ArticleeLife2015
Reward signal in a recurrent circuit drives appetitive long-term memory formation.
Article in eLife, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers.
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Who cites it
84 citing papers in PubMed, 179 citations in OpenAlex.
- Article
- Creating true and false memories from forgotten information in Drosophila.Nature neuroscience · 2026Article
- Selective octopaminergic tuning of mushroom body circuits during memory formation.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Re-exposure to reward re-evaluates related memories.Current biology : CB · 2026Article
- A temporally restricted function of the dopamine receptor Dop1R2 during memory formation.eLife · 2025Article
- Dynamics of two distinct memory interactions during water seeking inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
- A split-GAL4 driver line resource foreLife · 2025Article
- Dopamine neurons that inform Drosophila olfactory memory have distinct, acute functions driving attraction and aversion.PLoS biology · 2024Article
- Review
- Article
- Skewing information flow through pre- and postsynaptic plasticity in the mushroom bodies ofLearning & memory (Cold Spring Harbor, N.Y.) · 2024Review
- Roles of feedback and feed-forward networks of dopamine subsystems: insights fromLearning & memory (Cold Spring Harbor, N.Y.) · 2024Review
- Beyond prediction error: 25 years of modeling the associations formed in the insect mushroom body.Learning & memory (Cold Spring Harbor, N.Y.) · 2024Review
- An integrative sensor of body states: how the mushroom body modulates behavior depending on physiological context.Learning & memory (Cold Spring Harbor, N.Y.) · 2024Review
- Review
- Article
- Prediction error drives associative learning and conditioned behavior in a spiking model of Drosophila larva.iScience · 2024Article
- Forgotten memory storage and retrieval in Drosophila.Nature communications · 2023Article
- Reward expectations direct learning and drive operant matching inProceedings of the National Academy of Sciences of the United States of America · 2023Article
24 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
Abstract
Dopamine signals reward in animal brains. A single presentation of a sugar reward to Drosophila activates distinct subsets of dopamine neurons that independently induce short- and long-term olfactory memories (STM and LTM, respectively). In this study, we show that a recurrent reward circuit underlies the formation and consolidation of LTM. This feedback circuit is composed of a single class of reward-signaling dopamine neurons (PAM-α1) projecting to a restricted region of the mushroom body (MB), and a specific MB output cell type, MBON-α1, whose dendrites arborize that same MB compartment. Both MBON-α1 and PAM-α1 neurons are required during the acquisition and consolidation of appetitive LTM. MBON-α1 additionally mediates the retrieval of LTM, which is dependent on the dopamine receptor signaling in the MB α/β neurons. Our results suggest that a reward signal transforms a nascent memory trace into a stable LTM using a feedback circuit at the cost of memory specificity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.