Evidence map›Paper›PMID 26575036›Full record

Trial reportPloS one2015

Epinephrine Improves the Efficacy of Nebulized Hypertonic Saline in Moderate Bronchiolitis: A Randomised Clinical Trial.

J Carlos Flores-González, Miguel A Matamala-Morillo, Patricia Rodríguez-Campoy, Juan J Pérez-Guerrero, Belén Serrano-Moyano, Paloma Comino-Vazquez, Encarnación Palma-Zambrano, Rocio Bulo-Concellón, Vanessa Santos-Sánchez, Alfonso M Lechuga-Sancho and 1 more

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Nebulised hypertonic saline solution for acute bronchiolitis in infants.The Cochrane database of systematic reviews · 2017
    Pooled it
  2. Article
  3. Nebulised hypertonic saline solution for acute bronchiolitis in infants.The Cochrane database of systematic reviews · 2023
    Review
  4. Review
  5. Review
  6. Nebulized epinephrine for young children with bronchiolitis.Canadian family physician Medecin de famille canadien · 2016
    Article
  7. Canadian family physician Medecin de famille canadien · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

J Carlos Flores-GonzálezDepartment of Clinical Pediatrics, Hospital Universitario Puerta del Mar, Cádiz, Spain.
Miguel A Matamala-MorilloDepartment of Clinical Pediatrics, Hospital Universitario Puerta del Mar, Cádiz, Spain.
Patricia Rodríguez-CampoyDepartment of Clinical Pediatrics, Hospital Universitario Puerta del Mar, Cádiz, Spain.
Juan J Pérez-GuerreroDepartment of Clinical Pediatrics, Hospital Universitario Puerta del Mar, Cádiz, Spain.
Belén Serrano-MoyanoDepartment of Clinical Pediatrics, Hospital Universitario Puerta del Mar, Cádiz, Spain.
Paloma Comino-VazquezDepartment of Clinical Pediatrics, Hospital Universitario Puerta del Mar, Cádiz, Spain.
Encarnación Palma-ZambranoDepartment of Clinical Pediatrics, Hospital Universitario Puerta del Mar, Cádiz, Spain.
Rocio Bulo-ConcellónDepartment of Pharmacy, Hospital Universitario Puerta del Mar, Cádiz, Spain.
Vanessa Santos-SánchezFoundation for Biomedical Research Management, Cádiz, Spain.
Alfonso M Lechuga-SanchoDepartment of Clinical Pediatrics, Hospital Universitario Puerta del Mar, Cádiz, Spain.
Bronchiolitis of Cadiz Study group (BronCaS)
Hospital Universitario Puerta del Mar · ESFoundation for Biomedical Research · US

Funding

HSRD VA SDR 10-180
6 · The paper itself

Abstract

BACKGROUND AND

aimsThere is no evidence that the epinephrine-3% hypertonic saline combination is more effective than 3% hypertonic saline alone for treating infants hospitalized with acute bronchiolitis. We evaluated the efficacy of nebulized epinephrine in 3% hypertonic saline. PATIENTS AND

methodsWe performed a randomized, double-blind, placebo-controlled clinical trial in 208 infants hospitalized with acute moderate bronchiolitis. Infants were randomly assigned to receive nebulized 3% hypertonic saline with either 3 mL of epinephrine or 3 mL of placebo, administered every four hours. The primary outcome measure was the length of hospital stay.

resultsA total of 185 infants were analyzed: 94 in the epinephrine plus 3% hypertonic saline group and 91 in the placebo plus 3% hypertonic saline group. Baseline demographic and clinical characteristics were similar in both groups. Length of hospital stay was significantly reduced in the epinephrine group as compared with the placebo group (3.94 ±1.88 days vs. 4.82 ±2.30 days, P = 0.011). Disease severity also decreased significantly earlier in the epinephrine group (P = 0.029 and P = 0.036 on days 3 and 5, respectively).

conclusionsIn our setting, nebulized epinephrine in 3% hypertonic saline significantly shortens hospital stay in hospitalized infants with acute moderate bronchiolitis compared to 3% hypertonic saline alone, and improves the clinical scores of severity from the third day of treatment, but not before.

trial registrationEudraCT 2009-016042-57.

Indexed as

Acute DiseaseAdministration, InhalationBronchiolitisBronchodilator AgentsDouble-Blind MethodEpinephrineFemaleHumansInfantLength of StayMaleNebulizers and VaporizersPlacebo EffectRespiratory RateSaline Solution, HypertonicSeverity of Illness IndexBronchodilator AgentsEpinephrineSaline Solution, Hypertonic

Identifiers

PMID26575036
PMCPMC4648584
OpenAlexW2280528332

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.