ArticleThe EMBO journal2016
Danger peptide receptor signaling in plants ensures basal immunity upon pathogen-induced depletion of BAK1.
Article in The EMBO journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.
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Who cites it
75 citing papers in PubMed, 150 citations in OpenAlex.
- S-acylation switches the fate of a plant peptide precursor in cell wall damage responses.Science advances · 2026Article
- Two pear phytocytokines PbePep4 and PdrPep6 interfamilially elicit broad-spectrum immunity against various pathogens in crops.Horticulture research · 2026Article
- Humidity-driven ABA depletion determines plant-pathogen competition for leaf water.Nature communications · 2025Article
- SUMOylation of BAK1 regulates its co-receptor function for specifically activating brassinosteroid response.Plant communications · 2025Article
- SERK5 genetically compensates for the loss of BAK1 and BKK1 in regulating elf18-triggered immune signaling inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- The receptor-like kinase SlLRR-RLK94 as a positive regulator of tomato resistance to Phytophthora infestans.Plant cell reports · 2025Article
- Mastering the balance: BAK1's dual roles in steering plant growth and immunity.Horticulture research · 2025Article
- Plant metacaspases orchestrate wound-induced pathways for immunity and tissue regeneration.The Plant journal : for cell and molecular biology · 2025Article
- Orchestration of plant PRR- and NLR-mediated immunity: Protein kinases and beyond.Molecular cell · 2025Review
- Role of Tyrosine Phosphorylation in PEP1 Receptor 1(PEPR1) inPlants (Basel, Switzerland) · 2025Article
- Regreening mechanisms in cucumber: insights from a CsSIG2 mutation affecting chloroplast development.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- The molecular framework balancing growth and defense in response to plant elicitor peptide-induced signals in Arabidopsis.The Plant cell · 2024Article
- The PpPep2-Triggered PTI-like Response in Peach Trees Is Mediated by miRNAs.International journal of molecular sciences · 2024Article
- Proteolysis in plant immunity.The Plant cell · 2024Review
- Pull the fuzes: Processing protein precursors to generate apoplastic danger signals for triggering plant immunity.Plant communications · 2024Review
- Unlocking Nature's Defense: Plant Pattern Recognition Receptors as Guardians Against Pathogenic Threats.Molecular plant-microbe interactions : MPMI · 2024Review
- Differential expression of the genes encoding immune system components in response to3 Biotech · 2024Article
- BAK-up: the receptor kinase BAK-TO-LIFE 2 enhances immunity when BAK1 is lacking.Stress biology · 2023Article
- Article
- Amino Acid Availability Determines Plant Immune Homeostasis in the Rhizosphere Microbiome.mBio · 2023Article
15 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pathogens infect a host by suppressing defense responses induced upon recognition of microbe-associated molecular patterns (MAMPs). Despite this suppression, MAMP receptors mediate basal resistance to limit host susceptibility, via a process that is poorly understood. The Arabidopsis leucine-rich repeat (LRR) receptor kinase BAK1 associates and functions with different cell surface LRR receptors for a wide range of ligands, including MAMPs. We report that BAK1 depletion is linked to defense activation through the endogenous PROPEP peptides (Pep epitopes) and their LRR receptor kinases PEPR1/PEPR2, despite critical defects in MAMP signaling. In bak1-knockout plants, PEPR elicitation results in extensive cell death and the prioritization of salicylate-based defenses over jasmonate-based defenses, in addition to elevated proligand and receptor accumulation. BAK1 disruption stimulates the release of PROPEP3, produced in response to Pep application and during pathogen challenge, and renders PEPRs necessary for basal resistance. These findings are biologically relevant, since specific BAK1 depletion coincides with PEPR-dependent resistance to the fungal pathogen Colletotrichum higginsianum. Thus, the PEPR pathway ensures basal resistance when MAMP-triggered defenses are compromised by BAK1 depletion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.