ArticleHypertension (Dallas, Tex. : 1979)2016
Extreme Air Pollution Conditions Adversely Affect Blood Pressure and Insulin Resistance: The Air Pollution and Cardiometabolic Disease Study.
Open access · greenAbstract read
In one paragraph
Article in Hypertension (Dallas, Tex. : 1979), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 3 pooled it
9.1field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
67 citing papers in PubMed, 3 syntheses or guidelines pooled it, 156 citations in OpenAlex.
- Identification of Risk Factors for Stroke in China: A Meta-Analysis of Prospective Cohort Studies.Frontiers in neurology · 2022Pooled it
- A systematic review of cardiovascular responses associated with ambient black carbon and fine particulate matter.Environment international · 2019Pooled it
- Associations of Exposure to Air Pollution with Insulin Resistance: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2018Pooled it
- Effect of Portable Air Filtration Systems on Personal Exposure to Fine Particulate Matter and Blood Pressure Among Residents in a Low-Income Senior Facility: A Randomized Clinical Trial.JAMA internal medicine · 2018Trial
- Ambient particulate matter pollution and stroke burden.Medical gas research · 2027Article
- Physical activity and cognitive performance: cross-sectional analysis of the Brazilian longitudinal study of adult health (ELSA-Brazil).Clinics (Sao Paulo, Brazil) · 2026Article
- Pollution-Induced Allergy Skews Metabolism Toward Obesity-A Conceptual Review.Current issues in molecular biology · 2026Review
- Effects of Outdoor and Household Air Pollution on Hand Grip Strength in a Longitudinal Study of Rural Beijing Adults.International journal of environmental research and public health · 2025Article
- Climate Vulnerability and Cardiovascular-Kidney-Metabolic Disease in the United States.Journal of the American Heart Association · 2025Article
- Space for improvement: ZIP codes should not determine cardiovascular longevity, a scoping review.Trends in cardiovascular medicine · 2025Article
- Association between annual concentration of air pollutants and incidence of metabolic syndrome among Korean adults: Korean Genome and Epidemiology Study (KoGES).Environmental health : a global access science source · 2025Article
- Ambient versus household PMFrontiers in public health · 2025Article
- Global burden, trends and health inequalities of stroke attributable to household air pollution, 1990-2021: a decomposition and prediction analysis.Frontiers in public health · 2025Article
- Ambient air pollution, covert cerebrovascular disease and cognition: results from the ISSYS study.European journal of neurology · 2024Article
- Effects of ambient air pollution on obesity and ectopic fat deposition: a protocol for a systematic review and meta-analysis.BMJ open · 2024Article
- Duration-sensitive association between air pollution exposure and changes in cardiometabolic biomarkers: Evidence from a predominantly African American cohort.Environmental research · 2024Article
- Environmental exposures and blood pressure in adolescents and adults in the T1D exchange clinic registry.Journal of diabetes and its complications · 2023Article
- Cigarette smoking and air pollution exposure and their effects on cardiovascular diseases.Frontiers in public health · 2023Review
- Overview of particulate air pollution and human health in China: Evidence, challenges, and opportunities.Innovation (Cambridge (Mass.)) · 2022Review
- Association of Short-Term Exposure to PMToxics · 2022Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 5 institutions in 3 countries.
Robert D BrookFrom the Division of Cardiovascular Medicine (R.D.B.) and Department of Biostatistics (Z.S., B.M.), University of Michigan, Ann Arbor; Air Quality Research Division, Environment Canada, Toronto, Ontario, Canada (J.R.B.); Department of Cardiology, Peking Union Medical College Hospital, Beijing, China (X.Z., Y.R., J.Y., L.S., R.L., H.L., S.Z., Q.F., Z.F.); Division of Cardiovascular Medicine, University of Maryland, Baltimore (X.R., S.R.); Department of Environmental Science and Engineering, Tsinghua University, Beijing, China (F.D.); Cardiovascular Institute and Fuwai Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China (D.G.); and Davis Heart and Lung Research Institute, Ohio State University College of Medicine, Columbus (Q.S.).
