Trial reportJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2016
Genetic Risk Scores Implicated in Adult Bone Fragility Associate With Pediatric Bone Density.
Trial report in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- A Meta-Analysis of the Transferability of Bone Mineral Density Genetic Loci Associations From European to African Ancestry Populations.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2021Pooled it
- The gSOS polygenic score is associated with bone density and fracture risk in childhood.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2025Article
- Prevalence and predictors of low bone mineral density in pediatric inflammatory bowel disease.Journal of pediatric gastroenterology and nutrition · 2025Article
- Enhanced fracture risk prediction: a novel multi-trait genetic approach integrating polygenic scores of fracture-related traits.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2024Article
- Assessment of the concentration of osteoprotegerin and receptor activator of nuclear factor kB ligand in healthy children.Pediatric endocrinology, diabetes, and metabolism · 2024Article
- The clinical utility of the BMD-related comprehensive genome-wide polygenic score in identifying individuals with a high risk of osteoporotic fractures.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2023Article
- Single-cell RNA sequencing revealsFrontiers in endocrinology · 2023Article
- Genetic Risk for Osteoporosis and the Benefit of Adherence to Healthy Lifestyles.International journal of public health · 2022Article
- The Polygenic and Monogenic Basis of Paediatric Fractures.Current osteoporosis reports · 2021Review
- Improved prediction of fracture risk leveraging a genome-wide polygenic risk score.Genome medicine · 2021Article
- Assessing the clinical utility of genetic profiling in fracture risk prediction: a decision curve analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2021Article
- Dual-energy X-ray absorptiometry bone densitometry in pediatrics: a practical review and update.Pediatric radiology · 2021Review
- Article
- Genetic profiling of decreased bone mineral density in an independent sample of Caucasian women.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018Article
- Physical Activity and Bone Accretion: Isotemporal Modeling and Genetic Interactions.Medicine and science in sports and exercise · 2018Article
- A Genomewide Association Study Identifies Two Sex-Specific Loci, at SPTB and IZUMO3, Influencing Pediatric Bone Mineral Density at Multiple Skeletal Sites.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2017Article
- Rare EN1 Variants and Pediatric Bone Mass.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2016Article
- Physical Activity Benefits the Skeleton of Children Genetically Predisposed to Lower Bone Density in Adulthood.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2016Article
- The case for genome-wide association studies of bone acquisition in paediatric and adolescent populations.BoneKEy reports · 2016Review
- Genetics of pediatric bone strength.BoneKEy reports · 2016Review
Corrections and comments
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Authors and funding
13 authors at 7 institutions in 2 countries.
Funding
Abstract
Using adult identified bone mineral density (BMD) loci, we calculated genetic risk scores (GRS) to determine if they were associated with changes in BMD during childhood. Longitudinal data from the Bone Mineral Density in Childhood Study were analyzed (N = 798, 54% female, all European ancestry). Participants had up to 6 annual dual energy X-ray scans, from which areal BMD (aBMD) Z-scores for the spine, total hip, and femoral neck were estimated, as well as total body less head bone mineral content (TBLH-BMC) Z-scores. Sixty-three single-nucleotide polymorphisms (SNPs) were genotyped, and the percentage of BMD-lowering alleles carried was calculated (overall adult GRS). Subtype GRS that include SNPs associated with fracture risk, pediatric BMD, WNT signaling, RANK-RANKL-OPG, and mesenchymal stem cell differentiation were also calculated. Linear mixed effects models were used to test associations between each GRS and bone Z-scores, and if any association differed by sex and/or chronological age. The overall adult, fracture, and WNT signaling GRS were associated with lower Z-scores (eg, spine aBMD Z-score: βadult = -0.04, p = 3.4 × 10(-7) ; βfracture = -0.02, p = 8.9 × 10(-6) ; βWNT = -0.01, p = 3.9 × 10(-4) ). The overall adult GRS was more strongly associated with lower Z-scores in females (p-interaction ≤ 0.05 for all sites). The fracture GRS was more strongly associated with lower Z-scores with increasing age (p-interaction ≤ 0.05 for all sites). The WNT GRS associations remained consistent for both sexes and all ages (p-interaction > 0.05 for all sites). The RANK-RANKL-OPG GRS was more strongly associated in females with increasing age (p-interaction < 0.05 for all sites). The mesenchymal stem cell GRS was associated with lower total hip and femoral neck Z-scores, in both boys and girls, across all ages. No associations were observed between the pediatric GRS and bone Z-scores. In conclusion, adult identified BMD loci associated with BMD and BMC in the pediatric setting, especially in females and in loci involved in fracture risk and WNT signaling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.