Evidence map›Paper›PMID 26572896›Full record

ArticlePsychopharmacology2016

Acute effects of cocaine and cannabis on reversal learning as a function of COMT and DRD2 genotype.

Desirée B Spronk, Marieke E Van der Schaaf, Roshan Cools, Ellen R A De Bruijn, Barbara Franke, Janelle H P van Wel, Johannes G Ramaekers, Robbert J Verkes

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychopharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
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  3. PGx-BasedCurrent neuropharmacology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Desirée B SpronkDepartment of Psychiatry, Radboud university medical center, Nijmegen, The Netherlands. desireespronk@gmail.com.
Marieke E Van der SchaafDonders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands.
Roshan CoolsDepartment of Psychiatry, Radboud university medical center, Nijmegen, The Netherlands.
Ellen R A De BruijnDepartment of Clinical Psychology, Leiden Institute for Brain and Cognition, Leiden University, Leiden, The Netherlands.
Barbara FrankeDepartment of Psychiatry, Radboud university medical center, Nijmegen, The Netherlands.
Janelle H P van WelDepartment of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands.
Johannes G RamaekersDepartment of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands.
Robbert J VerkesDepartment of Psychiatry, Radboud university medical center, Nijmegen, The Netherlands.
Radboud University Medical Center · NLMaastricht University · NLRadboud University Nijmegen · NLLeiden University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

rationaleLong-term cannabis and cocaine use has been associated with impairments in reversal learning. However, how acute cannabis and cocaine administration affect reversal learning in humans is not known.

objectiveIn this study, we aimed to establish the acute effects of administration of cannabis and cocaine on valence-dependent reversal learning as a function of DRD2 Taq1A (rs1800497) and COMT Val108/158Met (rs4680) genotype.

methodsA double-blind placebo-controlled randomized 3-way crossover design was used. Sixty-one regular poly-drug users completed a deterministic reversal learning task under the influence of cocaine, cannabis, and placebo that enabled assessment of both reward- and punishment-based reversal learning.

resultsProportion correct on the reversal learning task was increased by cocaine, but decreased by cannabis. Effects of cocaine depended on the DRD2 genotype, as increases in proportion correct were seen only in the A1 carriers, and not in the A2/A2 homozygotes. COMT genotype did not modulate drug-induced effects on reversal learning.

conclusionsThese data indicate that acute administration of cannabis and cocaine has opposite effects on reversal learning. The effects of cocaine, but not cannabis, depend on interindividual genetic differences in the dopamine D2 receptor gene.

Indexed as

CannabisAdolescentAdultAttentionCatechol O-MethyltransferaseCocaineDouble-Blind MethodFemaleGenetic VariationHumansMaleNeuropsychological TestsPunishmentReceptors, Dopamine D2Reversal LearningRewardCatechol O-MethyltransferaseCocaineCOMT protein, humanDRD2 protein, humanReceptors, Dopamine D2CannabisCocaineCOMT Val108/158MetDRD2 Taq1AHumanIndividual differencesPolymorphismReversal learningTHC

Identifiers

PMID26572896
PMCPMC4700084
OpenAlexW2197408289

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.