ArticleMolecular and cellular biology1989
Transient expression of the proto-oncogene int-1 during differentiation of P19 embryonal carcinoma cells.
Article in Molecular and cellular biology, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Mechanisms Regulating Stemness and Differentiation in Embryonal Carcinoma Cells.Stem cells international · 2017Review
- The gold (III) porphyrin complex, gold-2a, suppresses WNT1 expression in breast cancer cells by enhancing the promoter association of YY1.American journal of translational research · 2011Article
- Overexpression of Stra13, a novel retinoic acid-inducible gene of the basic helix-loop-helix family, inhibits mesodermal and promotes neuronal differentiation of P19 cells.Genes & development · 1997Article
- Flp recombinase promotes site-specific DNA recombination in embryonic stem cells and transgenic mice.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- The promoter of the Xwnt-5C gene contains octamer and AP-2 motifs functional in Xenopus embryos.Nucleic acids research · 1994Article
- Wnt-1-inducing factor-1: a novel G/C box-binding transcription factor regulating the expression of Wnt-1 during neuroectodermal differentiation.Molecular and cellular biology · 1993Article
- The Wnt-1 (int-1) oncogene promoter and its mechanism of activation by insertion of proviral DNA of the mouse mammary tumor virus.Molecular and cellular biology · 1990Article
- Wnt-3, a gene activated by proviral insertion in mouse mammary tumors, is homologous to int-1/Wnt-1 and is normally expressed in mouse embryos and adult brain.Proceedings of the National Academy of Sciences of the United States of America · 1990Article
- Secreted int-1 protein is associated with the cell surface.Molecular and cellular biology · 1990Article
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Authors and funding
4 authors.
Funding
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Abstract
In mouse embryos, the int-1 proto-oncogene is transiently expressed in areas of the developing neural system. Retinoic acid-treated P19 embryonal carcinoma cells have often been used as an in vitro model for the molecular basis of neural development. We shown here that int-1 is transiently expressed in differentiated P19 cells. The time course and retinoic acid dose dependence of int-1 expression suggest that the gene is specifically expressed during early neural differentiation. P19 cells may be a useful model to assist in the study, at the cellular level, of the role of int-1 in neural development.
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