Evidence map›Paper›PMID 26572496›Full record

Trial reportJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2016

Relationship of Height to Site-Specific Fracture Risk in Postmenopausal Women.

Miranda Eg Armstrong, Oksana Kirichek, Benjamin J Cairns, Jane Green, Gillian K Reeves, Valerie Beral for the Million Women Study Collaborators

Abstract readClinical TrialMulticenter Study
In one paragraph

Trial report in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Article
  2. Birth weight and birth length affect future fracture risk differently in men and women.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2024
    Article
  3. Article
  4. Article
  5. Osteosarcopenia: Adjust for the BMI or Bare the Bias.Calcified tissue international · 2024
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Height loss in postmenopausal women-do we need more for fracture risk assessment? Results from the GO Study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2021
    Article
  17. Article
  18. Measured height loss predicts incident clinical fractures independently from FRAX: a registry-based cohort study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2020
    Article
  19. Article
  20. Scaling of adult human bone and skeletal muscle mass to height in the US population.American journal of human biology : the official journal of the Human Biology Council · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Miranda Eg ArmstrongCancer Epidemiology Unit, University of Oxford, Oxford, UK.
Oksana KirichekCancer Epidemiology Unit, University of Oxford, Oxford, UK.
Benjamin J CairnsCancer Epidemiology Unit, University of Oxford, Oxford, UK.
Jane GreenCancer Epidemiology Unit, University of Oxford, Oxford, UK.
Gillian K ReevesCancer Epidemiology Unit, University of Oxford, Oxford, UK.
Valerie Beral for the Million Women Study Collaborators

Funding

Cancer Research UK 16491Cancer Research UK C570/A11692Medical Research Council MR/K02700X/1
6 · The paper itself

Abstract

Height has been associated with increased risk of fracture of the neck of femur. However, information on the association of height with fractures at other sites is limited and conflicting. A total of 796,081 postmenopausal women, who reported on health and lifestyle factors including a history of previous fractures and osteoporosis, were followed for 8 years for incident fracture at various sites by record linkage to National Health Service hospital admission data. Adjusted relative risks of fracture at different sites per 10-cm increase in height were estimated using Cox regression. Numbers with site-specific fractures were: humerus (3036 cases), radius and/or ulna (1775), wrist (9684), neck of femur (5734), femur (not neck) (713), patella (649), tibia and/or fibula (1811), ankle (5523), and clavicle/spine/rib (2174). The risk of fracture of the neck of femur increased with increasing height (relative risk [RR] = 1.48 per 10-cm increase, 99% confidence interval [CI] 1.39-1.57) and the proportional increase in risk was significantly greater than for all other fracture sites (pheterogeneity < 0.001). For the other sites, fracture risk also increased with height (RR = 1.15 per 10 cm, CI 1.12-1.18), but there was only very weak evidence of a possible difference in risk between the sites (pheterogeneity = 0.03). In conclusion, taller women are at increased risk of fracture, especially of the neck of femur.

Indexed as

Body HeightPostmenopauseAgedFemaleFractures, BoneHumansMiddle AgedRisk FactorsUnited KingdomFRACTUREHEIGHTMILLION WOMEN STUDYPOSTMENOPAUSALPROSPECTIVE STUDIES

Identifiers

PMID26572496
PMCPMC4832288

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.