Zhichao SunFrom the Division of Cardiovascular Medicine (R.D.B.) and Department of Biostatistics (Z.S., B.M.), University of Michigan, Ann Arbor; Air Quality Research Division, Environment Canada, Toronto, Ontario, Canada (J.R.B.); Department of Cardiology, Peking Union Medical College Hospital, Beijing, China (X.Z., Y.R., J.Y., L.S., R.L., H.L., S.Z., Q.F., Z.F.); Division of Cardiovascular Medicine, University of Maryland, Baltimore (X.R., S.R.); Department of Environmental Science and Engineering, Tsinghua University, Beijing, China (F.D.); Cardiovascular Institute and Fuwai Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China (D.G.); and Davis Heart and Lung Research Institute, Ohio State University College of Medicine, Columbus (Q.S.).
Jeffrey R BrookFrom the Division of Cardiovascular Medicine (R.D.B.) and Department of Biostatistics (Z.S., B.M.), University of Michigan, Ann Arbor; Air Quality Research Division, Environment Canada, Toronto, Ontario, Canada (J.R.B.); Department of Cardiology, Peking Union Medical College Hospital, Beijing, China (X.Z., Y.R., J.Y., L.S., R.L., H.L., S.Z., Q.F., Z.F.); Division of Cardiovascular Medicine, University of Maryland, Baltimore (X.R., S.R.); Department of Environmental Science and Engineering, Tsinghua University, Beijing, China (F.D.); Cardiovascular Institute and Fuwai Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China (D.G.); and Davis Heart and Lung Research Institute, Ohio State University College of Medicine, Columbus (Q.S.).
Xiaoyi ZhaoFrom the Division of Cardiovascular Medicine (R.D.B.) and Department of Biostatistics (Z.S., B.M.), University of Michigan, Ann Arbor; Air Quality Research Division, Environment Canada, Toronto, Ontario, Canada (J.R.B.); Department of Cardiology, Peking Union Medical College Hospital, Beijing, China (X.Z., Y.R., J.Y., L.S., R.L., H.L., S.Z., Q.F., Z.F.); Division of Cardiovascular Medicine, University of Maryland, Baltimore (X.R., S.R.); Department of Environmental Science and Engineering, Tsinghua University, Beijing, China (F.D.); Cardiovascular Institute and Fuwai Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China (D.G.); and Davis Heart and Lung Research Institute, Ohio State University College of Medicine, Columbus (Q.S.).
Yanping RuanFrom the Division of Cardiovascular Medicine (R.D.B.) and Department of Biostatistics (Z.S., B.M.), University of Michigan, Ann Arbor; Air Quality Research Division, Environment Canada, Toronto, Ontario, Canada (J.R.B.); Department of Cardiology, Peking Union Medical College Hospital, Beijing, China (X.Z., Y.R., J.Y., L.S., R.L., H.L., S.Z., Q.F., Z.F.); Division of Cardiovascular Medicine, University of Maryland, Baltimore (X.R., S.R.); Department of Environmental Science and Engineering, Tsinghua University, Beijing, China (F.D.); Cardiovascular Institute and Fuwai Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China (D.G.); and Davis Heart and Lung Research Institute, Ohio State University College of Medicine, Columbus (Q.S.).
Jianhua YanFrom the Division of Cardiovascular Medicine (R.D.B.) and Department of Biostatistics (Z.S., B.M.), University of Michigan, Ann Arbor; Air Quality Research Division, Environment Canada, Toronto, Ontario, Canada (J.R.B.); Department of Cardiology, Peking Union Medical College Hospital, Beijing, China (X.Z., Y.R., J.Y., L.S., R.L., H.L., S.Z., Q.F., Z.F.); Division of Cardiovascular Medicine, University of Maryland, Baltimore (X.R., S.R.); Department of Environmental Science and Engineering, Tsinghua University, Beijing, China (F.D.); Cardiovascular Institute and Fuwai Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China (D.G.); and Davis Heart and Lung Research Institute, Ohio State University College of Medicine, Columbus (Q.S.).
Bhramar MukherjeeFrom the Division of Cardiovascular Medicine (R.D.B.) and Department of Biostatistics (Z.S., B.M.), University of Michigan, Ann Arbor; Air Quality Research Division, Environment Canada, Toronto, Ontario, Canada (J.R.B.); Department of Cardiology, Peking Union Medical College Hospital, Beijing, China (X.Z., Y.R., J.Y., L.S., R.L., H.L., S.Z., Q.F., Z.F.); Division of Cardiovascular Medicine, University of Maryland, Baltimore (X.R., S.R.); Department of Environmental Science and Engineering, Tsinghua University, Beijing, China (F.D.); Cardiovascular Institute and Fuwai Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China (D.G.); and Davis Heart and Lung Research Institute, Ohio State University College of Medicine, Columbus (Q.S.).
