Evidence map›Paper›PMID 26573919›Full record

ArticleTranslational stroke research2016

Ginkgo biloba Extract Prevents Female Mice from Ischemic Brain Damage and the Mechanism Is Independent of the HO1/Wnt Pathway.

Jatin Tulsulkar, Bryan Glueck, Terry D Hinds, Zahoor A Shah

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational stroke research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
10.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.

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  15. Neuropsychiatric disease and treatment · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jatin TulsulkarDepartment of Medicinal and Biological Chemistry, University of Toledo, 3000 Arlington Avenue, Toledo, OH, 43614, USA.
Bryan GlueckDepartment of Medicinal and Biological Chemistry, University of Toledo, 3000 Arlington Avenue, Toledo, OH, 43614, USA.
Terry D HindsCenter for Hypertension and Personalized Medicine, Department of Physiology and Pharmacology, College of Medicine and Life Sciences, University of Toledo, Toledo, OH, USA.
Zahoor A ShahDepartment of Medicinal and Biological Chemistry, University of Toledo, 3000 Arlington Avenue, Toledo, OH, 43614, USA. zahoor.shah@utoledo.edu.
University of Toledo · US

Funding

Antioxidant-PPARalpha interaction and hypertensionK01HL125445 · NHLBI · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI HINDS, TERRY D · 2015 to 2019
$779k
Neuroprotective Effect of Ginkgo Biloba and its Bioactive Components IschemiaR00AT004197 · NCCIH · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI SHAH, ZAHOOR AHMAD · 2010 to 2012
$737k
NCCIH NIH HHS R00 AT004197NCCIH NIH HHS R00AT004197NHLBI NIH HHS K01 HL125445NHLBI NIH HHS K01HL125445NIMHD NIH HHS L32 MD009154NIMHD NIH HHS L32MD009154
6 · The paper itself

Abstract

It is well known that gender differences exist in experimental or clinical stroke with respect to brain damage and loss of functional outcome. We have previously reported neuroprotective properties of Ginkgo biloba/EGb 761® (EGb 761) in transient and permanent mouse models of brain ischemia using male mice, and the mechanism of action was attributed to the upregulation of the heme oxygenase 1 (HO1)/Wnt pathway. Here, we sought to investigate whether EGb 761's protective effect in ovariectomized female mice following stroke is also mediated by the HO1/Wnt pathway. Female mice were ovariectomized (OVX) to remove the protective effect of estrogen and were treated with EGb 761 for 7 days prior to inducing permanent middle cerebral artery occlusion (pMCAO) and allowed to survive for an additional 7 days. At day 8, animals were sacrificed, and the brains were harvested for infarct volume analysis, western blots, and immunohistochemistry. The OVX female mice treated with EGb 761 showed significantly lower infarct size as compared to Veh/OVX animals. EGb 761 treatment in female mice inhibited apoptosis by preventing caspase-3 cleavage and blocking the extrinsic apoptotic pathway. EGb 761 pretreatment significantly enhanced neurogenesis in OVX mice as compared to the Veh/OVX group and significantly upregulated androgen receptor expression with no changes in HO1/Wnt signaling. These results suggest that EGb 761 prevented brain damage in OVX female mice by improving grip strength and neurological deficits, and the mechanism of action is not through HO1/Wnt but via blocking the extrinsic apoptotic pathway.

Indexed as

AnimalsBrainBrain InfarctionBrain InjuriesCaspase 3Chlorocebus aethiopsCOS CellsDisease Models, AnimalFemaleGene Expression RegulationGinkgo bilobaGinkgo ExtractHand StrengthHeme Oxygenase-1Infarction, Middle Cerebral ArteryMiceCaspase 3Ginkgo biloba extractGinkgo ExtractHeme Oxygenase-1Plant ExtractsVascular Endothelial Growth Factor AGender differencesGinkgo bilobaHeme oxygenase 1StrokeWnt signaling

Identifiers

PMID26573919
PMCPMC4775293
OpenAlexW2263871468

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.