ArticleCerebral cortex (New York, N.Y. : 1991)2016
Development of Synaptic Boutons in Layer 4 of the Barrel Field of the Rat Somatosensory Cortex: A Quantitative Analysis.
Article in Cerebral cortex (New York, N.Y. : 1991), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- The synaptic organization of the human temporal lobe neocortex by high-resolution transmission, focused ion beam scanning, and electron microscopic tomography.Anatomical science international · 2025Review
- Article
- Astrocyte glypican 5 regulates synapse maturation and stabilization.Cell reports · 2025Article
- Axonal energy metabolism, and the effects in aging and neurodegenerative diseases.Molecular neurodegeneration · 2023Review
- Article
- Emergence of local and global synaptic organization on cortical dendrites.Nature communications · 2021Article
- 3D Synaptic Organization of the Rat CA1 and Alterations Induced by Cocaine Self-Administration.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Spatio-temporal dynamics of neocortical presynaptic terminal development using multi-photon imaging of the corpus callosum in vivo.Scientific reports · 2019Article
- Diversity and Function of Somatostatin-Expressing Interneurons in the Cerebral Cortex.International journal of molecular sciences · 2019Review
- Quantitative 3D Ultrastructure of Thalamocortical Synapses from the "Lemniscal" Ventral Posteromedial Nucleus in Mouse Barrel Cortex.Cerebral cortex (New York, N.Y. : 1991) · 2018Article
- Large Volume Electron Microscopy and Neural Microcircuit Analysis.Frontiers in neural circuits · 2018Review
- The Development of Nociceptive Network Activity in the Somatosensory Cortex of Freely Moving Rat Pups.Cerebral cortex (New York, N.Y. : 1991) · 2016Article
- Developmental Changes in Electrophysiological Properties and a Transition from Electrical to Chemical Coupling between Excitatory Layer 4 Neurons in the Rat Barrel Cortex.Frontiers in neural circuits · 2016Article
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Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Understanding the structural and functional mechanisms underlying the development of individual brain microcircuits is critical for elucidating their computational properties. As synapses are the key structures defining a given microcircuit, it is imperative to investigate their development and precise structural features. Here, synapses in cortical layer 4 were analyzed throughout the first postnatal month using high-end electron microscopy to generate realistic quantitative 3D models. Besides their overall geometry, the size of active zones and the pools of synaptic vesicles were analyzed. At postnatal day 2 only a few shaft synapses were found, but spine synapses steadily increased with ongoing corticogenesis. From postnatal day 2 to 30 synaptic boutons significantly decreased in size whereas that of active zones remained nearly unchanged despite a reshaping. During the first 2 weeks of postnatal development, a rearrangement of synaptic vesicles from a loose distribution toward a densely packed organization close to the presynaptic density was observed, accompanied by the formation of, first a putative readily releasable pool and later a recycling and reserve pool. The quantitative 3D reconstructions of synapses will enable the comparison of structural and functional aspects of signal transduction thus leading to a better understanding of networks in the developing neocortex.
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