Xiaoquan RaoFrom the Division of Cardiovascular Medicine (R.D.B.) and Department of Biostatistics (Z.S., B.M.), University of Michigan, Ann Arbor; Air Quality Research Division, Environment Canada, Toronto, Ontario, Canada (J.R.B.); Department of Cardiology, Peking Union Medical College Hospital, Beijing, China (X.Z., Y.R., J.Y., L.S., R.L., H.L., S.Z., Q.F., Z.F.); Division of Cardiovascular Medicine, University of Maryland, Baltimore (X.R., S.R.); Department of Environmental Science and Engineering, Tsinghua University, Beijing, China (F.D.); Cardiovascular Institute and Fuwai Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China (D.G.); and Davis Heart and Lung Research Institute, Ohio State University College of Medicine, Columbus (Q.S.).
Fengkui DuanFrom the Division of Cardiovascular Medicine (R.D.B.) and Department of Biostatistics (Z.S., B.M.), University of Michigan, Ann Arbor; Air Quality Research Division, Environment Canada, Toronto, Ontario, Canada (J.R.B.); Department of Cardiology, Peking Union Medical College Hospital, Beijing, China (X.Z., Y.R., J.Y., L.S., R.L., H.L., S.Z., Q.F., Z.F.); Division of Cardiovascular Medicine, University of Maryland, Baltimore (X.R., S.R.); Department of Environmental Science and Engineering, Tsinghua University, Beijing, China (F.D.); Cardiovascular Institute and Fuwai Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China (D.G.); and Davis Heart and Lung Research Institute, Ohio State University College of Medicine, Columbus (Q.S.).
Lixian SunFrom the Division of Cardiovascular Medicine (R.D.B.) and Department of Biostatistics (Z.S., B.M.), University of Michigan, Ann Arbor; Air Quality Research Division, Environment Canada, Toronto, Ontario, Canada (J.R.B.); Department of Cardiology, Peking Union Medical College Hospital, Beijing, China (X.Z., Y.R., J.Y., L.S., R.L., H.L., S.Z., Q.F., Z.F.); Division of Cardiovascular Medicine, University of Maryland, Baltimore (X.R., S.R.); Department of Environmental Science and Engineering, Tsinghua University, Beijing, China (F.D.); Cardiovascular Institute and Fuwai Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China (D.G.); and Davis Heart and Lung Research Institute, Ohio State University College of Medicine, Columbus (Q.S.).
Ruijuan LiangFrom the Division of Cardiovascular Medicine (R.D.B.) and Department of Biostatistics (Z.S., B.M.), University of Michigan, Ann Arbor; Air Quality Research Division, Environment Canada, Toronto, Ontario, Canada (J.R.B.); Department of Cardiology, Peking Union Medical College Hospital, Beijing, China (X.Z., Y.R., J.Y., L.S., R.L., H.L., S.Z., Q.F., Z.F.); Division of Cardiovascular Medicine, University of Maryland, Baltimore (X.R., S.R.); Department of Environmental Science and Engineering, Tsinghua University, Beijing, China (F.D.); Cardiovascular Institute and Fuwai Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China (D.G.); and Davis Heart and Lung Research Institute, Ohio State University College of Medicine, Columbus (Q.S.).
Hui LianFrom the Division of Cardiovascular Medicine (R.D.B.) and Department of Biostatistics (Z.S., B.M.), University of Michigan, Ann Arbor; Air Quality Research Division, Environment Canada, Toronto, Ontario, Canada (J.R.B.); Department of Cardiology, Peking Union Medical College Hospital, Beijing, China (X.Z., Y.R., J.Y., L.S., R.L., H.L., S.Z., Q.F., Z.F.); Division of Cardiovascular Medicine, University of Maryland, Baltimore (X.R., S.R.); Department of Environmental Science and Engineering, Tsinghua University, Beijing, China (F.D.); Cardiovascular Institute and Fuwai Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China (D.G.); and Davis Heart and Lung Research Institute, Ohio State University College of Medicine, Columbus (Q.S.).
