Trial reportThe Journal of clinical endocrinology and metabolism2016
Dual-5α-Reductase Inhibition Promotes Hepatic Lipid Accumulation in Man.
Open access · hybridAbstract readRandomized Controlled Trial
In one paragraph
Trial report in The Journal of clinical endocrinology and metabolism, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 67 citations in OpenAlex.
- Co-administration of 5α-reductase Inhibitors Worsens the Adverse Metabolic Effects of Prescribed Glucocorticoids.The Journal of clinical endocrinology and metabolism · 2020Trial
- Trial
- Absence of Interaction Between 5α-Reductase Inhibitors and Glucocorticoids on Incidence of Myocardial Infarction in People With Type 2 Diabetes.Diabetes, obesity & metabolism · 2026Article
- Risk of Type 2 Diabetes Mellitus in New Users of 5-Alpha Reductase Inhibitors: A Nationwide Historical Cohort Study.Yonsei medical journal · 2026Article
- Cardiovascular safety of 5α-reductase inhibitors in people with benign prostatic hyperplasia and type 2 diabetes: a propensity score-matched analysis.European heart journal. Cardiovascular pharmacotherapy · 2026Article
- Metabolic Messengers: testosterone.Nature metabolism · 2026Review
- The post-finasteride syndrome: possible etiological mechanisms and symptoms.International journal of impotence research · 2025Review
- Risk of poor glycemic control in tamsulosin versus finasteride users with type 2 diabetes mellitus.Heliyon · 2025Article
- Metabolic benefits afforded by estradiol and testosterone in both sexes: clinical considerations.The Journal of clinical investigation · 2024Review
- Cell-specific AHR-driven differential gene expression in the mouse liver cell following acute TCDD exposure.BMC genomics · 2024Article
- Risks and side effects in the medical management of benign prostatic hyperplasia.Prostate international · 2024Review
- Is There an Association between 5a Reductase Inhibitors and Metabolic Syndrome? A Narrative Review of the Literature.Reviews on recent clinical trials · 2024Review
- AKR1D1 knockout mice develop a sex-dependent metabolic phenotype.The Journal of endocrinology · 2022Article
- In Vitro and In Vivo Regulation ofMolecules (Basel, Switzerland) · 2022Article
- The association of new-onset diabetes mellitus and medical therapy for benign prostatic hyperplasia: A population-based study.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2021Article
- Antisense oligonucleotide-mediated knockdown of Mpzl3 attenuates the negative metabolic effects of diet-induced obesity in mice.Physiological reports · 2021Article
- New Avenues for Treatment and Prevention of Drug-Induced Steatosis and Steatohepatitis: Much More Than Antioxidants.Advances in therapy · 2021Review
- Pathophysiology of NASH in endocrine diseases.Endocrine connections · 2021Review
- Remission of type 2 diabetes following long-term treatment with injectable testosterone undecanoate in patients with hypogonadism and type 2 diabetes: 11-year data from a real-world registry study.Diabetes, obesity & metabolism · 2020Article
- Health Risks Associated with Long-Term Finasteride and Dutasteride Use: It's Time to Sound the Alarm.The world journal of men's health · 2020Review
Corrections and comments
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Authors and funding
14 authors at 6 institutions in 2 countries.
Jonathan M HazlehurstOxford Centre for Diabetes, Endocrinology, and Metabolism (J.M.H., N.N., L.H., J.W.T.), National Institute for Health Research Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford OX3 7LE, United Kingdom; Centre for Diabetes, Endocrinology, and Metabolism (A.I.O., A.E.T., B.A.H.), Institute of Biomedical Research, School of Clinical and Experimental Medicine, School of Biosciences and Regional Phenome Centre (R.D.G., W.B.D.), Centre for Liver Research and National Institute for Health Research Liver Biomedical Research Unit (M.J.A.), and School of Sports and Exercise Sciences (J.Y.), University of Birmingham, Birmingham B15 2TH, United Kingdom; National Institute for Health Research/Wellcome Trust Clinical Research Facility (A.E.K.G.), Queen Elizabeth Hospital, Birmingham B15 2TT, United Kingdom; and Department of Medical Physics (N.P.D., R.B.F.), Queen Elizabeth Hospital, Birmingham B15 2GW, United Kingdom.
