ArticleSpinal cord2016
Circadian variations in melatonin and cortisol in patients with cervical spinal cord injury.
Article in Spinal cord, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Endocrinological and inflammatory markers in individuals with spinal cord injury: A systematic review and meta-analysis.Reviews in endocrine & metabolic disorders · 2022Pooled it
- A review of sleep research in patients with spinal cord injury.The journal of spinal cord medicine · 2020Pooled it
- Systematic review of melatonin levels in individuals with complete cervical spinal cord injury.The journal of spinal cord medicine · 2020Pooled it
- Psychological Distress and Biological Stress Markers After Spinal Cord Injury: A Longitudinal Multi-Omics Pilot Study.International journal of molecular sciences · 2026Article
- SGK1 upregulation in GFAPCell death & disease · 2025Article
- The correlation of sleep disorders with postoperative outcomes in spine surgery: A narrative review.North American Spine Society journal · 2025Article
- Post-mastectomy pain syndrome and sleep disorders: effects of physical activity.Frontiers in sports and active living · 2025Article
- A glucocorticoid spike derails muscle repair to heterotopic ossification after spinal cord injury.Cell reports. Medicine · 2024Article
- Article
- Observational
- Effects of exercise timing and intensity on physiological circadian rhythm and sleep quality: a systematic review.Physical activity and nutrition · 2023Article
- A comprehensive look at the psychoneuroimmunoendocrinology of spinal cord injury and its progression: mechanisms and clinical opportunities.Military Medical Research · 2023Review
- Melatonin-mediated FKBP4 downregulation protects against stress-induced neuronal mitochondria dysfunctions by blocking nuclear translocation of GR.Cell death & disease · 2023Article
- Consequences of spinal cord injury on the sympathetic nervous system.Frontiers in cellular neuroscience · 2023Review
- Are Morphometric and Biomechanical Characteristics of Lumbar Multifidus Related to Pain Intensity or Disability in People With Chronic Low Back Pain After Considering Psychological Factors or Insomnia?Frontiers in psychiatry · 2022Article
- Circadian rhythms and pain.Neuroscience and biobehavioral reviews · 2021Review
- Salivary melatonin in oral squamous cell carcinoma patients.Scientific reports · 2021Article
- The effects of a high-fat/high-carbohydrate meal on leukocyte populations in adults with chronic spinal cord injury.Spinal cord series and cases · 2021Article
- Implications of Disrupted Circadian Rhythms on Pain.Journal of psychiatry and brain science · 2021Article
- Melatonin inhibits attention-deficit/hyperactivity disorder caused by atopic dermatitis-induced psychological stress in an NC/Nga atopic-like mouse model.Scientific reports · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeIn cervical spinal cord injury (CSCI), afferent and efferent circuits that influence the basal production of melatonin and cortisol may be disrupted and hence disrupt the basal functions of human physiology. Therefore, the aim of this study was to assess circadian changes, if any, in serum cortisol and melatonin in patients with CSCI.
methodsSerum levels of cortisol and melatonin were measured at 6-h intervals of the day (0600, 1200, 1800 and 0000 hours) in 22 CSCI patients, as well as 22 healthy controls.
resultsSignificantly higher melatonin levels were observed in the patient group in morning hours, whereas a significantly lower level of melatonin was found during the night time in the patient group than in the control group. Moreover, significantly higher values were obtained in the evening and night time serum cortisol levels among the patients compared with controls. Further, when the mean values of cortisol throughout the day were tested among patient and control groups similar circadian rhythm was found. The only difference being that serum cortisol declined much more in controls in evening and night samples as compared with CSCI patients.
conclusionWe conclude that circadian variations exist in the circulating levels of serum cortisol and melatonin in patients with CSCI. Low levels of melatonin secretion during night may contribute to the pervasive sleep disruption and increased pain perception.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.