies Candidate Genes and Signaling Pathways Associated With Feed Efficiency in Xiayan Chicken.Frontiers in genetics · 2021Article
- Proteomic study of hypothalamus in pigs exposed to heat stress.BMC veterinary research · 2020Article
- Adipose tissue-specific responses reveal an important role of lipogenesis during heat stress adaptation in pigs.Journal of animal science · 2018Article
- Short-term heat stress altered metabolism and insulin signaling in skeletal muscle.Journal of animal science · 2018Article
- Integrative approach using liver and duodenum RNA-Seq data identifies candidate genes and pathways associated with feed efficiency in pigs.Scientific reports · 2018Article
- Liver transcriptome response to hyperthermic stress in three distinct chicken lines.BMC genomics · 2016Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heat stress and reduced feed intake negatively affect intestinal integrity and barrier function. Our objective was to compare ileum protein profiles of pigs subjected to 12 hours of HS, thermal neutral ad libitum feed intake, or pair-fed to heat stress feed intake under thermal neutral conditions (pair-fed thermal neutral). 2D-Differential In Gel Electrophoresis and gene expression were performed. Relative abundance of 281 and 138 spots differed due to heat stress, compared to thermal neutral and pair-fed thermal neutral pigs, respectively. However, only 20 proteins were different due to feed intake (thermal neutral versus pair-fed thermal neutral). Heat stress increased mRNA expression of heat shock proteins and protein abundance of heat shock proteins 27, 70, 90-α and β were also increased. Heat stress reduced ileum abundance of several metabolic enzymes, many of which are involved in the glycolytic or TCA pathways, indicating a change in metabolic priorities. Stress response enzymes peroxiredoxin-1 and peptidyl-prolyl cis-trans isomerase A were decreased in pair-fed thermal neutral and thermal neutral pigs compared to heat stress. Heat stress increased mRNA abundance markers of ileum hypoxia. Altogether, these data show that heat stress directly alters intestinal protein and mRNA profiles largely independent of reduced feed intake. These changes may be related to the reduced intestinal integrity associated with heat stress.
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Registered trials
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