Evidence map›Paper›PMID 26573616›Full record

ArticleBMC cardiovascular disorders2015

Low-dose CT coronary angiography for assessment of coronary artery disease in patients with type 2 diabetes--a cross-sectional study.

Geir Reinvik Ulimoen, Anne Pernille Ofstad, Knut Endresen, Lars Gullestad, Odd Erik Johansen, Arne Borthne

Registry-linked trialOpen access · goldAbstract readComparative StudyEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cardiovascular disorders, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00133718 (Asker and Baerum Cardiovascular Diabetes Study), which is not on this map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00133718 phase4completednot on this map

Asker and Baerum Cardiovascular Diabetes Study

TypeinterventionalSponsorAsker & Baerum HospitalRan2002 to 2012Enrolled120ConditionsType 2 Diabetes MellitusArmsCombined lifestyle intervention and optimisation of pharmacological treatment
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Article
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  4. Review
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Geir Reinvik UlimoenDepartment of Radiology, Akershus University Hospital, PB 1000, 1478, Lorenskog, Norway. geir.ulimoen@online.no.
Anne Pernille OfstadDepartment of Medical Research, Bærum Hospital, Vestre Viken Hospital Trust, 3004, Drammen, Norway. annepernille@hotmail.com.
Knut EndresenDepartment of Cardiology, Oslo University Hospital, Rikshospitalet, 0372, Oslo, Norway. knuend@ous-hf.no.
Lars GullestadDepartment of Cardiology, Oslo University Hospital, Rikshospitalet, 0372, Oslo, Norway. lars.gullestad@medisin.uio.no.
Odd Erik JohansenDepartment of Medical Research, Bærum Hospital, Vestre Viken Hospital Trust, 3004, Drammen, Norway. odd_erik.johansen@boehringer-ingelheim.com.
Arne BorthneDepartment of Radiology, Akershus University Hospital, PB 1000, 1478, Lorenskog, Norway. Arne.Borthne@ahus.no.
Oslo University Hospital · NOVestre Viken Hospital Trust · NOAkershus University Hospital · NOUniversity of Oslo · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSilent coronary artery disease (CAD) is prevalent in type 2 diabetes mellitus (T2DM). Although coronary computed tomography angiography (CCTA) over recent years has emerged a useful tool for assessing and diagnosing CAD it's role and applicability for patients with T2DM is still unclarified, in particular in asymptomatic patients. We aimed to assess the role of CCTA in detecting and characterizing CAD in patients with T2DM without cardiac symptoms when compared to gold standard invasive coronary angiography (ICA).

methodsThis was a cross-sectional analysis of patients with T2DM without symptomatic CAD enrolled in the Asker and Baerum Cardiovascular Diabetes Study who, following clinical examination and laboratory assessment, underwent subsequently CCTA and ICA.

resultsIn total 48 Caucasian patients with T2DM (36 men, age 64.0 ± 7.3 years, diabetes duration 14.6 ± 6.4 years, HbA1c 7.4 ± 1.1 %, BMI 29.6 ± 4.3 kg/m(2)) consented to, and underwent, both procedures (CCTA and ICA). The population was at intermediate cardiovascular risk (mean coronary artery calcium score 269, 75 % treated with antihypertensive therapy). ICA identified a prevalence of silent CAD at 17 % whereas CCTA 35 %. CCTA had a high sensitivity (100 %) and a high negative predictive value (100 %) for detection of patients with CAD when compared to ICA, but the positive predictive value was low (47 %).

conclusionsLow-dose CCTA is a reliable method for detection and exclusion of significant CAD in T2DM and thus may be a useful tool for the clinicians. However, a low positive predictive value may limit its usefulness as a screening tool for all CAD asymptomatic patients with T2DM. Further studies should assess the applicability for risk assessment beyond the evaluation of the vascular bed.

Indexed as

Multidetector Computed TomographyRadiation DosageAdultAgedAsymptomatic DiseasesCoronary AngiographyCoronary Artery DiseaseCross-Sectional StudiesDiabetes Mellitus, Type 2Diabetic AngiopathiesFemaleHumansMaleMiddle AgedNorwayPredictive Value of Tests

Identifiers

PMID26573616
PMCPMC4647633
OpenAlexW2187841208

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.