ArticleThe ISME journal2016
The effect of microbial colonization on the host proteome varies by gastrointestinal location.
Article in The ISME journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 33 citations in OpenAlex.
- Improved mouse models of the small intestine microbiota using region-specific sampling from humans.bioRxiv : the preprint server for biology · 2024Article
- DeepRTAlign: toward accurate retention time alignment for large cohort mass spectrometry data analysis.Nature communications · 2023Article
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- Review
- Discovery of Candidate Stool Biomarker Proteins for Biliary Atresia Using Proteome Analysis by Data-Independent Acquisition Mass Spectrometry.Proteomes · 2020Article
- Organ-level protein networks as a reference for the host effects of the microbiome.Genome research · 2020Article
- Maternal milk and fecal microbes guide the spatiotemporal development of mucosa-associated microbiota and barrier function in the porcine neonatal gut.BMC biology · 2019Article
- Developmental exposure to polychlorinated biphenyls (PCBs) in the maternal diet causes host-microbe defects in weanling offspring mice.Environmental pollution (Barking, Essex : 1987) · 2019Article
- Microcins inFrontiers in microbiology · 2019Review
- The application of omics techniques to understand the role of the gut microbiota in inflammatory bowel disease.Therapeutic advances in gastroenterology · 2019Review
- More Than Skin Deep: Autophagy Is Vital for Skin Barrier Function.Frontiers in immunology · 2018Review
- Metaproteomic analysis of human gut microbiota: where are we heading?Journal of biomedical science · 2017Review
- Microgeographic Proteomic Networks of the Human Colonic Mucosa and Their Association With Inflammatory Bowel Disease.Cellular and molecular gastroenterology and hepatology · 2016Article
- Review
- The effect of microbial challenge on the intestinal proteome of broiler chickens.Proteome science · 2016Article
- The Yin and Yang dualistic features of autophagy in thermal burn wound healing.International journal of immunopathology and pharmacologyArticle
- Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
Abstract
Endogenous intestinal microbiota have wide-ranging and largely uncharacterized effects on host physiology. Here, we used reverse-phase liquid chromatography-coupled tandem mass spectrometry to define the mouse intestinal proteome in the stomach, jejunum, ileum, cecum and proximal colon under three colonization states: germ-free (GF), monocolonized with Bacteroides thetaiotaomicron and conventionally raised (CR). Our analysis revealed distinct proteomic abundance profiles along the gastrointestinal (GI) tract. Unsupervised clustering showed that host protein abundance primarily depended on GI location rather than colonization state and specific proteins and functions that defined these locations were identified by random forest classifications. K-means clustering of protein abundance across locations revealed substantial differences in host protein production between CR mice relative to GF and monocolonized mice. Finally, comparison with fecal proteomic data sets suggested that the identities of stool proteins are not biased to any region of the GI tract, but are substantially impacted by the microbiota in the distal colon.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.