Andrei I OprescuOxford Centre for Diabetes, Endocrinology, and Metabolism (J.M.H., N.N., L.H., J.W.T.), National Institute for Health Research Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford OX3 7LE, United Kingdom; Centre for Diabetes, Endocrinology, and Metabolism (A.I.O., A.E.T., B.A.H.), Institute of Biomedical Research, School of Clinical and Experimental Medicine, School of Biosciences and Regional Phenome Centre (R.D.G., W.B.D.), Centre for Liver Research and National Institute for Health Research Liver Biomedical Research Unit (M.J.A.), and School of Sports and Exercise Sciences (J.Y.), University of Birmingham, Birmingham B15 2TH, United Kingdom; National Institute for Health Research/Wellcome Trust Clinical Research Facility (A.E.K.G.), Queen Elizabeth Hospital, Birmingham B15 2TT, United Kingdom; and Department of Medical Physics (N.P.D., R.B.F.), Queen Elizabeth Hospital, Birmingham B15 2GW, United Kingdom.
Nikolaos NikolaouOxford Centre for Diabetes, Endocrinology, and Metabolism (J.M.H., N.N., L.H., J.W.T.), National Institute for Health Research Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford OX3 7LE, United Kingdom; Centre for Diabetes, Endocrinology, and Metabolism (A.I.O., A.E.T., B.A.H.), Institute of Biomedical Research, School of Clinical and Experimental Medicine, School of Biosciences and Regional Phenome Centre (R.D.G., W.B.D.), Centre for Liver Research and National Institute for Health Research Liver Biomedical Research Unit (M.J.A.), and School of Sports and Exercise Sciences (J.Y.), University of Birmingham, Birmingham B15 2TH, United Kingdom; National Institute for Health Research/Wellcome Trust Clinical Research Facility (A.E.K.G.), Queen Elizabeth Hospital, Birmingham B15 2TT, United Kingdom; and Department of Medical Physics (N.P.D., R.B.F.), Queen Elizabeth Hospital, Birmingham B15 2GW, United Kingdom.
Riccardo Di GuidaOxford Centre for Diabetes, Endocrinology, and Metabolism (J.M.H., N.N., L.H., J.W.T.), National Institute for Health Research Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford OX3 7LE, United Kingdom; Centre for Diabetes, Endocrinology, and Metabolism (A.I.O., A.E.T., B.A.H.), Institute of Biomedical Research, School of Clinical and Experimental Medicine, School of Biosciences and Regional Phenome Centre (R.D.G., W.B.D.), Centre for Liver Research and National Institute for Health Research Liver Biomedical Research Unit (M.J.A.), and School of Sports and Exercise Sciences (J.Y.), University of Birmingham, Birmingham B15 2TH, United Kingdom; National Institute for Health Research/Wellcome Trust Clinical Research Facility (A.E.K.G.), Queen Elizabeth Hospital, Birmingham B15 2TT, United Kingdom; and Department of Medical Physics (N.P.D., R.B.F.), Queen Elizabeth Hospital, Birmingham B15 2GW, United Kingdom.
Annabel E K GrinbergsOxford Centre for Diabetes, Endocrinology, and Metabolism (J.M.H., N.N., L.H., J.W.T.), National Institute for Health Research Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford OX3 7LE, United Kingdom; Centre for Diabetes, Endocrinology, and Metabolism (A.I.O., A.E.T., B.A.H.), Institute of Biomedical Research, School of Clinical and Experimental Medicine, School of Biosciences and Regional Phenome Centre (R.D.G., W.B.D.), Centre for Liver Research and National Institute for Health Research Liver Biomedical Research Unit (M.J.A.), and School of Sports and Exercise Sciences (J.Y.), University of Birmingham, Birmingham B15 2TH, United Kingdom; National Institute for Health Research/Wellcome Trust Clinical Research Facility (A.E.K.G.), Queen Elizabeth Hospital, Birmingham B15 2TT, United Kingdom; and Department of Medical Physics (N.P.D., R.B.F.), Queen Elizabeth Hospital, Birmingham B15 2GW, United Kingdom.
