ArticleAnnals of intensive care2015
Personalizing blood pressure management in septic shock.
Article in Annals of intensive care, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
61 citing papers in PubMed, 2 syntheses or guidelines pooled it, 132 citations in OpenAlex.
- Risk factors for chronic kidney disease and septic shock with hypertension in adults and children.Frontiers in nephrology · 2025Pooled it
- Guidelines for hospital nephrology assistance from the Brazilian Society of Nephrology (BSN).Jornal brasileiro de nefrologiaGuideline
- Efficacy of targeting high mean arterial pressure for older patients with septic shock (OPTPRESS): a multicentre, pragmatic, open-label, randomised controlled trial.Intensive care medicine · 2025Trial
- Effects of exercise training on calf muscle oxygen extraction and blood flow in patients with peripheral artery disease.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Trial
- Energy, flow and pressure in the cardiovascular system: a narrative review of how the circulation works.Anaesthesia · 2026Review
- Twenty-five years of septic shock hemodynamic resuscitation trials: a conceptual perspective.Critical care (London, England) · 2026Review
- Intravenous megadose sodium ascorbate normalises elevations in intracranial pressure and restores pressor responsiveness to norepinephrine in ovine Gram-negative sepsis.Scientific reports · 2026Article
- Targeting and monitoring mean arterial pressure in critical illness: A mixed-methods service evaluation.Journal of the Intensive Care Society · 2026Article
- Arteriolar Collapse and Haemodynamic Incoherence in Shock: Rethinking Critical Closing Pressure.Journal of personalized medicine · 2026Review
- Advancing post-stroke blood pressure management: an individualized BP strategy for function optimization.Annals of medicine · 2025Review
- Precision Profiling of Disease Progression in Murine Models of Sepsis and Septic Shock.International journal of molecular sciences · 2025Article
- Association of Dynamic Arterial Elastance With Fluid Responsiveness in Critically Ill Children.Critical care explorations · 2025Observational
- Non-linear associations between renal perfusion pressure indexes and AKI incidence and recovery rate.European journal of medical research · 2025Article
- Hemodynamic effects of adjunct arginine vasopressin to norepinephrine in septic shock: insights from a prospective multicenter registry study.Annals of intensive care · 2025Article
- Continuous Measurement of Radial Free Forearm Flap Tissue Perfusion for Flap Monitoring After Microvascular Head and Neck Reconstruction-Systemic Blood Pressure as a Potential Confounder in the Early Postoperative Period.Journal of clinical medicine · 2025Article
- A retrospective cohort analysis comparing the effectiveness and safety of perioperative angiotensin II to adrenergic vasopressors as a first-line vasopressor in kidney transplant recipients.Journal of anesthesia, analgesia and critical care · 2024Article
- Capillary Refill Time as a Part of Routine Physical Examination in Critically Ill Patients Undergoing Vasoactive Therapy: A Prospective Study.Journal of clinical medicine · 2024Article
- Complex Pathophysiology of Acute Kidney Injury (AKI) in Aging: Epigenetic Regulation, Matrix Remodeling, and the Healing Effects of HBiomolecules · 2024Review
- Angiotensin II as a Vasopressor for Perioperative Hypotension in Solid Organ Transplant.Biomedicines · 2024Review
- Microvascular Autoregulation in Skeletal Muscle Using Near-Infrared Spectroscopy and Derivation of Optimal Mean Arterial Pressure in the ICU: Pilot Study and Comparison With Cerebral Near-Infrared Spectroscopy.Critical care explorations · 2024Observational
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This review examines the available evidence for targeting a specific mean arterial pressure (MAP) in sepsis resuscitation. The clinical data suggest that targeting an MAP of 65-70 mmHg in patients with septic shock who do not have chronic hypertension is a reasonable first approximation. Whereas in patients with chronic hypertension, targeting a higher MAP of 80-85 mmHg minimizes renal injury, but it comes with increased risk of arrhythmias. Importantly, MAP alone should not be used as a surrogate of organ perfusion pressure, especially under conditions in which intracranial, intra-abdominal or tissue pressures may be elevated. Organ-specific perfusion pressure targets include 50-70 mmHg for the brain based on trauma brain injury as a surrogate for sepsis, 65 mmHg for renal perfusion and >50 mmHg for hepato-splanchnic flow. Even at the same MAP, organs and regions within organs may have different perfusion pressure and pressure-flow relationships. Thus, once this initial MAP target is achieved, MAP should be titrated up or down based on the measures of organ function and tissue perfusion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.