Shuyang ZhangFrom the Division of Cardiovascular Medicine (R.D.B.) and Department of Biostatistics (Z.S., B.M.), University of Michigan, Ann Arbor; Air Quality Research Division, Environment Canada, Toronto, Ontario, Canada (J.R.B.); Department of Cardiology, Peking Union Medical College Hospital, Beijing, China (X.Z., Y.R., J.Y., L.S., R.L., H.L., S.Z., Q.F., Z.F.); Division of Cardiovascular Medicine, University of Maryland, Baltimore (X.R., S.R.); Department of Environmental Science and Engineering, Tsinghua University, Beijing, China (F.D.); Cardiovascular Institute and Fuwai Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China (D.G.); and Davis Heart and Lung Research Institute, Ohio State University College of Medicine, Columbus (Q.S.).
Quan FangFrom the Division of Cardiovascular Medicine (R.D.B.) and Department of Biostatistics (Z.S., B.M.), University of Michigan, Ann Arbor; Air Quality Research Division, Environment Canada, Toronto, Ontario, Canada (J.R.B.); Department of Cardiology, Peking Union Medical College Hospital, Beijing, China (X.Z., Y.R., J.Y., L.S., R.L., H.L., S.Z., Q.F., Z.F.); Division of Cardiovascular Medicine, University of Maryland, Baltimore (X.R., S.R.); Department of Environmental Science and Engineering, Tsinghua University, Beijing, China (F.D.); Cardiovascular Institute and Fuwai Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China (D.G.); and Davis Heart and Lung Research Institute, Ohio State University College of Medicine, Columbus (Q.S.).
Dongfeng GuFrom the Division of Cardiovascular Medicine (R.D.B.) and Department of Biostatistics (Z.S., B.M.), University of Michigan, Ann Arbor; Air Quality Research Division, Environment Canada, Toronto, Ontario, Canada (J.R.B.); Department of Cardiology, Peking Union Medical College Hospital, Beijing, China (X.Z., Y.R., J.Y., L.S., R.L., H.L., S.Z., Q.F., Z.F.); Division of Cardiovascular Medicine, University of Maryland, Baltimore (X.R., S.R.); Department of Environmental Science and Engineering, Tsinghua University, Beijing, China (F.D.); Cardiovascular Institute and Fuwai Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China (D.G.); and Davis Heart and Lung Research Institute, Ohio State University College of Medicine, Columbus (Q.S.).
Qinghua SunFrom the Division of Cardiovascular Medicine (R.D.B.) and Department of Biostatistics (Z.S., B.M.), University of Michigan, Ann Arbor; Air Quality Research Division, Environment Canada, Toronto, Ontario, Canada (J.R.B.); Department of Cardiology, Peking Union Medical College Hospital, Beijing, China (X.Z., Y.R., J.Y., L.S., R.L., H.L., S.Z., Q.F., Z.F.); Division of Cardiovascular Medicine, University of Maryland, Baltimore (X.R., S.R.); Department of Environmental Science and Engineering, Tsinghua University, Beijing, China (F.D.); Cardiovascular Institute and Fuwai Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China (D.G.); and Davis Heart and Lung Research Institute, Ohio State University College of Medicine, Columbus (Q.S.).
Zhongjie FanFrom the Division of Cardiovascular Medicine (R.D.B.) and Department of Biostatistics (Z.S., B.M.), University of Michigan, Ann Arbor; Air Quality Research Division, Environment Canada, Toronto, Ontario, Canada (J.R.B.); Department of Cardiology, Peking Union Medical College Hospital, Beijing, China (X.Z., Y.R., J.Y., L.S., R.L., H.L., S.Z., Q.F., Z.F.); Division of Cardiovascular Medicine, University of Maryland, Baltimore (X.R., S.R.); Department of Environmental Science and Engineering, Tsinghua University, Beijing, China (F.D.); Cardiovascular Institute and Fuwai Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China (D.G.); and Davis Heart and Lung Research Institute, Ohio State University College of Medicine, Columbus (Q.S.).
