Evidence map›Paper›PMID 26572795›Full record

ArticleCirculation2015

The Utility of Therapeutic Hypothermia for Post-Cardiac Arrest Syndrome Patients With an Initial Nonshockable Rhythm.

Sarah M Perman, Anne V Grossestreuer, Douglas J Wiebe, Brendan G Carr, Benjamin S Abella, David F Gaieski

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 72 citations in OpenAlex.

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  10. [Targeted temperature management for cardiac arrest with nonshockable rhythm].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2020
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Sarah M PermanFrom the University of Colorado School of Medicine, Department of Emergency Medicine, Aurora (S.M.P.); University of Pennsylvania, Perelman School of Medicine, Department of Biostatistics and Epidemiology, Philadelphia (A.V.G., D.J.W.); University of Pennsylvania, Center for Resuscitation Science, Philadelphia (A.V.G., B.S.A.); University of Pennsylvania, Perelman School of Medicine, Department of Emergency Medicine, Philadelphia (A.V.G., D.J.W., B.S.A.); and Thomas Jefferson University, Sidney Kimmel School of Medicine, Department of Emergency Medicine, Philadelphia, PA (B.G.C., D.F.G.). sarah.perman@ucdenver.edu.
Anne V GrossestreuerFrom the University of Colorado School of Medicine, Department of Emergency Medicine, Aurora (S.M.P.); University of Pennsylvania, Perelman School of Medicine, Department of Biostatistics and Epidemiology, Philadelphia (A.V.G., D.J.W.); University of Pennsylvania, Center for Resuscitation Science, Philadelphia (A.V.G., B.S.A.); University of Pennsylvania, Perelman School of Medicine, Department of Emergency Medicine, Philadelphia (A.V.G., D.J.W., B.S.A.); and Thomas Jefferson University, Sidney Kimmel School of Medicine, Department of Emergency Medicine, Philadelphia, PA (B.G.C., D.F.G.).
Douglas J WiebeFrom the University of Colorado School of Medicine, Department of Emergency Medicine, Aurora (S.M.P.); University of Pennsylvania, Perelman School of Medicine, Department of Biostatistics and Epidemiology, Philadelphia (A.V.G., D.J.W.); University of Pennsylvania, Center for Resuscitation Science, Philadelphia (A.V.G., B.S.A.); University of Pennsylvania, Perelman School of Medicine, Department of Emergency Medicine, Philadelphia (A.V.G., D.J.W., B.S.A.); and Thomas Jefferson University, Sidney Kimmel School of Medicine, Department of Emergency Medicine, Philadelphia, PA (B.G.C., D.F.G.).
Brendan G CarrFrom the University of Colorado School of Medicine, Department of Emergency Medicine, Aurora (S.M.P.); University of Pennsylvania, Perelman School of Medicine, Department of Biostatistics and Epidemiology, Philadelphia (A.V.G., D.J.W.); University of Pennsylvania, Center for Resuscitation Science, Philadelphia (A.V.G., B.S.A.); University of Pennsylvania, Perelman School of Medicine, Department of Emergency Medicine, Philadelphia (A.V.G., D.J.W., B.S.A.); and Thomas Jefferson University, Sidney Kimmel School of Medicine, Department of Emergency Medicine, Philadelphia, PA (B.G.C., D.F.G.).
Benjamin S AbellaFrom the University of Colorado School of Medicine, Department of Emergency Medicine, Aurora (S.M.P.); University of Pennsylvania, Perelman School of Medicine, Department of Biostatistics and Epidemiology, Philadelphia (A.V.G., D.J.W.); University of Pennsylvania, Center for Resuscitation Science, Philadelphia (A.V.G., B.S.A.); University of Pennsylvania, Perelman School of Medicine, Department of Emergency Medicine, Philadelphia (A.V.G., D.J.W., B.S.A.); and Thomas Jefferson University, Sidney Kimmel School of Medicine, Department of Emergency Medicine, Philadelphia, PA (B.G.C., D.F.G.).
David F GaieskiFrom the University of Colorado School of Medicine, Department of Emergency Medicine, Aurora (S.M.P.); University of Pennsylvania, Perelman School of Medicine, Department of Biostatistics and Epidemiology, Philadelphia (A.V.G., D.J.W.); University of Pennsylvania, Center for Resuscitation Science, Philadelphia (A.V.G., B.S.A.); University of Pennsylvania, Perelman School of Medicine, Department of Emergency Medicine, Philadelphia (A.V.G., D.J.W., B.S.A.); and Thomas Jefferson University, Sidney Kimmel School of Medicine, Department of Emergency Medicine, Philadelphia, PA (B.G.C., D.F.G.).
University of Colorado Denver · USUniversity of Pennsylvania · US

Funding

Neurologic Clinical Epidemiology Training ProgramT32NS061779 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI Andrea Lauren Christman Schneider, Allison Willis · 2008 to 2026
$4.6M
NINDS NIH HHS 5T32NS061779-05NINDS NIH HHS T32 NS061779
6 · The paper itself

Abstract

backgroundTherapeutic hypothermia (TH) attenuates reperfusion injury in comatose survivors of cardiac arrest. The utility of TH in patients with nonshockable initial rhythms has not been widely accepted. We sought to determine whether TH improved neurological outcome and survival in postarrest patients with nonshockable rhythms. METHODS AND

resultsWe identified 519 patients after in- and out-of-hospital cardiac arrest with nonshockable initial rhythms from the Penn Alliance for Therapeutic Hypothermia (PATH) registry between 2000 and 2013. Propensity score matching was used. Patient and arrest characteristics used to estimate the propensity to receive TH were age, sex, location of arrest, witnessed arrest, and duration of arrest. To determine the association between TH and outcomes, we created 2 multivariable logistic models controlling for confounders. Of 201 propensity score-matched pairs, mean age was 63 ± 17 years, 51% were male, and 60% had an initial rhythm of pulseless electric activity. Survival to hospital discharge was greater in patients who received TH (17.6% versus 28.9%; P < 0.01), as was a discharge Cerebral Performance Category of 1 to 2 (13.7% versus 21.4%; P = 0.04). In adjusted analyses, patients who received TH were more likely to survive (odds ratio, 2.8; 95% confidence interval, 1.6-4.7) and to have better neurological outcome (odds ratio, 3.5; 95% confidence interval, 1.8-6.6) than those that did not receive TH.

conclusionsUsing propensity score matching, we found that patients with nonshockable initial rhythms treated with TH had better survival and neurological outcome at hospital discharge than those who did not receive TH. Our findings further support the use of TH in patients with initial nonshockable arrest rhythms.

Indexed as

AgedAged, 80 and overCardiopulmonary ResuscitationCohort StudiesFemaleHeart ArrestHumansHypothermia, InducedMaleMiddle AgedOut-of-Hospital Cardiac ArrestRetrospective StudiesSyndromeTreatment Outcomecardiopulmonary resuscitationheart arresthypothermia, inducedresuscitation

Identifiers

PMID26572795
PMCPMC4881859
OpenAlexW999291899

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.