Nigel P DaviesOxford Centre for Diabetes, Endocrinology, and Metabolism (J.M.H., N.N., L.H., J.W.T.), National Institute for Health Research Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford OX3 7LE, United Kingdom; Centre for Diabetes, Endocrinology, and Metabolism (A.I.O., A.E.T., B.A.H.), Institute of Biomedical Research, School of Clinical and Experimental Medicine, School of Biosciences and Regional Phenome Centre (R.D.G., W.B.D.), Centre for Liver Research and National Institute for Health Research Liver Biomedical Research Unit (M.J.A.), and School of Sports and Exercise Sciences (J.Y.), University of Birmingham, Birmingham B15 2TH, United Kingdom; National Institute for Health Research/Wellcome Trust Clinical Research Facility (A.E.K.G.), Queen Elizabeth Hospital, Birmingham B15 2TT, United Kingdom; and Department of Medical Physics (N.P.D., R.B.F.), Queen Elizabeth Hospital, Birmingham B15 2GW, United Kingdom.
Robert B FlinthamOxford Centre for Diabetes, Endocrinology, and Metabolism (J.M.H., N.N., L.H., J.W.T.), National Institute for Health Research Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford OX3 7LE, United Kingdom; Centre for Diabetes, Endocrinology, and Metabolism (A.I.O., A.E.T., B.A.H.), Institute of Biomedical Research, School of Clinical and Experimental Medicine, School of Biosciences and Regional Phenome Centre (R.D.G., W.B.D.), Centre for Liver Research and National Institute for Health Research Liver Biomedical Research Unit (M.J.A.), and School of Sports and Exercise Sciences (J.Y.), University of Birmingham, Birmingham B15 2TH, United Kingdom; National Institute for Health Research/Wellcome Trust Clinical Research Facility (A.E.K.G.), Queen Elizabeth Hospital, Birmingham B15 2TT, United Kingdom; and Department of Medical Physics (N.P.D., R.B.F.), Queen Elizabeth Hospital, Birmingham B15 2GW, United Kingdom.
Matthew J ArmstrongOxford Centre for Diabetes, Endocrinology, and Metabolism (J.M.H., N.N., L.H., J.W.T.), National Institute for Health Research Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford OX3 7LE, United Kingdom; Centre for Diabetes, Endocrinology, and Metabolism (A.I.O., A.E.T., B.A.H.), Institute of Biomedical Research, School of Clinical and Experimental Medicine, School of Biosciences and Regional Phenome Centre (R.D.G., W.B.D.), Centre for Liver Research and National Institute for Health Research Liver Biomedical Research Unit (M.J.A.), and School of Sports and Exercise Sciences (J.Y.), University of Birmingham, Birmingham B15 2TH, United Kingdom; National Institute for Health Research/Wellcome Trust Clinical Research Facility (A.E.K.G.), Queen Elizabeth Hospital, Birmingham B15 2TT, United Kingdom; and Department of Medical Physics (N.P.D., R.B.F.), Queen Elizabeth Hospital, Birmingham B15 2GW, United Kingdom.
Angela E TaylorOxford Centre for Diabetes, Endocrinology, and Metabolism (J.M.H., N.N., L.H., J.W.T.), National Institute for Health Research Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford OX3 7LE, United Kingdom; Centre for Diabetes, Endocrinology, and Metabolism (A.I.O., A.E.T., B.A.H.), Institute of Biomedical Research, School of Clinical and Experimental Medicine, School of Biosciences and Regional Phenome Centre (R.D.G., W.B.D.), Centre for Liver Research and National Institute for Health Research Liver Biomedical Research Unit (M.J.A.), and School of Sports and Exercise Sciences (J.Y.), University of Birmingham, Birmingham B15 2TH, United Kingdom; National Institute for Health Research/Wellcome Trust Clinical Research Facility (A.E.K.G.), Queen Elizabeth Hospital, Birmingham B15 2TT, United Kingdom; and Department of Medical Physics (N.P.D., R.B.F.), Queen Elizabeth Hospital, Birmingham B15 2GW, United Kingdom.
