Evidence map›Paper›PMID 26572695›Full record

Trial reportClinical endocrinology2016

Subcutaneous infusion of kisspeptin-54 stimulates gonadotrophin release in women and the response correlates with basal oestradiol levels.

Shakunthala Narayanaswamy, Channa N Jayasena, Noel Ng, Risheka Ratnasabapathy, Julia K Prague, Deborah Papadopoulou, Ali Abbara, Alexander N Comninos, Paul Bassett, Stephen R Bloom and 2 more

Open access · hybridAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical endocrinology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
5.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 36 citations in OpenAlex.

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  15. Acute exposure to 4-OH-A, not PCBEnvironmental toxicology and pharmacology · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Shakunthala NarayanaswamySection of Investigative Medicine, Imperial College London, Hammersmith Hospital, London, UK.
Channa N JayasenaSection of Investigative Medicine, Imperial College London, Hammersmith Hospital, London, UK.
Noel NgSection of Investigative Medicine, Imperial College London, Hammersmith Hospital, London, UK.
Risheka RatnasabapathySection of Investigative Medicine, Imperial College London, Hammersmith Hospital, London, UK.
Julia K PragueSection of Investigative Medicine, Imperial College London, Hammersmith Hospital, London, UK.
Deborah PapadopoulouSection of Investigative Medicine, Imperial College London, Hammersmith Hospital, London, UK.
Ali AbbaraSection of Investigative Medicine, Imperial College London, Hammersmith Hospital, London, UK.
Alexander N ComninosSection of Investigative Medicine, Imperial College London, Hammersmith Hospital, London, UK.
Paul BassettStatsconsultancy Ltd, Bucks, UK.
Stephen R BloomSection of Investigative Medicine, Imperial College London, Hammersmith Hospital, London, UK.
Johannes D VeldhuisEndocrine Research Unit, Center for Translational Science Activities, Mayo Clinic, Rochester, Minnesota, USA.
Waljit S DhilloSection of Investigative Medicine, Imperial College London, Hammersmith Hospital, London, UK.
Hammersmith Hospital · GBImperial College London · GBMayo Clinic · US

Funding

Department of Health CDF-2009-02-05Department of Health RP-2014-05-001
6 · The paper itself

Abstract

BACKGROUND AND

objectiveKisspeptin stimulates hypothalamic GnRH secretion resulting in gonadotrophin release and has potential as a future therapeutic. Chronic subcutaneous infusion of kisspeptin via a pump (similar to an insulin pump) may provide an alternative route of administration in the future. We investigated for the first time in humans, the gonadotrophin response to subcutaneous (SC) infusions of kisspeptin-54 in healthy women. Women are markedly more responsive to exogenous kisspeptin in the late follicular phase preovulation when oestradiol levels are naturally high. Therefore, we further investigated whether there was a correlation between baseline oestradiol levels and LH response to kisspeptin. DESIGN AND PATIENTS: A prospective, single-blinded placebo-controlled study. Healthy women (n = 4) received an 8-h SC infusion of kisspeptin-54 0·1, 0·3 or 1·0 nmol/kg/h or saline in the early follicular phase of 4 separate menstrual cycles. Gonadotrophins and oestradiol were measured every 10 min during the infusions.

resultsSC infusion of kisspeptin-54 increased LH and FSH. The LH response to SC infusion of kisspeptin-54 (0·3 and 1·0 nmol/kg/h) positively correlated with baseline oestradiol levels (P < 0·001). Further statistical analyses showed that in the 1·0 nmol/kg/h group, a 100pmol/l rise in baseline oestradiol was associated with a 1·0 IU/l increase in LH.

conclusionsKisspeptin administered via a SC infusion could be a viable future therapeutic route of administration for patients with infertility. Baseline oestradiol levels may be an important determinant of the gonadotrophin response to kisspeptin treatment in women and should be taken into consideration when evaluating gonadotrophin response.

Indexed as

AdolescentAdultEstradiolFemaleFollicular PhaseGonadotropin-Releasing HormoneGonadotropinsHumansInfusions, SubcutaneousKisspeptinsLuteinizing HormoneProspective StudiesYoung AdultEstradiolGonadotropin-Releasing HormoneGonadotropinsKISS1 protein, humanKisspeptinsLuteinizing Hormone

Identifiers

PMID26572695
PMCPMC4914955
OpenAlexW2178428451

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.