Genome Analysis of Kingella kingae Strain KWG1 Reveals How a β-Lactamase Gene Inserted in the Chromosome of This Species.

Philippe Bidet, Romain Basmaci, Julien Guglielmini, Catherine Doit, Christelle Jost, André Birgy, Stéphane Bonacorsi

Open access · bronzeAbstract read

In one paragraph

Article in Antimicrobial agents and chemotherapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it

0cells of the map it votes in

8citing papers in PubMed

1.4field-weighted citation impact, top 21% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 18 citations in OpenAlex.

Fastidious or rarely isolated gram-negative rods with a particular focus onClinical microbiology reviews · 2025
Review
Acquisition, co-option, and duplication of the rtx toxin system and the emergence of virulence in Kingella.Nature communications · 2023
Article
Pathogenic determinants ofFrontiers in pediatrics · 2022
Review
Identification of integrative and conjugative elements in pathogenic and commensalMicrobial genomics · 2020
Article
A New Highly Sensitive and Specific Real-Time PCR Assay Targeting the Malate Dehydrogenase Gene of Kingella kingae and Application to 201 Pediatric Clinical Specimens.Journal of clinical microbiology · 2018
Article
Extensive Gene Amplification as a Mechanism for Piperacillin-Tazobactam Resistance in Escherichia coli.mBio · 2018
Article
Molecular Tests That Target the RTX Locus Do Not Distinguish between Kingella kingae and the Recently Described Kingella negevensis Species.Journal of clinical microbiology · 2017
Article
A modified multilocus sequence typing protocol to genotype Kingella kingae from oropharyngeal swabs without bacterial isolation.BMC microbiology · 2017
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Philippe BidetINSERM, IAME, UMR 1137, Paris, France Université Paris Diderot, Sorbonne Paris Cité, IAME, UMR 1137, Paris, France AP-HP, Laboratoire de Microbiologie, Hôpital Robert-Debré, Paris, France.

Romain BasmaciINSERM, IAME, UMR 1137, Paris, France Université Paris Diderot, Sorbonne Paris Cité, IAME, UMR 1137, Paris, France AP-HP, Laboratoire de Microbiologie, Hôpital Robert-Debré, Paris, France.

Julien GuglielminiINSERM, IAME, UMR 1137, Paris, France Université Paris Diderot, Sorbonne Paris Cité, IAME, UMR 1137, Paris, France.

Catherine DoitINSERM, IAME, UMR 1137, Paris, France Université Paris Diderot, Sorbonne Paris Cité, IAME, UMR 1137, Paris, France AP-HP, Laboratoire de Microbiologie, Hôpital Robert-Debré, Paris, France.

Christelle JostINSERM, IAME, UMR 1137, Paris, France Université Paris Diderot, Sorbonne Paris Cité, IAME, UMR 1137, Paris, France AP-HP, Laboratoire de Microbiologie, Hôpital Robert-Debré, Paris, France.

André BirgyINSERM, IAME, UMR 1137, Paris, France Université Paris Diderot, Sorbonne Paris Cité, IAME, UMR 1137, Paris, France.

Stéphane BonacorsiINSERM, IAME, UMR 1137, Paris, France Université Paris Diderot, Sorbonne Paris Cité, IAME, UMR 1137, Paris, France AP-HP, Laboratoire de Microbiologie, Hôpital Robert-Debré, Paris, France stephane.bonacorsi@rdb.aphp.fr.

Délégation Paris 7 · FRAssistance Publique – Hôpitaux de Paris · FRSorbonne Paris Cité · FRUniversité Paris Cité · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We describe the genome of a penicillinase-producing Kingella kingae strain (KWG1), the first to be isolated in continental Europe, whose bla(TEM-1) gene was, for the first time in this species, found to be chromosomally inserted. The bla(TEM) gene is located in an integrative and conjugative element (ICE) inserted in Met-tRNA and comprising genes that encode resistance to sulfonamides, streptomycin, and tetracycline. This ICE is homologous to resistance-conferring plasmids of K. kingae and other Gram-negative bacteria.

Indexed as

Gene Expression Regulation, BacterialGenome, BacterialAnti-Bacterial AgentsBacterial Proteinsbeta-LactamasesChromosome MappingChromosomes, BacterialDrug Resistance, BacterialGene OntologyHumansKingella kingaeMolecular Sequence AnnotationNeisseriaceae InfectionsPlasmidsStreptomycinSulfonamidesAnti-Bacterial AgentsBacterial Proteinsbeta-LactamasesStreptomycinSulfonamidesTetracycline

Identifiers

PMID26574009

DOI10.1128/AAC.02192-15

PMCPMC4704243

OpenAlexW2277057240

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.