Beverly A HughesOxford Centre for Diabetes, Endocrinology, and Metabolism (J.M.H., N.N., L.H., J.W.T.), National Institute for Health Research Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford OX3 7LE, United Kingdom; Centre for Diabetes, Endocrinology, and Metabolism (A.I.O., A.E.T., B.A.H.), Institute of Biomedical Research, School of Clinical and Experimental Medicine, School of Biosciences and Regional Phenome Centre (R.D.G., W.B.D.), Centre for Liver Research and National Institute for Health Research Liver Biomedical Research Unit (M.J.A.), and School of Sports and Exercise Sciences (J.Y.), University of Birmingham, Birmingham B15 2TH, United Kingdom; National Institute for Health Research/Wellcome Trust Clinical Research Facility (A.E.K.G.), Queen Elizabeth Hospital, Birmingham B15 2TT, United Kingdom; and Department of Medical Physics (N.P.D., R.B.F.), Queen Elizabeth Hospital, Birmingham B15 2GW, United Kingdom.
Jinglei YuOxford Centre for Diabetes, Endocrinology, and Metabolism (J.M.H., N.N., L.H., J.W.T.), National Institute for Health Research Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford OX3 7LE, United Kingdom; Centre for Diabetes, Endocrinology, and Metabolism (A.I.O., A.E.T., B.A.H.), Institute of Biomedical Research, School of Clinical and Experimental Medicine, School of Biosciences and Regional Phenome Centre (R.D.G., W.B.D.), Centre for Liver Research and National Institute for Health Research Liver Biomedical Research Unit (M.J.A.), and School of Sports and Exercise Sciences (J.Y.), University of Birmingham, Birmingham B15 2TH, United Kingdom; National Institute for Health Research/Wellcome Trust Clinical Research Facility (A.E.K.G.), Queen Elizabeth Hospital, Birmingham B15 2TT, United Kingdom; and Department of Medical Physics (N.P.D., R.B.F.), Queen Elizabeth Hospital, Birmingham B15 2GW, United Kingdom.
Leanne HodsonOxford Centre for Diabetes, Endocrinology, and Metabolism (J.M.H., N.N., L.H., J.W.T.), National Institute for Health Research Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford OX3 7LE, United Kingdom; Centre for Diabetes, Endocrinology, and Metabolism (A.I.O., A.E.T., B.A.H.), Institute of Biomedical Research, School of Clinical and Experimental Medicine, School of Biosciences and Regional Phenome Centre (R.D.G., W.B.D.), Centre for Liver Research and National Institute for Health Research Liver Biomedical Research Unit (M.J.A.), and School of Sports and Exercise Sciences (J.Y.), University of Birmingham, Birmingham B15 2TH, United Kingdom; National Institute for Health Research/Wellcome Trust Clinical Research Facility (A.E.K.G.), Queen Elizabeth Hospital, Birmingham B15 2TT, United Kingdom; and Department of Medical Physics (N.P.D., R.B.F.), Queen Elizabeth Hospital, Birmingham B15 2GW, United Kingdom.
Warwick B DunnOxford Centre for Diabetes, Endocrinology, and Metabolism (J.M.H., N.N., L.H., J.W.T.), National Institute for Health Research Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford OX3 7LE, United Kingdom; Centre for Diabetes, Endocrinology, and Metabolism (A.I.O., A.E.T., B.A.H.), Institute of Biomedical Research, School of Clinical and Experimental Medicine, School of Biosciences and Regional Phenome Centre (R.D.G., W.B.D.), Centre for Liver Research and National Institute for Health Research Liver Biomedical Research Unit (M.J.A.), and School of Sports and Exercise Sciences (J.Y.), University of Birmingham, Birmingham B15 2TH, United Kingdom; National Institute for Health Research/Wellcome Trust Clinical Research Facility (A.E.K.G.), Queen Elizabeth Hospital, Birmingham B15 2TT, United Kingdom; and Department of Medical Physics (N.P.D., R.B.F.), Queen Elizabeth Hospital, Birmingham B15 2GW, United Kingdom.
