ArticleNeurogastroenterology and motility2016
Ineffective esophageal motility phenotypes following fundoplication in gastroesophageal reflux disease.
Article in Neurogastroenterology and motility, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 88 citations in OpenAlex.
- ACG Clinical Guidelines: Clinical Use of Esophageal Physiologic Testing.The American journal of gastroenterology · 2020Guideline
- Optimizing Assessment of Contraction Reserve in Ineffective Esophageal Motility: A Study of Upright Multiple Rapid Swallows.Journal of neurogastroenterology and motility · 2025Article
- Multiple Rapid Swallows: What Is the Optimal Protocol for Evaluation of Esophageal Contraction Reserve?Journal of neurogastroenterology and motility · 2025Article
- Breakthrough Contractions During Multiple Rapid Swallows on High-Resolution Esophageal Manometry: A Marker of Esophageal Dysmotility in Post-Bariatric Surgery Patients.Obesity surgery · 2025Article
- Refractory Gastroesophageal Reflux Disease: Diagnosis and Management.Journal of neurogastroenterology and motility · 2024Review
- The impact of primary peristalsis, contractile reserve, and secondary peristalsis on esophageal clearance measured by timed barium esophagogram.Neurogastroenterology and motility · 2023Article
- The role of magnetic sphincter augmentation in the gastroesophageal reflux disease treatment pathway: the gastroenterology perspective.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2023Article
- Novel Diagnostic Techniques in the Evaluation of Gastroesophageal Reflux Disease (GERD).Digestive diseases and sciences · 2023Review
- Abnormal response after multiple rapid swallow provocation is not predictive of post-operative dysphagia following a tailored fundoplication approach.Surgical endoscopy · 2023Article
- Concise Review: Applicability of High-resolution Manometry in Gastroesophageal Reflux Disease.Journal of neurogastroenterology and motility · 2022Review
- Effect of electrical stimulation therapy of the lower esophageal sphincter in GERD patients with ineffective esophageal motility.Surgical endoscopy · 2021Article
- Ineffective esophageal motility is not a contraindication to total fundoplication.Surgical endoscopy · 2021Article
- Patients with ineffective esophageal motility benefit from laparoscopic antireflux surgery.Surgical endoscopy · 2021Article
- Diagnosis and Management of Refractory Gastroesophageal Reflux Disease.Gastroenterology & hepatology · 2021Article
- Evaluation of esophageal motor function in patients with gastroesophageal reflux using multiple rapid swallows.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2021Article
- Current Advancement on the Dynamic Mechanism of Gastroesophageal Reflux Disease.International journal of biological sciences · 2021Review
- Neuronal Control of Esophageal Peristalsis and Its Role in Esophageal Disease.Current gastroenterology reports · 2019Review
- Ineffective esophageal motility: Concepts, future directions, and conclusions from the Stanford 2018 symposium.Neurogastroenterology and motility · 2019Review
- Do Vigorous Esophageal Contractions Contribute to Rigorous Phenotyping of Gastroesophageal Reflux Disease?Digestive diseases and sciences · 2019Article
- High-Resolution Manometry Diagnosis of Ineffective Esophageal Motility Is Associated with Higher Reflux Burden.Digestive diseases and sciences · 2019Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundIneffective esophageal motility (IEM) is associated with reflux disease, but its natural history is unclear. We evaluated patients undergoing repeat esophageal high resolution manometry (HRM) for symptomatic presentations after antireflux surgery (ARS) to understand the progression of IEM.
methodsPatients with repeat HRM after ARS were included. Ineffective esophageal motility was diagnosed if ≥5 sequences had distal contractile integral (DCI) <450 mmHg cm s. Augmentation of DCI following multiple rapid swallows (MRS) was assessed. The esophagogastric junction (EGJ) was interrogated using the EGJ contractile integral (EGJ-CI). Esophageal motor function was compared between patients with and without IEM. KEY
resultsSixty-eight patients (53.9 ± 1.8 years, 66.2% female) had pre- and post-ARS HRM studies 2.1 ± 0.19 years apart. Esophagogastric junction-CI augmented by a mean of 26.3% following ARS. Four IEM phenotypes were identified: 14.7% had persistent IEM, 8.8% resolved IEM after ARS, 19.1% developed new IEM, and 57.4% had no IEM at any point. Patients with IEM had a lower DCI pre- and post-ARS, lower pre-ARS EGJ CI, and lower pre-ARS-integrated relaxation pressure (p ≤ 0.02 for all comparisons); presenting symptoms and other EGJ metrics were similar (p ≥ 0.08 for all comparisons). The IEM phenotypes could be predicted by MRS DCI response patterns (p = 0.008 across groups); patients with persistent IEM had the least DCI augmentation (p = 0.007 compared to no IEM), while those who resolved IEM had DCI augmentation comparable to no IEM (p = 0.08). CONCLUSIONS & INFERENCES: Distinct phenotypes of IEM exist among symptomatic reflux patients following ARS. Provocative testing with MRS may help identify these phenotypes pre-ARS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.