Evidence map›Paper›PMID 26574755›Full record

Trial reportPloS one2015

(In)Consistencies in Responses to Sodium Bicarbonate Supplementation: A Randomised, Repeated Measures, Counterbalanced and Double-Blind Study.

Gabriela Froio de Araujo Dias, Vinicius da Eira Silva, Vitor de Salles Painelli, Craig Sale, Guilherme Giannini Artioli, Bruno Gualano, Bryan Saunders

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02474628 (Consistencies in Responses to Sodium Bicarbonate Supplementation), which is not on this map. Cited by 28 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 3 pooled it
5.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02474628 nacompletednot on this map

Consistencies in Responses to Sodium Bicarbonate Supplementation: a Randomised, Repeated Measures, Counterbalanced and Double-blind Study

TypeinterventionalSponsorUniversity of Sao PauloRan2013 to 2014Enrolled15ConditionsSports Nutritional Physiological PhenomenaArmssodium bicarbonate, calcium carbonate
3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 3 syntheses or guidelines pooled it, 54 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Gabriela Froio de Araujo DiasLaboratory of Applied Nutrition and Metabolism, School of Physical Education and Sport, University of Sao Paulo, São Paulo, Brazil.
Vinicius da Eira SilvaLaboratory of Applied Nutrition and Metabolism, School of Physical Education and Sport, University of Sao Paulo, São Paulo, Brazil.
Vitor de Salles PainelliLaboratory of Applied Nutrition and Metabolism, School of Physical Education and Sport, University of Sao Paulo, São Paulo, Brazil.
Craig SaleSport, Health and Performance Enhancement (SHAPE) Research Group, School of Science and Technology, Nottingham Trent University, Nottingham, United Kingdom.
Guilherme Giannini ArtioliLaboratory of Applied Nutrition and Metabolism, School of Physical Education and Sport, University of Sao Paulo, São Paulo, Brazil.
Bruno GualanoLaboratory of Applied Nutrition and Metabolism, School of Physical Education and Sport, University of Sao Paulo, São Paulo, Brazil.
Bryan SaundersLaboratory of Applied Nutrition and Metabolism, School of Physical Education and Sport, University of Sao Paulo, São Paulo, Brazil.
Universidade de São Paulo · BRNottingham Trent University · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesIntervention studies do not account for high within-individual variation potentially compromising the magnitude of an effect. Repeat administration of a treatment allows quantification of individual responses and determination of the consistency of responses. We determined the consistency of metabolic and exercise responses following repeated administration of sodium bicarbonate (SB). DESIGN AND

methods15 physically active males (age 25±4 y; body mass 76.0±7.3 kg; height 1.77±0.05 m) completed six cycling capacity tests at 110% of maximum power output (CCT110%) following ingestion of either 0.3 g∙kg-1BM of SB (4 trials) or placebo (PL, 2 trials). Blood pH, bicarbonate, base excess and lactate were determined at baseline, pre-exercise, post-exercise and 5-min post-exercise. Total work done (TWD) was recorded as the exercise outcome.

resultsSB supplementation increased blood pH, bicarbonate and base excess prior to every trial (all p ≤ 0.001); absolute changes in pH, bicarbonate and base excess from baseline to pre-exercise were similar in all SB trials (all p > 0.05). Blood lactate was elevated following exercise in all trials (p ≤ 0.001), and was higher in some, but not all, SB trials compared to PL. TWD was not significantly improved with SB vs. PL in any trial (SB1: +3.6%; SB2 +0.3%; SB3: +2.1%; SB4: +6.7%; all p > 0.05), although magnitude-based inferences suggested a 93% likely improvement in SB4. Individual analysis showed ten participants improved in at least one SB trial above the normal variation of the test although five improved in none.

conclusionsThe mechanism for improved exercise with SB was consistently in place prior to exercise, although this only resulted in a likely improvement in one trial. SB does not consistently improve high intensity cycling capacity, with results suggesting that caution should be taken when interpreting the results from single trials as to the efficacy of SB supplementation.

trial registrationClinicalTrials.gov NCT02474628.

Indexed as

Acid-Base EquilibriumAdultBicyclingDietary SupplementsDouble-Blind MethodExercise ToleranceHumansLactic AcidMaleSodium BicarbonateTreatment OutcomeLactic AcidSodium Bicarbonate

Identifiers

PMID26574755
PMCPMC4648485
OpenAlexW2174847057

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.