Evidence map›Paper›PMID 26572609›Full record

Trial reportBMC geriatrics2015

Effects of protein-rich nutritional supplementation and bisphosphonates on body composition, handgrip strength and health-related quality of life after hip fracture: a 12-month randomized controlled study.

Lena Flodin, Tommy Cederholm, Maria Sääf, Eva Samnegård, Wilhelmina Ekström, Amer N Al-Ani, Margareta Hedström

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC geriatrics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01950169 (Effects of Bisphosphonates and Nutritional Supplementation After a Hip Fracture), which is not on this map. Cited by 26 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 7 pooled it
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01950169 nacompletednot on this map

Effects of Bisphosphonates and Nutritional Supplementation After a Hip Fracture

TypeinterventionalSponsorKarolinska InstitutetRan2004 to 2009Enrolled79ConditionsHip FractureArmsRisedronate, Nutritional supplement, Calcium and vitamin D3
3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 7 syntheses or guidelines pooled it, 47 citations in OpenAlex.

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  20. The global approach to rehabilitation following an osteoporotic fragility fracture: A review of the rehabilitation working group of the International Osteoporosis Foundation (IOF) committee of scientific advisors.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Lena FlodinDepartment of Geriatric Medicine, Karolinska University Hospital, Stockholm, Sweden. lena.flodin@karolinska.se.
Tommy CederholmDepartment of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, Uppsala, Sweden. tommy.cederholm@pubcare.uu.se.
Maria SääfDepartment of Endocrinology, Metabolism and Diabetes, Karolinska University Hospital, Stockholm, Sweden. maria.saaf@karolinska.se.
Eva SamnegårdDivision of Orthopedics, Department of Clinical Science, Karolinska Institutet, Danderyd Hospital, Stockholm, Sweden. eva.samnegard@ki.se.
Wilhelmina EkströmKarolinska Institutet, Department of Molecular Medicine and Surgery, Section of Orthopedics and Sports Medicine, Karolinska University Hospital, Stockholm, Sweden. wilhelmina.ekstrom@karolinska.se.
Amer N Al-AniDepartment of Orthopedics, Karolinska University Hospital, Stockholm, Sweden. amer.al-ani@ptj.se.
Margareta HedströmDepartment of Orthopedics, Karolinska University Hospital, Stockholm, Sweden. margareta.hedstrom@karolinska.se.
Karolinska University Hospital · SEKarolinska Institutet · SEUppsala University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe catabolic state that follows hip fracture contributes to loss of muscle mass and strength, that is sarcopenia, which impacts functional ability and health-related quality of life. Measures to prevent such long-term postoperative consequences are of important concern. The aim of this study was to evaluate the combined effects of protein-rich nutritional supplementation and bisphosphonate on body composition, handgrip strength and health-related quality of life following hip fracture.

methodsThe study included 79 men and women with hip fracture, mean age 79 years (SD 9), without severe cognitive impairment, who were ambulatory and living independently before fracture. Patients were randomized postoperatively to receive liquid supplementation that provided 40 g of protein and 600 kcal daily for six months after the fracture, in addition to bisphosphonates once weekly for 12 months (group N, n = 26), or bisphosphonates alone once weekly for 12 months (group B, n = 28). All patients, including the controls (group C, n = 25) received calcium 1 g and vitamin D3 800 IU daily. Body composition as measured by dual-energy X-ray absorptiometry (DXA), handgrip strength (HGS) and health-related quality of life (HRQoL) were registered at baseline, six and 12 months postoperatively.

resultsThere were no differences among the groups regarding change in fat-free mass index (FFMI), HGS, or HRQoL during the study year. Intra-group analyses showed improvement of HGS between baseline and six months in the N group (P = 0.04). HRQoL decreased during the first year in the C and B groups (P = 0.03 and P = 0.01, respectively) but not in the nutritional supplementation N group (P = 0.22).

conclusionsProtein-rich nutritional supplementation was unable to preserve FFMI more effectively than vitamin D and calcium alone, or combined with bisphosphonate, in this relatively healthy group of hip fracture patients. However, trends toward positive effects on both HGS and HRQoL were observed following nutritional supplementation.

trial registrationClinicaltrials.gov NCT01950169 (Date of registration 23 Sept 2013).

Indexed as

Fracture FixationHip FracturesPostoperative ComplicationsQuality of LifeSarcopeniaAbsorptiometry, PhotonActivities of Daily LivingAgedBody CompositionBone Density Conservation AgentsDietary ProteinsDietary SupplementsDiphosphonatesFemaleHand StrengthHumansBone Density Conservation AgentsDietary ProteinsDiphosphonatesVitamin D

Identifiers

PMID26572609
PMCPMC4647612
OpenAlexW2177553561

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.