Jeremy W TomlinsonOxford Centre for Diabetes, Endocrinology, and Metabolism (J.M.H., N.N., L.H., J.W.T.), National Institute for Health Research Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford OX3 7LE, United Kingdom; Centre for Diabetes, Endocrinology, and Metabolism (A.I.O., A.E.T., B.A.H.), Institute of Biomedical Research, School of Clinical and Experimental Medicine, School of Biosciences and Regional Phenome Centre (R.D.G., W.B.D.), Centre for Liver Research and National Institute for Health Research Liver Biomedical Research Unit (M.J.A.), and School of Sports and Exercise Sciences (J.Y.), University of Birmingham, Birmingham B15 2TH, United Kingdom; National Institute for Health Research/Wellcome Trust Clinical Research Facility (A.E.K.G.), Queen Elizabeth Hospital, Birmingham B15 2TT, United Kingdom; and Department of Medical Physics (N.P.D., R.B.F.), Queen Elizabeth Hospital, Birmingham B15 2GW, United Kingdom.
Institute of Biomedical Science · GBUniversity of Oxford · GBChurchill Hospital · GBNational Institute for Health Research · GBQueen Elizabeth Hospital Birmingham · GBUniversity of Birmingham · GB
Funding
British Heart Foundation FS/11/18/28633Department of HealthMedical Research Council G0802765Medical Research Council MR/M009157/1Wellcome Trust 104458/Z/14/Z
Abstract
context5α-Reductase 1 and 2 (SRD5A1, SRD5A2) inactivate cortisol to 5α-dihydrocortisol in addition to their role in the generation of DHT. Dutasteride (dual SRD5A1 and SRD5A2 inhibitor) and finasteride (selective SRD5A2 inhibitor) are commonly prescribed, but their potential metabolic effects have only recently been identified.
objectiveOur objective was to provide a detailed assessment of the metabolic effects of SRD5A inhibition and in particular the impact on hepatic lipid metabolism.
designWe conducted a randomized study in 12 healthy male volunteers with detailed metabolic phenotyping performed before and after a 3-week treatment with finasteride (5 mg od) or dutasteride (0.5 mg od). Hepatic magnetic resonance spectroscopy (MRS) and two-step hyperinsulinemic euglycemic clamps incorporating stable isotopes with concomitant adipose tissue microdialysis were used to evaluate carbohydrate and lipid flux. Analysis of the serum metabolome was performed using ultra-HPLC-mass spectrometry.
settingThe study was performed in the Wellcome Trust Clinical Research Facility, Queen Elizabeth Hospital, Birmingham, United Kingdom.
main outcome measureIncorporation of hepatic lipid was measured with MRS.
resultsDutasteride, not finasteride, increased hepatic insulin resistance. Intrahepatic lipid increased on MRS after dutasteride treatment and was associated with increased rates of de novo lipogenesis. Adipose tissue lipid mobilization was decreased by dutasteride. Analysis of the serum metabolome demonstrated that in the fasted state, dutasteride had a significant effect on lipid metabolism.
conclusionsDual-SRD5A inhibition with dutasteride is associated with increased intrahepatic lipid accumulation.
Indexed as
3-Oxo-5-alpha-Steroid 4-Dehydrogenase5-alpha Reductase InhibitorsAdipose TissueAdultCarbohydrate MetabolismDutasterideFinasterideGlucose Clamp TechniqueHumansInsulin ResistanceLipid MetabolismLiverMaleMembrane ProteinsMetabolomeSteroids3-Oxo-5-alpha-Steroid 4-Dehydrogenase5-alpha Reductase InhibitorsDutasterideFinasterideMembrane ProteinsSRD5A1 protein, humanSRD5A2 protein, humanSteroids
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.