ArticleGlobal journal of health science2015
Association of Chlamydia pneumoniae Infection With Atherosclerotic Plaque Formation.
Article in Global journal of health science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Antibiotics for secondary prevention of coronary heart disease.The Cochrane database of systematic reviews · 2021Pooled it
- Chlamydia Pneumoniae Pericarditis Complicated with Guillain-Barré Syndrome.Life (Basel, Switzerland) · 2025Article
- Oxidative Stress and Inflammation in SARS-CoV-2- andBiomedicines · 2021Review
- Reliable and Sensitive Nested PCR for the Detection ofMicroorganisms · 2021Article
- Genital Chlamydia infection in hyperlipidemic mouse models exacerbates atherosclerosis.Atherosclerosis · 2019Article
- Bacterial infections are associated with cardiovascular disease in Iran: a meta-analysis.Archives of medical science : AMS · 2019Article
- The association of mannose binding lectin genotype and immune response to Chlamydia pneumoniae: The Strong Heart Study.PloS one · 2019Article
- Detection ofIranian journal of public health · 2018Article
- The multifaceted link between inflammation and human diseases.Journal of cellular physiology · 2018Review
- Chlamydia trachomatis Seroprevalence and Ultrasound-Diagnosed Uterine Fibroids in a Large Population of Young African-American Women.American journal of epidemiology · 2018Article
- Mannose-binding lectin 2 (Mbl2) gene polymorphisms are related to protein plasma levels, but not to heart disease and infection by Chlamydia.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2016Article
- Increased alpha-defensin expression is associated with risk of coronary heart disease: a feasible predictive inflammatory biomarker of coronary heart disease in hyperlipidemia patients.Lipids in health and disease · 2016Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Atherosclerosis is a complex multifactorial disorder. Studies show that infectious microbial agents may play an important role in the development of atherosclerosis; however, these findings are conflicting. This study investigated the presence of Chlamydia pneumoniae DNA in atherosclerotic plaques of patients suffering from coronary artery disease. In a cross-sectional study, 85 patients (43 females and 42 males with mean age of 61±9.5, range 42-82 years) referred for coronary artery bypass grafting (CABG) and thoracic biopsy as the control groups were enrolled for this study. Standard questionnaires, including demographic and clinical evaluation were administered. Obtained specimens were processed and then nested polymerase chain reaction with primers for Pst1 fragment was carried out to detect Chlamydia pneumoniae DNA. Statistical analysis was done using the SPSS software. Of note, in 25 out of the 85 patients (29.4%), C. pneumoniae was detected within atherosclerotic plaques, whereas, 5 out of the 85 thoracic biopsy (5.9%) were positive for the presence of the mentioned bacteria in internal thoracic artery. There was a statistically significant association between atherosclerotic plaque (study group) and thoracic biopsy (control group) in terms of C. pneumoniae positivity (P= 0.0001). The findings of this study support the hypothesis that C. pneumoniae is associated with atherosclerosis.
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