Evidence map›Paper›PMID 26572620›Full record

ArticleThe Journal of cell biology2015

The interactome challenge.

John D Aitchison, Michael P Rout

Abstract read
In one paragraph

Article in The Journal of cell biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Methods for mapping 3D chromosome architecture.Nature reviews. Genetics · 2020
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Protein Complex Affinity Capture from Cryomilled Mammalian Cells.Journal of visualized experiments : JoVE · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

John D AitchisonCenter for Infectious Disease Research (formerly Seattle Biomedical Research Institute), Seattle, WA 98109 Institute for Systems Biology, Seattle, WA 98109 rout@rockefeller.edu john.aitchison@cidresearch.org.
Michael P RoutLaboratory of Cellular and Structural Biology, The Rockefeller University, New York, NY 10065 rout@rockefeller.edu john.aitchison@cidresearch.org.

Funding

Quantitative Systems BiologyP50GM076547 · NIGMS · INSTITUTE FOR SYSTEMS BIOLOGY · PI DUDLEY, AIMEE M · 2006 to 2016
$30.6M
TR&D Project 4. The Imaging Stage: Multiscale Spatiotemporal Modeling of Macromolecular Systems in Cellular NeighborhoodsP41GM109824 · NIGMS · ROCKEFELLER UNIVERSITY · PI ROUT, MICHAEL P · 2014 to 2023
$18.8M
Structure-Function Mapping of the Nuclear Pore Complex-RenewalR01GM112108 · NIGMS · ROCKEFELLER UNIVERSITY · PI JOHN D. AITCHISON, MICHAEL P ROUT · 2015 to 2026
$9.1M
NIGMS NIH HHS P41 GM109824NIGMS NIH HHS P50 GM076547NIGMS NIH HHS R01 GM112108
6 · The paper itself

Abstract

The properties of living cells are mediated by a huge number of ever-changing interactions of their component macromolecules forming living machines; collectively, these are termed the interactome. Pathogenic alterations in interactomes mechanistically underlie diseases. Therefore, there exists an essential need for much better tools to reveal and dissect interactomes. This need is only now beginning to be met.

Indexed as

Protein Interaction MapsHumansProtein Interaction MappingSystems Analysis

Identifiers

PMID26572620
PMCPMC4657177

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.