ArticlePediatric nephrology (Berlin, Germany)2016
Smaller circuits for smaller patients: improving renal support therapy with Aquadex™.
Article in Pediatric nephrology (Berlin, Germany), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 105 citations in OpenAlex.
- Neonatal continuous kidney replacement therapy.Pediatric nephrology (Berlin, Germany) · 2026Review
- Dialysis modality and mortality of the Contemporary Infant and Neonatal Dialysis (COINED) Cohort: a Pediatric Nephrology Research Consortium (PNRC) study.Pediatric nephrology (Berlin, Germany) · 2026Article
- Renal replacement therapy in the neonatal intensive care unit: balancing neonatal expertise with practicality - Proceedings from the First International Neonatal Nephrology Symposium.Pediatric research · 2026Article
- Medical device regulation and dialysis practice-impact on patients, doctors and manufacturers.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2026Review
- Continuous Kidney Replacement Therapy in Pediatric Intensive Care: A Practical Guide for Clinicians.Indian pediatrics · 2026Review
- Epoprostenol as an alternative anticoagulant for pediatric aquadex therapy: a safe and feasible option.Frontiers in pediatrics · 2026Article
- In vitro measurements of ultrafiltration precision in hemofiltration and hemodialysis devices used in infants, Part 2: Comparison of PrisMax and CARPEDIEM with previous data on NIDUS, Prismaflex and Aquarius.Pediatric nephrology (Berlin, Germany) · 2025Article
- Renal replacement therapy in an intensive care unit: guidelines from the SRLF-GFRUP consensus conference.Annals of intensive care · 2025Review
- Making a start - WE-ROCK registry and the aim of global equity in pediatric CKRT.Pediatric nephrology (Berlin, Germany) · 2025Article
- Response to "The Urgent Need for Hemodialysis and Ultrafiltration Devices Specifically Designed for Neonates".Kidney international reports · 2025Article
- The Brophy Kit: A Manual Hemodialysis Device for Neonates.Kidney international reports · 2025Article
- AEIOU strategy for continuous renal replacement therapy in infants <10 kg: a practical and educational framework.Frontiers in pediatrics · 2025Review
- Severe Fetal CAKUT (Congenital Anomalies of the Kidneys and Urinary Tract), Prenatal Consultations, and Initiation of Neonatal Dialysis.American journal of perinatology · 2024Article
- Programs and processes for advancing pediatric acute kidney support therapy in hospitalized and critically ill children: a report from the 26th Acute Disease Quality Initiative (ADQI) consensus conference.Pediatric nephrology (Berlin, Germany) · 2024Article
- Validation of a low-cost continuous renal replacement therapy dialysate fluid controller for experimental purposes.Intensive care medicine experimental · 2024Article
- Using aquapheresis with continuous hematocrit monitoring to guide ultrafiltration.Pediatric nephrology (Berlin, Germany) · 2024Article
- New perspectives in pediatric dialysis technologies: the case for neonates and infants with acute kidney injury.Pediatric nephrology (Berlin, Germany) · 2024Article
- A simplified protocol of regional citrate anticoagulation with phosphate-containing solutions in infants and children treated with continuous kidney replacement therapy.Pediatric nephrology (Berlin, Germany) · 2023Article
- Safety and efficacy of continuous renal replacement therapy for children less than 10 kg using standard adult machines.European journal of pediatrics · 2023Article
- CARPEDIEM® for continuous kidney replacement therapy in neonates and small infants: a French multicenter retrospective study.Pediatric nephrology (Berlin, Germany) · 2023Article
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundProviding renal support for small children is very challenging using the machinery currently available in the United States. As the extracorporeal volume (ECV) relative to blood volume increases and the state of critical illness worsens, the chance for instability during continuous renal replacement therapy (CRRT) initiation also increases. CRRT machines with smaller ECV could reduce the risks and improve outcomes.
methodsWe present a case series of small children (n = 12) who received continuous venovenous hemofiltration (CVVH) via an Aquadex™ machine (ECV = 33 ml) with 30 ml/kg/h of prereplacement fluids at Children's of Alabama between December 2013 and April 2015. We assessed in vitro fluid precision using the adapted continuous veno-venous hemofiltration (CVVH) system.
resultsWe used 101 circuits over 261 days to provide CVVH for 12 children (median age 30 days; median weight 3.4 kg). Median CVVH duration was 14.5 days [interquartile range (IQR) = 10; 22.8 days]. Most circuits were routinely changed after 72 h. Five of 101 (5 %) initiations were associated with mild transient change in vital signs. Complications were infrequent (three transient cases of hypothermia, three puncture-site bleedings, one systemic bleed, and one right atrial thrombus). Most patients (7/12, 58 %) were discharged from the intensive care unit; six of them (50 %) were discharged home.
conclusionsCRRT machines with low ECV can enable clinicians to provide adequate, timely, safe, and efficient renal support to small, critically ill infants.
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