Evidence map›Paper›PMID 26573424›Full record

ReviewNature reviews. Clinical oncology2016

Cachexia in patients with oesophageal cancer.

Poorna Anandavadivelan, Pernilla Lagergren

2 registry-linked trialsAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Clinical oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 137 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
137citing papers in PubMed, 5 pooled it
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03654105 phase2active not recruitingnot on this mapstarted 2019, after this paper: background citation

Multifactorial Intervention of Primary Prevention in High Risk Subjects: a Randomized Trial

TypeinterventionalSponsorFondazione IRCCS Istituto Nazionale dei Tumori, MilanoRan2019 to 2026Enrolled2,000ConditionsInflammation, Smoking Cessation, Diet Modification, Physical ActivityArmsCytisine, Acetylsalicylic acid, Diet Modification and Physical Activity Increase, early lung cancer detection, spirometry with CO test
NCT05035602 completednot on this mapstarted 2022, after this paper: background citation

Google Location History (GLH) as a Health Tool to Assess Physical Activity Profiles and Patterns Following Oesophagectomy and/or Gastrectomy

TypeobservationalSponsorImperial College LondonRan2022 to 2023Enrolled3ConditionsOesophageal Cancer, Gastric Cancer, Survivorship, Quality of LifeArmsPhysical activity assessment
3 · Its place in the literature

Who cites it

137 citing papers in PubMed, 5 syntheses or guidelines pooled it, 266 citations in OpenAlex.

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  14. Utility and outcomes of routine jejunostomy placement following oesophagectomy.Annals of the Royal College of Surgeons of England · 2026
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77 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Poorna AnandavadivelanMolecular Medicine and Surgery, Karolinska Institutet, Norra Stationsgatan 67, Level 2, Stockholm 17176, Sweden.
Pernilla LagergrenMolecular Medicine and Surgery, Karolinska Institutet, Norra Stationsgatan 67, Level 2, Stockholm 17176, Sweden.
Karolinska Institutet · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oesophageal cancer is a debilitating disease with a poor prognosis, and weight loss owing to malnutrition prevails in the majority of patients. Cachexia, a multifactorial syndrome characterized by the loss of fat and skeletal muscle mass and systemic inflammation arising from complex host-tumour interactions is a major contributor to malnutrition, which is a determinant of tolerance to treatment and survival. In patients with oesophageal cancer, cachexia is further compounded by eating difficulties owing to the stage and location of the tumour, and the effects of neoadjuvant therapy. Treatment with curative intent involves exceptionally extensive and invasive surgery, and the subsequent anatomical changes often lead to eating difficulties and severe postoperative malnutrition. Thus, screening for cachexia by means of percentage weight loss and BMI during the cancer trajectory and survivorship periods is imperative. Additionally, markers of inflammation (such as C-reactive protein), dysphagia and appetite loss should be assessed at diagnosis. Routine assessments of body composition are also necessary in patients with oesophageal cancer to enable assessment of skeletal muscle loss, which might be masked by sarcopenic obesity in these patients. A need exists for clinical trials examining the effectiveness of therapeutic and physical-activity-based interventions in mitigating muscle loss and counteracting cachexia in these patients.

Indexed as

Nutritional StatusBody CompositionCachexiaEsophageal NeoplasmsHumansNutrition AssessmentPredictive Value of TestsQuality of LifeRisk AssessmentRisk FactorsTreatment OutcomeWeight Loss

Identifiers

PMID26573424
OpenAlexW2263456779

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.