ArticlePediatrics2015
Effect of Catheter Dwell Time on Risk of Central Line-Associated Bloodstream Infection in Infants.
Article in Pediatrics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.
- Early planned removal versus expectant management of peripherally inserted central catheters to prevent infection in newborn infants.The Cochrane database of systematic reviews · 2018Pooled it
- Complications and risk factors of neonatal peripherally inserted central catheters lines.BMC pediatrics · 2026Article
- Temporal and anatomic determinants of central-line-associated bloodstream infection risk in a tertiary PICU: a 3-year time-to-event and competing-risk analysis.Frontiers in pediatrics · 2026Article
- The impact of central line-specific dwell-times for neonatal central line associated bloodstream infections.Antimicrobial resistance and infection control · 2025Article
- Central venous catheter insertion profile and complications among neonates in Saudi Arabia: a cross-sectional study.BMJ open · 2024Article
- The effect of minimizing central line days for very low birth weight infants through quality improvement.Scientific reports · 2024Article
- Central Lines and Their Complications in Neonates: A Case Report and Literature Review.Children (Basel, Switzerland) · 2023Review
- Genetic Background and Molecular Mechanisms of Juvenile Idiopathic Arthritis.International journal of molecular sciences · 2023Review
- Central Venous Catheter-Related Infectious Complications in Pediatric Surgical Patients: A Single-Center Experience.Journal of pediatric intensive care · 2022Article
- Duration of central venous catheter placement and central line-associated bloodstream infections after the adoption of prevention bundles: a two-year retrospective study.Antimicrobial resistance and infection control · 2022Article
- Identification of potential risk factors for the poor prognosis of neonatal sepsis.Medicine and pharmacy reports · 2022Article
- Unilateral nephrectomy for young infants with congenital nephrotic syndrome of the Finnish type.Clinical and experimental nephrology · 2022Article
- Line days as a determinant of central line-associated bloodstream infections in pediatric patients with tunneled femoral peripherally inserted central catheters.Pediatric radiology · 2021Article
- Article
- Ultrasound-guided supraclavicular cannulation of the brachiocephalic vein may reduce central line-associated bloodstream infection in preterm infants.European journal of pediatrics · 2020Article
- Survival Without Major Morbidity Among Very Low Birth Weight Infants in California.Pediatrics · 2020Article
- Application of peripherally inserted central catheters in critically ill newborns experience from a neonatal intensive care unit.Medicine · 2019Article
- Risk Factors for Central Line-Associated Bloodstream Infection in Critically Ill Neonates.Indian journal of pediatrics · 2019Article
- Clearance of tunneled central venous catheter associated blood stream infections in children.Journal of pediatric surgery · 2018Article
- Single-stick tunneled central venous access using the jugular veins in infants weighing less than 5 kg.Pediatric radiology · 2017Article
Corrections and comments
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Authors and funding
29 authors at 20 institutions in 1 country.
Funding
Abstract
BACKGROUND AND
objectiveCentral venous catheters in the NICU are associated with significant morbidity and mortality because of the risk of central line-associated bloodstream infections (CLABSIs). The purpose of this study was to determine the effect of catheter dwell time on risk of CLABSI.
methodsRetrospective cohort study of 13,327 infants with 15,567 catheters (93% peripherally inserted central catheters [PICCs], 7% tunneled catheters) and 256,088 catheter days cared for in 141 NICUs. CLABSI was defined using National Health Surveillance Network criteria. We defined dwell time as the number of days from line insertion until either line removal or day of CLABSI. We generated survival curves for each week of dwell time and estimated hazard ratios for CLABSI at each week by using a Cox proportional hazards frailty model. We controlled for postmenstrual age and year, included facility as a random effect, and generated separate models by line type.
resultsMedian postmenstrual age was 29 weeks (interquartile range 26-33). The overall incidence of CLABSI was 0.93 per 1000 catheter days. Increased dwell time was not associated with increased risk of CLABSI for PICCs. For tunneled catheters, infection incidence was significantly higher in weeks 7 and 9 compared with week 1.
conclusionsClinicians should not routinely replace uninfected PICCs for fear of infection but should consider removing tunneled catheters before week 7 if no longer needed. Additional studies are needed to determine what daily maintenance practices may be associated with decreased risk of infection, especially for tunneled catheters.
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