ArticleEJNMMI research2015
Modeling [(18)F]-FDG lymphoid tissue kinetics to characterize nonhuman primate immune response to Middle East respiratory syndrome-coronavirus aerosol challenge.
Article in EJNMMI research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Coronavirus Disease 2019 (COVID-19) in Molecular Imaging: A Systematic Review of Incidental Detection of SARS-CoV-2 Pneumonia on PET Studies.Seminars in nuclear medicine · 2021Pooled it
- COVID-19 pneumonia: relationship between inflammation assessed by whole-body FDG PET/CT and short-term clinical outcome.European journal of nuclear medicine and molecular imaging · 2021Trial
- Validation of Lung [Molecular imaging and biology · 2025Article
- Advances and Challenges in Molecular Imaging of Viral Infections.The Journal of infectious diseases · 2023Review
- [Diagnostics (Basel, Switzerland) · 2022Article
- The imaging quantification of multiple organs by dynamicInternational journal of medical sciences · 2022Article
- Positron emission tomography in the COVID-19 pandemic era.European journal of nuclear medicine and molecular imaging · 2021Review
- COVID-19 pneumonia: A review of typical radiological characteristics.World journal of radiology · 2021Review
- Long COVID hallmarks on [18F]FDG-PET/CT: a case-control study.European journal of nuclear medicine and molecular imaging · 2021Article
- Inflammatory response in lungs and extrapulmonary sites detected by [European journal of nuclear medicine and molecular imaging · 2021Article
- Imaging of COVID-19: CT, MRI, and PET.Seminars in nuclear medicine · 2021Review
- Incidental Detections Suggestive of COVID-19 in Asymptomatic Patients Undergoing 68Ga-DOTATATE and 68Ga-PSMA-11 PET-CT Scan for Oncological Indications.Nuklearmedizin. Nuclear medicine · 2021Article
- Assessment of extra-parenchymal lung involvement in asymptomatic cancer patients with COVID-19 pneumonia detected onEuropean journal of nuclear medicine and molecular imaging · 2021Article
- State of the art ofClinical and translational imaging · 2021Review
- Global research trends in COVID-19 with MRI and PET/CT: a scoping review with bibliometric and network analyses.Clinical and translational imaging · 2021Article
- Peptide-Conjugated Phosphorodiamidate Morpholino Oligomers for In Situ Live-Cell Molecular Imaging of Dengue Virus Replication.International journal of molecular sciences · 2020Article
- Small Particle Aerosol Exposure of African Green Monkeys to MERS-CoV as a Model for Highly Pathogenic Coronavirus Infection.Emerging infectious diseases · 2020Article
- Clinical features and radiological manifestations of COVID-19 disease.World journal of radiology · 2020Review
- FDG PET/CT evaluation of a patient recovering from COVID-19.European journal of nuclear medicine and molecular imaging · 2020Article
- Imaging Diagnostics and Pathology in SARS-CoV-2-Related Diseases.International journal of molecular sciences · 2020Review
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe pathogenesis and immune response to Middle East respiratory syndrome (MERS) caused by a recently discovered coronavirus, MERS-CoV, have not been fully characterized because a suitable animal model is currently not available. (18)F-Fluorodeoxyglucose ([(18)F]-FDG)-positron emission tomography/computed tomography (PET/CT) as a longitudinal noninvasive approach can be beneficial in providing biomarkers for host immune response. [(18)F]-FDG uptake is increased in activated immune cells in response to virus entry and can be localized by PET imaging. We used [(18)F]-FDG-PET/CT to investigate the host response developing in nonhuman primates after MERS-CoV exposure and applied kinetic modeling to monitor the influx rate constant (K i ) in responsive lymphoid tissue.
methodsMultiple [(18)F]-FDG-PET and CT images were acquired on a PET/CT clinical scanner modified to operate in a biosafety level 4 environment prior to and up to 29 days after MERS-CoV aerosol exposure. Time activity curves of various lymphoid tissues were reconstructed to follow the [(18)F]-FDG uptake for approximately 60 min (3,600 s). Image-derived input function was used to calculate K i for lymphoid tissues by Patlak plot.
resultsTwo-way repeated measures analysis of variance revealed alterations in K i that was associated with the time point (p < 0.001) after virus exposure and the location of lymphoid tissue (p = 0.0004). As revealed by a statistically significant interaction (p < 0.0001) between these two factors, the pattern of K i changes over time differed between three locations but not between subjects. A distinguished pattern of statistically significant elevation in K i was observed in mediastinal lymph nodes (LNs) that correlated to K i changes in axillary LNs. Changes in LNs K i were concurrent with elevations of monocytes in peripheral blood.
conclusions[(18)F]-FDG-PET is able to detect subtle changes in host immune response to contain a subclinical virus infection. Full quantitative analysis is the preferred approach rather than semiquantitative analysis using standardized uptake value for detection of the immune response to the virus.
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