Sanjay RajagopalanFrom the Division of Cardiovascular Medicine (R.D.B.) and Department of Biostatistics (Z.S., B.M.), University of Michigan, Ann Arbor; Air Quality Research Division, Environment Canada, Toronto, Ontario, Canada (J.R.B.); Department of Cardiology, Peking Union Medical College Hospital, Beijing, China (X.Z., Y.R., J.Y., L.S., R.L., H.L., S.Z., Q.F., Z.F.); Division of Cardiovascular Medicine, University of Maryland, Baltimore (X.R., S.R.); Department of Environmental Science and Engineering, Tsinghua University, Beijing, China (F.D.); Cardiovascular Institute and Fuwai Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China (D.G.); and Davis Heart and Lung Research Institute, Ohio State University College of Medicine, Columbus (Q.S.). srajagopalan@medicine.umaryland.edu.
University of Maryland, Baltimore · USPeking Union Medical College Hospital · CNTsinghua University · CNUniversity of Michigan–Ann Arbor · USChinese Academy of Medical Sciences & Peking Union Medical College · CN
Funding
Research BaseP30DK072488 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI MITCHELL, BRAXTON D, TAYLOR, SIMEON I. · 2005 to 2019
$17.3MAir Pollution and Hypertension: Vascular MechanismsR01ES015146 · NIEHS · UNIVERSITY OF MARYLAND BALTIMORE · PI RAJAGOPALAN, SANJAY · 2007 to 2018
$4.5MEnvironmental Triggers of Cardiometabolic DiseaseR01ES019616 · NIEHS · UNIVERSITY OF MARYLAND BALTIMORE · PI BROOK, ROBERT DANIEL, RAJAGOPALAN, SANJAY · 2011 to 2020
$3.0MDiabetes, Obesity, and Metabolic ComplicationsT32DK098107 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI TAYLOR, SIMEON I. · 2015 to 2025
$2.4MDiet-Environment Interactions in InflammationR01ES017290 · NIEHS · UNIVERSITY OF MARYLAND BALTIMORE · PI RAJAGOPALAN, SANJAY · 2010 to 2014
$1.8MNIDDK NIH HHS P30 DK072488NIDDK NIH HHS T32 DK098107NIEHS NIH HHS R01 ES015146NIEHS NIH HHS R01ES015146NIEHS NIH HHS R01 ES017290NIEHS NIH HHS R01ES017290NIEHS NIH HHS R01 ES019616NIEHS NIH HHS R01ES019616
Abstract
Mounting evidence supports that fine particulate matter adversely affects cardiometabolic diseases particularly in susceptible individuals; however, health effects induced by the extreme concentrations within megacities in Asia are not well described. We enrolled 65 nonsmoking adults with metabolic syndrome and insulin resistance in the Beijing metropolitan area into a panel study of 4 repeated visits across 4 seasons since 2012. Daily ambient fine particulate matter and personal black carbon levels ranged from 9.0 to 552.5 µg/m(3) and 0.2 to 24.5 µg/m(3), respectively, with extreme levels observed during January 2013. Cumulative fine particulate matter exposure windows across the prior 1 to 7 days were significantly associated with systolic blood pressure elevations ranging from 2.0 (95% confidence interval, 0.3-3.7) to 2.7 (0.6-4.8) mm Hg per SD increase (67.2 µg/m(3)), whereas cumulative black carbon exposure during the previous 2 to 5 days were significantly associated with ranges in elevations in diastolic blood pressure from 1.3 (0.0-2.5) to 1.7 (0.3-3.2) mm Hg per SD increase (3.6 µg/m(3)). Both black carbon and fine particulate matter were significantly associated with worsening insulin resistance (0.18 [0.01-0.36] and 0.22 [0.04-0.39] unit increase per SD increase of personal-level black carbon and 0.18 [0.02-0.34] and 0.22 [0.08-0.36] unit increase per SD increase of ambient fine particulate matter on lag days 4 and 5). These results provide important global public health warnings that air pollution may pose a risk to cardiometabolic health even at the extremely high concentrations faced by billions of people in the developing world today.
Indexed as
Air PollutantsAir PollutionBeijingBlood PressureCardiovascular DiseasesFemaleFollow-Up StudiesHumansIncidenceInsulinInsulin ResistanceMaleMiddle AgedParticulate MatterProspective StudiesAir PollutantsInsulinParticulate Matterair pollutiondiabetes mellitushypertensioninsulin resistancemetabolism
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