ArticleBritish journal of clinical pharmacology2016
Antidepressants and antipsychotics classified with torsades de pointes arrhythmia risk and mortality in older adults - a Swedish nationwide study.
Article in British journal of clinical pharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 88 citations in OpenAlex.
- Prescribed drugs and comorbidities as risk factors for Torsades de Pointes arrhythmia: a Swedish population-based cohort study.European journal of clinical pharmacology · 2026Article
- Risk of adverse outcomes associated with mirtazapine compared to sertraline use among older people living in long-term care facilities.Age and ageing · 2025Article
- Age of onset for increased dose-adjusted serum concentrations of antidepressants and association with sex and genotype: An observational study of 34,777 individuals.European journal of clinical pharmacology · 2024Observational
- The cardiovascular safety of tricyclic antidepressants in overdose and in clinical use.Therapeutic advances in psychopharmacology · 2024Review
- Effects of Toxic Lithium Levels on ECG-Findings from the LiSIE Retrospective Cohort Study.Journal of clinical medicine · 2022Article
- The Risk of Fatal Arrhythmias in Post-Myocardial Infarction Depression in Association With Venlafaxine.Cureus · 2022Review
- Fluphenazine decanoate-induced bradycardia: A case report.Neuropsychopharmacology reports · 2022Article
- Propensity score-matching analysis comparing safety outcomes of appetite-stimulating medications in oncology patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Article
- Prevalence of potentially harmful multidrug interactions on medication lists of elderly ambulatory patients.BMC geriatrics · 2021Article
- The Cardiovascular Effects of Newer Antidepressants in Older Adults and Those With or At High Risk for Cardiovascular Diseases.CNS drugs · 2020Review
- Phosphodiesterase 2 inhibitor Hcyb1 reverses corticosterone-induced neurotoxicity and depression-like behavior.Psychopharmacology · 2020Article
- Drug use and torsades de pointes cardiac arrhythmias in Sweden: a nationwide register-based cohort study.BMJ open · 2020Article
- Effects of antidepressants on QT interval in people with mental disorders.Archives of medical science : AMS · 2020Review
- Factors Associated with Mortality Including Nursing Home Transitions: A Retrospective Analysis of 25,418 People Prescribed Anti-Dementia Drugs in Northern Ireland.Journal of Alzheimer's disease : JAD · 2020Article
- Association Between Antidepressant Drug Use and Hip Fracture in Older People Before and After Treatment Initiation.JAMA psychiatry · 2019Article
- The Use of Antipsychotic Drugs for Treating Behavioral Symptoms in Alzheimer's Disease.Frontiers in pharmacology · 2019Review
- A literature-based algorithm for the assessment, management, and monitoring of drug-induced QTc prolongation in the psychiatric population.Neuropsychiatric disease and treatment · 2019Review
- Prevalence of Torsades de Pointes inducing drugs usage among elderly outpatients in North Jordan Hospitals.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2018Article
- Mechanisms Underlying the Actions of Antidepressant and Antipsychotic Drugs That Cause Sudden Cardiac Arrest.Arrhythmia & electrophysiology review · 2018Review
- Evaluating the risk of QTc prolongation associated with antidepressant use in older adults: a review of the evidence.Therapeutic advances in drug safety · 2018Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThe aim of the study was to examine mortality risk associated with use of antidepressants and antipsychotics classified with torsades de pointes (TdP) risk in elderly.
methodsA matched case-control register study was conducted in people 65 years and older dying outside hospital from 2008-2013 (n = 286,092) and matched controls (n = 1,430,460). The association between prescription of antidepressants and antipsychotics with various TdP risk according to CredibleMeds (www.crediblemeds.org) and all-cause mortality was studied by multivariate conditional logistic regression adjusted for comorbidity and several other confounders.
resultsUse of antidepressants classified with known or possible TdP risk, was associated with higher adjusted risk for mortality (OR 1.53, 95% CI 1.51, 1.56 and OR 1.63, 95% CI 1.61, 1.67, respectively) compared with antidepressants classified with conditional TdP risk (OR 1.25, 95% CI 1.22, 1.28) or without TdP classification (OR 0.99, 95% CI 0.94, 1.05). Antipsychotics classified with known TdP risk were associated with higher risk (OR 4.57, 95% CI 4.37, 4.78) than antipsychotics with possible risk (OR 2.58, 95% CI 2.52, 2.64) or without TdP classification (OR 2.14, 95% CI 2.03, 2.65). The following risk ranking was observed for commonly used antidepressants: mirtazapine > citalopram > sertraline > amitriptyline and for antipsychotics: haloperidol > risperidone >olanzapine > quetiapine.
conclusionThe CredibleMeds system predicted drug-associated risk for mortality in the elderly at the risk class level. Among antipsychotics, haloperidol, and among antidepressants, mirtazapine and citalopram, were associated with the highest risks. The results suggest that the TdP risk with antidepressants and antipsychotics should be taken into consideration when prescribing to the elderly.
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