ArticleBMC infectious diseases2015
Spatial epidemiology and serologic cohorts increase the early detection of leprosy.
Article in BMC infectious diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 4 of them syntheses that pooled it.
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Who cites it
34 citing papers in PubMed, 4 syntheses or guidelines pooled it, 83 citations in OpenAlex.
- Prevalence of paucibacillary cases of leprosy in Brazil: a 20-year systematic review and meta-analysis.Frontiers in medicine · 2024Pooled it
- Factors associated with the development of leprosy in Brazilian contacts: a systematic review.Revista do Instituto de Medicina Tropical de Sao Paulo · 2022Pooled it
- Detection of anti-M. leprae antibodies in children in leprosy-endemic areas: A systematic review.PLoS neglected tropical diseases · 2021Pooled it
- Effectiveness of spatially targeted interventions for control of HIV, tuberculosis, leprosy and malaria: a systematic review.BMJ open · 2021Pooled it
- Longitudinal assessment of anti-PGL-I serology in contacts of leprosy patients in Bangladesh.PLoS neglected tropical diseases · 2017Trial
- A Multiepitope Protein Based on Selected Synthetic Peptides Enables Effective Serological Screening of Exposure toACS omega · 2026Article
- Spatial associations of Hansen's disease and schistosomiasis in endemic regions of Minas Gerais, Brazil.PLoS neglected tropical diseases · 2024Article
- Leprosy.Nature reviews. Disease primers · 2024Review
- The Neurological Impact of Leprosy: Manifestations and Treatment Approaches.Neurology international · 2024Review
- Specialized active leprosy search strategies in an endemic area of the Brazilian Amazon identifies a hypermutatedFrontiers in medicine · 2023Article
- Profile of the leprosy endemic in the district of Murrupula, Nampula, Mozambique: A population-based study.Revista da Sociedade Brasileira de Medicina Tropical · 2023Article
- Leprosy among children in an area without primary health care coverage in Caratateua Island, Brazilian Amazon.Frontiers in medicine · 2023Article
- Can anti-PGL-I antibody isotypes differentiate leprosy contacts and leprosy patients?Pathogens and global health · 2022Article
- Spatio-temporal analysis of leprosy risks in a municipality in the state of Mato Grosso-Brazilian Amazon: results from the leprosy post-exposure prophylaxis program in Brazil.Infectious diseases of poverty · 2022Article
- Determining target populations for leprosy prophylactic interventions: a hotspot analysis in Indonesia.BMC infectious diseases · 2022Article
- Modulation of the Response toFrontiers in microbiology · 2022Review
- The state of the leprosy epidemic in Yunnan, China 2011-2020: A spatial and spatiotemporal analysis, highlighting areas for intervention.PLoS neglected tropical diseases · 2021Article
- Innovative tracking, active search and follow-up strategies for new leprosy cases in the female prison population.PLoS neglected tropical diseases · 2021Article
- Active search strategies, clinicoimmunobiological determinants and training for implementation research confirm hidden endemic leprosy in inner São Paulo, Brazil.PLoS neglected tropical diseases · 2021Article
- [Combined use of serologic markers and spatial analysis for epidemiological surveillance of leprosyUso conjunto de los marcadores serológicos y del análisis espacial en la vigilancia epidemiológica de la lepra].Revista panamericana de salud publica = Pan American journal of public health · 2021Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLeprosy remains an important public health problem in some specific high-burden pockets areas, including the Brazilian Amazon region, where it is hyperendemic among children.
methodsWe selected two elementary public schools located in areas most at risk (cluster of leprosy or hyperendemic census tract) to clinically evaluate their students. We also followed anti-PGL-I seropositive and seronegative individuals and households for 2 years to compare the incidence of leprosy in both groups.
resultsLeprosy was detected in 11 (8.2 %) of 134 school children in high risk areas. The difference in the prevalence was statistically significant (p < .05) compared to our previous findings in randomly selected schools (63/1592; 3.9 %). The 2-year follow-up results showed that 22.3 and 9.4 % of seropositive and seronegative individuals, respectively, developed leprosy (p = .027). The odds of developing overt disease in seropositive people were 2.7 times that of negative people (p < .01), indicating that a follow-up of 10 seropositives has a >90 % probability to detect at least one new case in 2 years. The odds of clinical leprosy were also higher in "positive houses" compared to "negative houses" (p < .05), indicating that a follow-up of ten people living in households with at least one seropositive dweller have a 85 % probability to detect at least one new case in 2 years.
conclusionsTargeted screening involving school-based surveillance planned using results obtained by spatial analysis and targeted household and individual continuous surveillance based on serologic data should be applied to increase the early detection of new leprosy cases.
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